My project is focused on understanding how the cellular and connectivity properties of neural assemblies shape the collective dynamics emerging at the network level. Together with the experimental team of T. Fellin (IIT Genova), we are particularly interested in the role of the various inhibitory subnetworks in shaping the dynamical patterns of spontaneous and sensory-evoked activity in mammalian neocortex. I investigate this question using numerical simulations of neural network dynamics and its associated mathematical reductions (relying on techniques coming from the field of statistical physics and dynamical systems theory). Back-and-forth between the multimodal recordings of the Fellin team and our reductionist theoretical approach, this joint effort aims at providing a comprehensive picture for the role of circuit features in shaping neocortical processing.
Modeling mesoscopic cortical dynamics using a mean-field model of conductance-based networks of adaptive exponential integrate-and-fire neurons. Zerlaut Y., Chemla S., Chavane F. and Destexhe A. Journal of Computational Neuroscience (2017). https://doi.org/10.1007/s10827-017-0668-2
Enhanced Responsiveness and Low-Level Awareness in Stochastic Network States Zerlaut Y. and Destexhe A. Neuron (2017) http://dx.doi.org/10.1016/j.neuron.2017.04.001
Heterogeneous firing responses predict diverse couplings to presynaptic activity in mice layer V pyramidal neurons Zerlaut Y. and Destexhe A. PLoS Computational Biology (2017) https://doi.org/10.1371/journal.pcbi.1005452
Heterogeneous firing response of mice layer V pyramidal neurons in the fluctuation-driven regime. Zerlaut Y., Telenczuk B., Deleuze C., Bal T., Ouanounou G. and Destexhe A. The Journal of Physiology (2016) http://dx.doi.org/10.1113/JP272317
Gain Modulation of Synaptic Inputs by Network State in Auditory Cortex In Vivo Reig R., Zerlaut Y., Vergara R., Destexhe A. and Sanchez-Vives M.V. The Journal of Neuroscience (2015) https://doi.org/10.1523/JNEUROSCI.2004-14.2015
2015 : Fellowship ”Espoirs de la Recherche” from the Fondation pour la Recherche Médicale
2012 : PhD fellowship from the Initiative d’Excellence Paris-Saclay