46 publications found

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  • 2018
    Hjortness M.K. , Riccardi L.iit , Hongdusit A. , Ruppe A. , Zhao M. , Kim E.Y. , Zwart P.H. , Sankaran B. , Arthanari H. , Sousa M.C. , De Vivo M.iit , Fox J.M.

    Abietane-Type Diterpenoids Inhibit Protein Tyrosine Phosphatases by Stabilizing an Inactive Enzyme Conformation

    Biochemistry, vol. 57, (no. 40), pp. 5886-5896
    Article
  • 2018
    Genna V.iit , Carloni P. , *De Vivo M.iit

    A Strategically Located Arg/Lys Residue Promotes Correct Base Paring during Nucleic Acid Biosynthesis in Polymerases

    Journal of the American Chemical Society, vol. 140, (no. 9), pp. 3312-3321
    Article
  • 2018
    Hjortness M.K. , Riccardi L.iit , Hongdusit A. , Zwart P.H. , Sankaran B. , De Vivo M.iit , Fox J.M.

    Evolutionarily Conserved Allosteric Communication in Protein Tyrosine Phosphatases

    Biochemistry, vol. 57, (no. 45), pp. 6443-6451
    Article
  • 2018
    Riccardi L.iit , Genna V.iit , *De Vivo M.iit

    Metal–ligand interactions in drug design

    Nature Reviews Chemistry, vol. 2, (no. 7), pp. 100-112
    Article
  • 2018
    Franco-Ulloa S.iit , La Sala G.iit , Miscione G.P. , *De Vivo M.iit

    Novel bacterial topoisomerase inhibitors exploit Asp83 and the intrinsic flexibility of the DNA gyrase binding site

    International Journal of Molecular Sciences, vol. 19, (no. 2)
    Article
  • 2018
    Ortega J.A.iit , Riccardi L.iit , Minniti E.iit , Borgogno M.iit , Arencibia J.M.iit , Greco M.L. , Minarini A. , Sissi C. , *De Vivo M.iit

    Pharmacophore Hybridization to Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity

    Journal of Medicinal Chemistry, vol. 61, (no. 3), pp. 1375-1379
    Article
  • 2018
    Oviatt A.A. , Kuriappan J.A.iit , Minniti E.iit , Vann K.R. , Onuorah P. , Minarini A. , *De Vivo M.iit , Osheroff N.

    Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ

    Bioorganic and Medicinal Chemistry Letters, vol. 28, (no. 17), pp. 2961-2968
    Article
  • 2018
    Genna V.iit , Colombo M. , *De Vivo M.iit , Marcia M.

    Second-Shell Basic Residues Expand the Two-Metal-Ion Architecture of DNA and RNA Processing Enzymes

    Structure, vol. 26, (no. 1), pp. 40-50.e2
    Article
  • 2018
    Genna V.iit , Donati E.iit , *De Vivo M.iit

    The Catalytic Mechanism of DNA and RNA Polymerases

    ACS Catalysis, vol. 8, (no. 12), pp. 11103-11118
    Article
  • 2017
    La Sala G.iit , Decherchi S.iit , *De Vivo M.iit , *Rocchia W.iit

    Allosteric Communication Networks in Proteins Revealed through Pocket Crosstalk Analysis

    ACS Central Science, vol. 3, (no. 9), pp. 949-960
    Article
  • 2017
    Dreyer J. , Brancato G. , Ippoliti E. , Genna V.iit , De Vivo M.iit , Carloni P. , Rothlisberger U.

    Chapter 9: First Principles Methods in Biology: From Continuum Models to Hybrid Ab initio Quantum Mechanics/Molecular Mechanics

    RSC Theoretical and Computational Chemistry Series, vol. 2017-January, (no. 9), pp. 294-339
    Book Chapter
  • 2017
    *Riccardi L.iit , Arencibia J.M.iit , Bono L.iit , *Armirotti A.iit , *Girotto S.iit , *De Vivo M.iit

    Lid domain plasticity and lipid flexibility modulate enzyme specificity in human monoacylglycerol lipase

    Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1862, (no. 5), pp. 441-451
    Article
  • 2017
    *De Vivo M.iit , Masetti M. , Rossetti G.

    Molecular modelling and simulations applied to challenging drug discovery targets

    Computational Tools for Chemical Biology, Publisher: Royal Society of Chemistry
    Book Chapter
  • 2017
    Riccardi L.iit , Gabrielli L. , Sun X. , De Biasi F. , Rastrelli F. , Mancin F. , *De Vivo M.iit

    Nanoparticle-Based Receptors Mimic Protein-Ligand Recognition

    Chem, vol. 3, (no. 1), pp. 92-109
    Article
  • 2017
    Minniti E.iit , Byl J.A.W. , Riccardi L.iit , Sissi C. , Rosini M. , De Vivo M.iit , Minarini A. , Osheroff N.

    Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα

    Bioorganic and Medicinal Chemistry Letters, vol. 27, (no. 20), pp. 4687-4693
    Article
  • 2017
    Ortega J.A.iit , Arencibia J.M.iit , La Sala G.iit , Borgogno M.iit , Bauer I.iit , Bono L.iit , Braccia C.iit , Armirotti A.iit , Girotto S.iit , Ganesan A. , *De Vivo M.iit

    Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells

    Journal of Medicinal Chemistry, vol. 60, (no. 13), pp. 5800-5815
    Article
  • 2017
    *De Vivo M.iit , *Cavalli A.iit

    Recent advances in dynamic docking for drug discovery

    Wiley Interdisciplinary Reviews: Computational Molecular Science, vol. 7, (no. 6)
    Article
  • 2016
    Genna V.iit , Vidossich P. , Ippoliti E. , *Carloni P. , De Vivo M.iit

    A Self-Activated Mechanism for Nucleic Acid Polymerization Catalyzed by DNA/RNA Polymerases

    Journal of the American Chemical Society, vol. 138, (no. 44), pp. 14592-14598
    Article
  • 2016
    Pavlin M. , Rossetti G. , De Vivo M.iit , Carloni P.

    Carnosine and Homocarnosine Degradation Mechanisms by the Human Carnosinase Enzyme CN1: Insights from Multiscale Simulations

    Biochemistry, vol. 55, (no. 19), pp. 2772-2784
    Article
  • 2016
    Genna V.iit , Gaspari R.iit , Dal Peraro M. , *De Vivo M.iit

    Cooperative motion of a key positively charged residue and metal ions for DNA replication catalyzed by human DNA Polymerase-η

    Nucleic Acids Research, vol. 44, (no. 6), pp. 2827-2836
    Article

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.