The Systems and Synthetic Biology research line couples the astoundingly wide diversity of biological systems with synthetic biology innovation in order to foster resource-efficient, low-carbon and economically viable bioprocess solutions. Systems and synthetic biology approaches can bend the huge biotransformation potential of natural systems to address the global challenges posed by environment, society and economics sustainability by repurposing the native cellular machinery for the production of desired fuels, chemicals and materials. Established on such principles, our group’s initiatives aim at accelerating bacterial cell factory development and at stabilizing the favourable phenotypes towards the target production. We are interested in developing biomolecular genetic and metabolic engineering tools along with modular and predictable control of cellular processes to help solve bottlenecks in the design, analysis, robustness, and scalability of cell factories through their efficient integration in bioreactors. Initially, our work is focused on developing proof-of-concept for product-oriented approaches. However, our biotechnological solutions will gradually be deployed towards the development of commercially relevant cell factories.
The design laboratory integrates physiological and systems-level data with computational models of the host organisms to predict manipulations that are likely to increase product titer, yield and productivity. The synthetic biology laboratory constructs bacterial workhorses with enhanced characteristics to boost the usage of bacterial cells as production platforms. The screening and fermentation laboratory performs fermentation and physiological characterization of bacterial cell factories in the laboratory scale applying both batch or fed-batch conditions. The analytics laboratory develops assays that balance precision and accuracy with throughput to accelerate the optimization of bacterial cell factories.
Established international collaborations mainly involve the European participants to our projects funded within the H2020 programme. Furthermore, our group can rely on a solid local collaborative network involving both academic subjects such as Politecnico di Torino and Università degli Studi di Torino and small and medium-sized enterprises striving towards innovative solutions.
- H2020-BIOTECH-05-2017 ENGICOIN "Engineered microbial factories for CO2 exploitation in an integrated waste treatment platform " funded by the Research and Innovation Action (RIA) financing mechanism. Date from: 01/01/2018. Date to: 31/12/2021.
- H2020-ISIB-2015-2 CELBICON “Cost-effective CO2 conversion into chemicals via combination of Capture, ELectrochemical and BI-ochemical CONversion technologies” funded by the Research and Innovation Action (RIA) financing mechanism. Date from: 2016-03-01. Date to: 2019-08-31.
- “CO2 Circle Lab (Acronym CCL)” funded by the Piemonte region relative to the thematic objective I - Research, technological development and innovation, Action I.1.a.1.5 “Sostegno alle Infrastrutture di ricerca considerate critiche/cruciali per i sistemi regionali” within the P.O.R FESR 2014/20 with Grant Agreement 321-34. Date from: 12/04/2018. Date to: 11/04/2019.