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Placido Illiano

PhD/Fellow

Former colleague

Center

NSYN@Unige Genova

Contacts

About

Placido Illiano, M.Sc.

Ph.D. Student

Italian Institute of Technology

Department of Neuroscience and Brain Techonology

Via Morego 30 16163 Genova, Italy

PUBLICATIONS

The Electroretinogram as a Tool to Investigate Psychiatric Disorders: The Implication of Central Dopamine and Serotonin

Biological psychiatry, ISSN 0006-3223, 03/2014, Volume 75, Issue 6, p. 479

Joëlle Lavoie,1-4, Placido Illiano, 3, Tatyana D. Sotnikova, 3, Raul R. Gainetdinov, 3, Jean-Martin Beaulieu, 1-4 and Marc Hébert, 2-4

Prepuberal Stimulation of 5-HT7-R by LP-211 in a Rat Model of Hyper-Activity and Attention-Deficit: Permanent Effects on Attention, Brain Amino Acids and Synaptic Markers in the Fronto-Striatal Interface

Lucia A. Ruocco,1, Concetta Treno,1, Ugo A. Gironi Carnevale,1, Claudio Arra,2, Gianpiero Boatto,3, Maria Nieddu,3, Cristina Pagano,4, Placido Illiano,4, Fabiana Barbato,4, Angela Tino,4, Ezio Carboni,5, Giovanni Laviola,6, Enza Lacivita,7, Marcello Leopoldo,7, Walter Adriani,6, Adolfo G. Sadile1*

 

Prepuberal intranasal dopamine treatment in an animal model of ADHD ameliorates deficient spatial attention, working memory, amino acid transmitters and synaptic markers in prefrontal cortex, ventral and dorsal striatum 

Amino Acids, 04/2014, DOI 10.1007/s00726-014-1753-8

L. A. Ruocco C. Treno U. A. Gironi Carnevale C. Arra C. Mattern J. P. Huston M. A. de Souza Silva S. Nikolaus A. Scorziello
M. Nieddu G. Boatto P. Illiano C. Pagano A. Tino A. G. Sadile 

PUBLISHED ABSTRACTS

Dopamine Transporter Knockout Rats 

European Neuropsychopharmacology - Volume 24, Supplement 1, March 2014, Pages S6–S7

Placido Illiano, 1, Damiana Leo, 1, Ilya Sukhanov, 1, Liudmila Mus, 1, Stefano Espinoza, 1, Tatyana D. Sotnikova, 1 and Raul R. Gainetdinov, 1.

1. Neuroscience and Brain Technologies Department, Italian Institute of Technology, Genoa, Italy.

 

ACADEMIC FORMATION 

Doctoral program (January 2012 to present):

PhD Student in Neuroscience and Brain Technologies - domain: monoamines

"Dopamine Transporter Knock-in mice carrying loss-of-function mutation found in patients with Dopamine Transporter Deficiency Syndrome (DTDS)"

Supervisor: Raul R. Gainetdinov, M.D., Ph.D

Master Degree (2006-2011)

Università degli Studi di Napoli Federico II, School of Pharmacy Naples, Italy

Master Degree in Pharmaceutical Chemistry and Technology

Grade:110/110

Supervisor: Prof. Maria Grazia Rimoli, Angela Tino, Ph.D.

 

WORKING EXPERIENCE

Visiting Ph.D. Student (March - May 2012) 

Collaboration for Ph.D. project 

Jean-Martin Beaulieu, Ph.D., laboratory, 

Faculty of Medicine, Department of Psychiatry and Neuroscience, Quebèc City, Canada. 

Visiting Ph.D. Student (September - November 2012) 

Collaboration for Ph.D. project 

Jean-Martin Beaulieu, Ph.D., laboratory, 

Faculty of Medicine, Department of Psychiatry and Neuroscience, Quebèc City, Canada. 

