183 publications found

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  • 2017
    *Rampa A. , Montanari S. , Pruccoli L. , Bartolini M. , Falchi F.iit , Feoli A. , Cavalli A.iit , Belluti F. , Gobbi S. , Tarozzi A. , Bisi A.

    Chalcone-based carbamates for Alzheimer's disease treatment

    Future Medicinal Chemistry, vol. 9, (no. 8), pp. 749-764
    Article
  • 2017
    Schiebel J.iit , Gaspari R.iit , Sandner A. , Ngo K. , Gerber H.-D. , Cavalli A.iit , Ostermann A. , Heine A. , *Klebe G.

    Charges Shift Protonation: Neutron Diffraction Reveals that Aniline and 2-Aminopyridine Become Protonated Upon Binding to Trypsin

    Angewandte Chemie - International Edition, vol. 56, (no. 17), pp. 4887-4890
    Article
  • 2017
    Savarese M.iit , Raucci U. , Fukuda R. , Adamo C. , *Ehara M. , *Rega N.iit , *Ciofini I.

    Comparing the performance of TD-DFT and SAC-CI methods in the description of excited states potential energy surfaces: An excited state proton transfer reaction as case study

    Journal of Computational Chemistry, vol. 38, (no. 14), pp. 1084-1092
    Article
  • 2017
    *Bisi A. , *Cappadone C. , Rampa A. , Farruggia G. , Sargenti A. , Belluti F. , Di Martino R.M.C.iit , Malucelli E. , Meluzzi A. , Iotti S. , Gobbi S.

    Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity

    European Journal of Medicinal Chemistry, vol. 127, pp. 577-585
    Article
  • 2017
    Uliassi E. , Fiorani G. , Krauth-Siegel R.L. , Bergamini C. , Fato R. , Bianchini G. , Carlos Menendez J. , Molina M.T. , Lopez-Montero E. , Falchi F.iit , Cavalli A.iit , Gul S. , Kuzikov M. , Ellinger B. , Witt G. , Moraes C.B. , Freitas-Junior L.H. , Borsari C. , Costi M.P. , *Bolognesi M.L.

    Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity

    European Journal of Medicinal Chemistry, vol. 141, pp. 138-148
    Article
  • 2017
    De Simone A.iit , Russo D.iit , Ruda G.F.iit , Micoli A.iit , Ferraro M.iit , Di Martino R.M.C.iit , Ottonello G.iit , *Summa M.iit , Armirotti A.iit , Bandiera T.iit , Cavalli A.iit , *Bottegoni G.iit

    Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase

    Journal of Medicinal Chemistry, vol. 60, (no. 6), pp. 2287-2304
    Article
  • 2017
    *Sancho-Garcia J.C. , Perez-Jimenez A.J. , Savarese M.iit , Bremond E.iit , Adamo C.iit

    Determining the role of the underlying orbital-dependence of PBE0-DH and PBE-QIDH double-hybrid density functionals

    Journal of Computational Chemistry, vol. 38, (no. 17), pp. 1509-1514
    Article
  • 2017
    *Masetti M. , *Musiani F. , Bernetti M.iit , Falchi F.iit , Cavalli A.iit , Ciurli S. , Recanatini M.

    Development of a multisite model for Ni(II) ion in solution from thermodynamic and kinetic data

    Journal of Computational Chemistry, vol. 38, (no. 21), pp. 1834-1843
    Article
  • 2017
    Tassini S. , Sun L. , Lanko K. , Crespan E. , Langron E. , Falchi F.iit , Kissova M. , Armijos-Rivera J.I. , Delang L. , Mirabelli C. , *Neyts J. , Pieroni M. , Cavalli A.iit , Costantino G. , Maga G. , Vergani P. , Leyssen P. , *Radi M.

    Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases

    Journal of Medicinal Chemistry, vol. 60, (no. 4), pp. 1400-1416
    Article
  • 2017
    Plotegher N. , Berti G. , Ferrari E. , Tessari I. , Zanetti M. , Lunelli L. , Greggio E. , Bisaglia M. , Veronesi M.iit , Girotto S.iit , Dalla Serra M. , Perego C. , Casella L. , *Bubacco L.

    DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function

    Scientific Reports, vol. 7
    Article
  • 2017
    *Gioia D. , *Bertazzo M.iit , *Recanatini M. , *Masetti M. , *Cavalli A.iit

    Dynamic docking: A paradigm shift in computational drug discovery

    Molecules, vol. 22, (no. 11)
    Article
  • 2017
    *Riccardi L.iit , *Arencibia J.M.iit , *Bono L.iit , *Armirotti A.iit , *Girotto S.iit , *De Vivo M.iit

    Lid domain plasticity and lipid flexibility modulate enzyme specificity in human monoacylglycerol lipase

    Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1862, (no. 5), pp. 441-451
    Article
  • 2017
    Bruno S. , Uliassi E. , Zaffagnini M. , Prati F. , Bergamini C. , Amorati R. , Paredi G. , Margiotta M. , Conti P. , Costi M.P. , Kaiser M. , Cavalli A.iit , Fato R. , *Bolognesi M.L.

    Molecular basis for covalent inhibition of glyceraldehyde-3-phosphate dehydrogenase by a 2-phenoxy-1,4-naphthoquinone small molecule

    Chemical Biology and Drug Design, vol. 90, (no. 2), pp. 225-235
    Article
  • 2017
    *Simoni E. , Bartolini M. , Abu I.F. , Blockley A. , Gotti C. , Bottegoni G.iit , Caporaso R. , Bergamini C. , Andrisano V. , Cavalli A.iit , Mellor I.R. , Minarini A. , *Rosini M.

    Multitarget drug design strategy in Alzheimer's disease: Focus on cholinergic transmission and amyloid-β aggregation

    Future Medicinal Chemistry, vol. 9, (no. 10), pp. 953-963
    Review
  • 2017
    *Sancho-Garcia J.C. , Bremond E.iit , Savarese M.iit , Perez-Jimenez A.J. , Adamo C.iit

    Partnering dispersion corrections with modern parameter-free double-hybrid density functionals

    Physical Chemistry Chemical Physics, vol. 19, (no. 21), pp. 13481-13487
    Article
  • 2017
    Ortega J.A.iit , Arencibia J.M.iit , La Sala G.iit , Borgogno M.iit , Bauer I.iit , Bono L.iit , Braccia C.iit , Armirotti A.iit , Girotto S.iit , Ganesan A. , *De Vivo M.iit

    Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells

    Journal of Medicinal Chemistry, vol. 60, (no. 13), pp. 5800-5815
    Article
  • 2017
    Bernetti M.iit , Cavalli A.iit , *Mollica L.iit

    Protein-ligand (un)binding kinetics as a new paradigm for drug discovery at the crossroad between experiments and modelling

    MedChemComm, vol. 8, (no. 3), pp. 534-550
    Review
  • 2017
    Musiani F. , Gioia D. , Masetti M. , Falchi F.iit , Cavalli A.iit , Recanatini M. , *Ciurli S.

    Protein Tunnels: The Case of Urease Accessory Proteins

    Journal of Chemical Theory and Computation, vol. 13, (no. 5), pp. 2322-2331
    Article
  • 2017
    *De Vivo M.iit , *Cavalli A.iit

    Recent advances in dynamic docking for drug discovery

    Wiley Interdisciplinary Reviews: Computational Molecular Science, vol. 7, (no. 6)
    Article
  • 2017
    Di Martino R.M.C.iit , Luppi B. , Bisi A. , Gobbi S. , Rampa A. , Abruzzo A. , *Belluti F.

    Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin

    Expert Opinion on Therapeutic Patents, vol. 27, (no. 5), pp. 579-590
    Review

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.