The Nanoscopy program targets new high-resolution non-invasive diagnostics in humans. Some of the developments have been funded under the umbrella of European Community Projects :
The main goals linked with the EU projects Eurobioimaging, SMD, LANIR, RENVISION and the technical scientific collaborations with Nikon, Leica and Coherent focus mainly on:
- In-vivo imaging from micro- to nano- spatial resolution scale.
- Lab-on-a-chip developments for integration on diagnostic devices and virtual reality platforms.
- Optical nanoscopy modules competitive with current electron microscopes both in terms of spatial/temporal resolution and costs.
- Correlative nanoscopy including optical super resolution in the far/near field, scanning probe microscopy, pump-probe spectroscopy and electron microscopy.
- Computational methods in optical microscopy and imaging
- The study and characterization of oncological and neurodegenerative diseases at cellular and molecular level (nuclear pore complex and membrane channels dynamics, chromatin-DNA organization and its dynamic changes as potential pre-neoplastic indicators, cellular molecular trafficking, protein accumulation pathways, miRNA traffic and dynamics, cell aggregation and growth),
- The study of tissue engineering processes (artificial retina, bone substitutes)
- The study of new materials (nanoparticle packing and functioning in nanocomposite materials).In the long term, a new paradigm for microscopy development can be envisaged, such as portable multimodal nanoscopes having the potential of being flexible, low power and tunable. Such a new generation of microscopes could integrate microscopy, spectroscopy and flow cytometry in the same instrument endowed of all the processing and visualization software on-board.The Nanoscopy research activities share with the Nikon Imaging Center a partner portfolio: Nikon, Coherent, JEOL, JPK, PicoQuant, Okolab, Physik Istrumente, Chroma, ISS, Hamamatsu. A long term partnership is also running with Abberior and Leica Microsystems companies.