H2020 ERC - Proof of Concept Grant 2020-2021
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HyperCube: Gram scale production of ferrite nanocubes and thermo-responsive polymer coated nanocubes for medical applications and further exploitation in other hyperthermia fields
Abstract: This project aims at the scale up production, characterization, future commercialization and clinical translation of magnetic iron oxides nanocubes of high magnetic and structural quality and the design and production of an in-flow set up for the further functionalization of the nanocubes with a thermo-responsive (TR) polymer shell. The nanocubes and TR-nanocubes are aimed to be used primarily as heat mediators in magnetic hyperthermia (MH) and as heatmediated drug agents for the delivery of chemotherapeutic drugs in a heat triggered-mediated chemotherapy for the treatment of tumors. Their use as contrast agents in magnetic resonance imaging (MRI) and magnetic particle imaging (MPI) stands as secondary applications and it will also be relevant in this project. Indeed, given the control over the materials, the scale up synthesis of nanocubes and the in-flow production of TR-nanocubes, we will deliver an unprecedented benchmark scaled product of nanocubes with optimal magneto-heat properties that shall ensure the transition of such materials towards the market and the clinics. In comparison to the standardly used and commercially available magnetic nanoparticles, the high magneto-heat performances at clinically safe magnetic radiofrequency, of such nanocubes will impact the treatment of tumor by MH, by multiple aspects: i) requiring less dose of magnetic materials to be injected intratumorally; ii) unique actuation of dual combination therapy of MH and local heattriggered drug release, which also will favor a more efficacious therapy at reduced dose of magnetic materials; iii) further degradation and clearance of the heat-mediator nanocubes thus enabling the further investigation of tumour progression by MRI, overcoming the current limitation of iron oxide nanoparticles now employed in MH for the treatment of Glioblastoma Multiforme. Instead, their magnetic response at frequency range of 20-40 kHz will make them appealing as contrast agents in MPI.
Total budget: 150000.0€
Total contribution: 150000.0€
H2020 ERC - Starting Grant 2016-2020
Colloidal Inorganic Nanostructures for Radiotherapy and Chemotherapy
Abstract: The goal of ICARO is to develop a nanocrystal (NC) platform to merge radio and chemotherapy into a single entity that acts more specific towards tumor cells. Our goal is to establish protocols for the preparation of radiolabelled-NCs that will be easily translated to the medical practice for radiotherapy. In particular, our objective is to develop heterostructures that will combine radio and chemotherapy, the latter of which is based on the use of magnetic nanoparticles that can trigger drug release under exposure to an alternating magnetic field (AMF). The radiotherapy will be based on the insertion of radionuclides on semiconductor nanocrystals. During this first part of the project, we have started to develop magnetic nanoparticles and heterostructures that have optimized heat performances under AMF. This is crucial in order to reduce the dose of magnetic material and to exploit the heat to efficiently activate the release of drug molecules that are associated to the particles.
Total budget: 1033609.88€
Total contribution: 1033609.88€