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Giuliana Ottonello

Analytical Chemistry Facility
Technician
Analytical Chemistry
Phone
Research center
Biografia

I have a Master’s degree in Chemistry and a Ph.D. in Chemical Sciences and Technologies focused on the development of analytical GC-MS methods for identification of environmental pollutants in food. I deepened my knowledge in the analytical chemistry field working for five years at the Ligurian Chemical Laboratory of the  Experimental Zooprophylactic Institute of Piemonte, Liguria e Valle d’Aosta, where we analyzed food to detect environmental pollutants, heavy metals, histamine, marine biotoxins and additives thus assuring food safety. In  2012 I joined the Analytical Chemistry Lab at IIT and I started to approach the world of Drug Discovery, dealing with in vitro ADME studies. Today, I’m in charge of most of the DMPK screening assays that our Lab performs such as solubility, metabolic stability, plasma protein binding and permeability assays. Moreover, I normally take part in external projects that involve other IIT Centres, universities or companies. I am among the invertors of Italian patent 102021000018455 “Biomarcatori della Malattia di Alzheimer” and I’m a co-author in 23 papers (2 as First).

Education

Title: Master's degree in Chemistry
Institute: University of Genoa
Location: Genova
Country: Italy
From: 2003 To: null

Title: Ph. D. degree in Chemical Sciences and Technologies
Institute: University of Genoa
Location: Genova
Country: Italy
From: 2011 To: null

All Publications
2023
Munafo F., Nigro M., Brindani N., Manigrasso J., Geronimo I., Ottonello G., Armirotti A., De Vivo M.
Computer-aided identification, synthesis, and biological evaluation of DNA polymerase η inhibitors for the treatment of cancer
European Journal of Medicinal Chemistry, vol. 248
2023
Brindani N., Munafo F., Menichetti A., Donati E., Nigro M., Ottonello G., Armirotti A., De Vivo M.
Design, synthesis, docking, and biochemical characterization of non-nucleoside SARS-CoV-2 RdRp inhibitors
Bioorganic and Medicinal Chemistry, vol. 80
2022
Munafò F., Nigro M., Brindani N., Manigrasso J., Geronimo I., Ottonello G., Armirotti A., De Vivo M.
Computer-aided identification, synthesis, and biological evaluation of DNA polymerase η inhibitors for the treatment of cancer
European Journal of Medicinal Chemistry
Article Journal
2022
Munafo F., Donati E., Brindani N., Ottonello G., Armirotti A., De Vivo M.
Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase
Scientific Reports, vol. 12, (no. 1)
2021
Borgogno M., Savardi A., Manigrasso J., Turci A., Portioli C., Ottonello G., Bertozzi S.M., Armirotti A., Contestabile A., Cancedda L., De Vivo M.
Design, Synthesis,In VitroandIn VivoCharacterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in down Syndrome
Journal of Medicinal Chemistry, vol. 64, (no. 14), pp. 10203-10229
Article Journal