Post-graduate trainee (September - December 2011)

Cibernetica Institute "E. Caianiello", Italian Council of Researches, Pozzuoli, Naples

Master thesis program (March 2010- May 2011)

"Protein expression levels in brain areas of an animal model of ADHD in basal condition and after pharmacological treatments"

Cibernetica Institute "E. Caianiello", Italian Council of Researches, Pozzuoli, Naples

 

Competences 

  • Molecular Biology
  • Western Blotting
  • Mouse Models
  • Gene Therapy
  • Mouse Handling
  • Mouse and rat behavior
  • Special behavioral tests (H-Maze)
  • HPLC
  • Biochemistry
  • Confocal Microscopy
  • Rat Handling
  • Cell Culture
  • Immunohistochemistry
  • Immunofluorescence
  • Fluorescence Microscopy
  • PCR

 

 

 

POSTER PRESENTATIONS 

  • Dopamine Transporter Knockout Rats 

Placido Illiano, 1, Damiana Leo, 1, Ilya Sukhanov, 1, Liudmila Mus, 1, Stefano Espinoza, 1, Tatyana D. Sotnikova, 1 and Raul R. Gainetdinov, 1.

ECNP workshop 2014, Nice, France

1. Neuroscience and Brain Technologies Department, Italian Institute of Technology, Genoa, Italy.

  • A translational Medicine study on Dopamine Transporter Deficiency Syndrome: development of humanized-mutated murine models

May 2013: Dopamine 2013 (Alghero, Italy)

October 2013: Italian Society for Neuroscience (Rome, Italy)

Placido Illiano, 1, Claude Lamarre, 2, Jean-Martin Beaulieu, 2, Manju A. Kurian and Raul R. Gainetdinov, 1.

 1. Neuroscience and Brain Technologies Department, Italian Institute of Technology, Genoa, Italy. 2. Faculty of Medicine, Departments of Psychiatry and Neuroscience, Université Laval, Québec QC, Canada 3. University College of London, Institute of Child Health, Neuroscience Unit, London, United Kingdom.

 

  • Generation of humanized Dopamine Transporter Knock-in mouse strains carrying loss-of-function mutation as a model of human Dopamine Transporter Deficiency Syndrome 

June 2012: 6th Meeting of young researcher in Physiology (Sestri Levante, Italy)

October 2012: 6ème Journée de la rèchèrche en neuroscience - Université Laval, Québec City, Québec, Canada

(english poster/french language oral presentation)

Placido Illiano, 1, Claude Lamarre, 2, Jean-Martin Beaulieu, 2, and Raul R. Gainetdinov, 1. 

1. Neuroscience and Brain Technologies Department, Italian Institute of Technology, Genoa, Italy. 2. Faculty of Medicine, Departments of Psychiatry and Neuroscience, Université Laval, Québec QC, Canada

 

  • Prepuberal subchronic intranasal dopamine differentially affects dopamine transporter and modifies L-Glutamate,L-Aspartate and L-Leucine content in the fronto-striatal interface of Naples High-Excitability rats 

Society for Neuroscience 2011

P. Illiano,1, C. Pagano,1, A. Tino,1, G. Boatto,2, M. Nieddu, 2, C. Arra,3, C. Mattern, 4, M. A. DE Souza Silva, 5, J. P. Houston, 5, C. Treno, 6, L. A. Ruocco, 6, and A.G. Sadile, 6.

 

1CNR - Inst. of Cybernetics, Pozzuoli, Italy; 2Dept. of Drug Sci., Fac. of Pharm., Sassari, Italy; 3Animal facility,I.N.T.G. Pascale, Naples, Italy; 4M & P Pharma AG, Stans, Switzerland; 5Ctr. for Behavioral Neurosci., Heinrich-Heine-University, Düsseldorf, Germany; 6Second Univ. Naples (SUN), Naples, Italy

 

  • High levels of Dopamine Transporter and NMDAR1 Receptor in prefrontal cortex of Naples High Excitability rats, an animal model for ADHD: effects of Intranasal Dopamine or MK-801

International Brain Research Organisation 2011

C. Pagano1 and P. Illiano1, A.Tino1, A. Ambrosone1, L.A. Ruocco2, C.Treno2, C.Mattern3, M.A. De Souza Silva4, J.P. Huston4 and A.G. Sadile2.

1-CNR - National Research Council of Italy, Istituto di Cibernetica, Pozzuoli, Italy, 2-Second University of Naples, Dept. Experimental Medicine, Napoli, Italy, 3-M&P Pharma AG, Stans, Switzerland, 4-Heinrich-Heine University Düsseldorf, Center for Behav. Neuroscience, Düsseldorf Germany.

SPOKEN LANGUAGES 

Native: Italian

English - proficient (certifications: TOEFL + GRE)

French - proficient

 

 

 

Selected Publications

 

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.