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Paolo Decuzzi Write a Message

Senior Researcher TT (TT2)
Senior Researcher

Contacts

Via Morego 30
+39 010 71781 941

About

Paolo Decuzzi is a senior researcher and director of the Laboratory of Nanotechnology for Precision Medicine at the Italian Institute of Technology in Genova – Italy. Decuzzi’s lab mission is to i. rationally design polymeric nanoconstructs for multi-modal imaging and combination therapy in cancer, cardiovascular and neurological diseases; ii. fabricate microfluidic chips for the rapid screening of novel molecular and nano-based therapeutic agents; iii. develop multi-scale, hierarchical computational models for predicting the transport and therapeutic efficacy of nanoconstructs; iv. organize dissemination activities at the interface between engineering and biomedical sciences; and v. promote the professional development of lab members in a highly multi-disciplinary environment.

Dr. Decuzzi earned his M.Sc. degree in Mechanical Engineering from the Politecnico di Bari (Italy) in 1997 and his Ph.D. degree in Mechanical Engineering from the University of Naples – Federico II (Italy) in 2000, with a thesis on friction and adhesion at the nanoscale. In 2002, he was nominated Assistant Professor of Machine Design at the Politecnico di Bari and, in 2005, he became Associate Professor in the School of Medicine of the University ‘Magna Graecia’. There, he cofounded BioNEM - the laboratory of BioNanotechnology and Engineering for Medicine - one of the first nanoengineering laboratories built in a School of Medicine. In October 2007, he joined The University of Texas Health Science Center in Houston as an Associate Professor of Biomedical Engineering. In October 2010, he moved to the Houston Methodist Hospital where he served as a Professor of Biomedical Engineering till July 2015. There, he founded the Center for the Rational Design of Multifunctional Nanoconstructs, with the financial support of the Cancer Prevention and Research Center of Texas and the US National Cancer Institute; and served first as the co-chair of the Nanomedicine Department and then as the interim chair of the Translational Imaging Department. In July 2014, Dr. Decuzzi was awarded a 5-year European Research Council “Consolidator Grant” to design, synthesize and develop nanoconstructs for imaging and therapy in brain cancer.

Dr. Decuzzi has been visiting scientist at the Department of Theoretical and Applied Mechanics at the University of Michigan - Ann Arbor (1998, 1999 and 2001); and visiting professor at the Princeton Material Institute – Princeton (2003); the Heart and Lung Institute at the Ohio State University  (2003 and 2004); the University of Texas Health Science Center (2006).

Dr. Decuzzi has published over 150 papers in international peer-reviewed journals, international conferences and book chapters. He holds over 5 patents in the field of Nanomedicine. He co-founded NEMB – NanoEngineering for Medicine and Biology – committee of the American Society for Mechanical Engineers and is involved in multiple dissemination activities to foster the collaboration between biomedical scientists and engineers. He serves on multiple NIH, NSF, ESF, and Italian Government study sections and his research activity is primarily supported by NIH, DOD, CPRIT in USA; ESF and ERC in EU.

Projects

Major Projects:

2014

P. Decuzzi(PI) Engineering Discoidal Polymeric Nanoconstructs for the Multi-Physics Treatment of Brain Tumors. European Research Council Consolidator Grant 07/01/2014 - 06/30/19 (Euro 2,400,000)

2012 P. Decuzzi(co-PI) Circulating tumor microemboli (CTM) interactions with blood cells and plasma in the vascular microenvironment. National Cancer Institute, Trans-network PS-OC project 06/01/2012-05/30/13 ($ 496,000)
2011 P. Decuzzi (PI) Rationally designed magnetic nanoconstructs for the imaging and hyperthermia of tumor cells and neovasculature. Cancer Prevention Research Institute of Texas 02/01/2011-01/31/2014 (ca $1,500,000)
2008 P. Decuzzi (co-PI and Project Leader) An Integrated Framework for Engineering Bio-Mimetic Adhesive Interface European Science Foundation EUROCORES Programme FANAS 09/01/2008 – 08/31/2011 (1,200,000 Euro)
2007 P. Decuzzi (co-PI) BioGEO-Understanding the Effect of Size and Shape in Biological Systems to Learn Fabricating Biomimetic Artifical Systems with Superior Properties US Department of Defense, 09/18/2007 – 04/17/2008 ($300,000)
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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

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IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.

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