Publications
2023
Savardi A., Patricelli Malizia A., De Vivo M., Cancedda L., Borgogno M.
Preclinical Development of the Na-K-2Cl Co-transporter-1 (NKCC1) Inhibitor ARN23746 for the Treatment of Neurodevelopmental Disorders
ACS Pharmacology and Translational Science, vol. 6, (no. 1), pp. 1-11
Article
Journal
2022
Cwetsch A.W., Ziogas I., Narducci R., Savardi A., Bolla M., Pinto B., Perlini L.E., Bassani S., Passafaro M., Cancedda L.
A rat model of a focal mosaic expression of PCDH19 replicates human brain developmental abnormalities and behaviours
Brain Communications, vol. 4, (no. 3)
2022
Stuefer A., Balasco L., Bertozzi S., Coletta L., Hayward A., Rocchi F., Montani C., Alvino F., Galbusera A., Aldrighetti M., Gini S., Curcic V., Papaleo F., Iurilli G., Cancedda L., Armirotti A., Bozzi Y., Gozzi A.
Chemogenetic excitation of pyramidal neurons during early development: a longitudinal behavioral and imaging study
SfN
Poster
Conference
2022
Montani C., Hayward A., Gutierrez-Barragan D., Morelli G., Alvino F. G., Coletta L., Galbusera A., Pasqualetti M., Cancedda L., Gozzi A.
Chemogenetic stimulation of oxytocinergic neurons dynamically modulates fMRI connectivity
Annual Meeting of the Society for Neuroscience 2022
Poster
Conference
2022
Montani C., Hayward A., Gutierrez-Barragan D., Morelli G., Alvino F., Coletta L., Galbusera A., Rocchi F., Pasqualetti M., Cancedda L., Gozzi A.
Chemogenetic stimulation of oxytocinergic neurons dynamically modulates fMRI connectivity
FENS Forum 2022
Poster
Conference
2022
POTENZIERI A., UCCELLA S., PREITI D., ROSATI S., LAVARELLO C., DEBELLIS D., CATALANO F., MAROTTA R., PETRETTO A., TUCCI V., RAMENGHI L., SAVARDI A., CANCEDDA L.
Early IGF-1 Receptor Inhibition in Mice Mimics Preterm Human Brain Disorders
Annual Meeting of the Society for Neuroscience 2022
Poster
Conference
2022
Savardi A., Malizia A.P., De Vivo M., Cancedda L., Borgogno M.
Preclinical development of the NKCC1 inhibitor ARN23746 for the treatment of neurodevelopmental disorders
ACS Pharmacology & Translational Science
Article in Press
Journal
2022
Zhao Y., Roy K., Vidossich P., Cancedda L., De Vivo M., Forbush B., Cao E.
Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nature Communications, vol. 13, (no. 1)
2021
Cancedda L.
Associate Editor
Frontiers in Neurodevelopment
Editorial
Journal
2021
Portioli C., Ruiz Munevar M.J., De Vivo M., Cancedda L.
Cation-coupled chloride cotransporters: chemical insights and disease implications
Trends in Chemistry, vol. 3, (no. 10), pp. 832-849
2021
Borgogno M., Savardi A., Manigrasso J., Turci A., Portioli C., Ottonello G., Bertozzi S.M., Armirotti A., Contestabile A., Cancedda L., De Vivo M.
Design, Synthesis,In VitroandIn VivoCharacterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in down Syndrome
Journal of Medicinal Chemistry, vol. 64, (no. 14), pp. 10203-10229
2021
Savardi A., Borgogno M., Summa M., Bertorelli R., Armirotti A., Contestabile A., De Vivo M., Cancedda L.
Discovery and characterization of selective NKCC1 inhibitors to rescue core symptoms in Down syndrome, autism and brain disorders with defective NKCC1/KCC2 ratio.
49th Meeting of the European Brain and Behaviour Society
Poster
Conference
2021
Potenzieri A., Savardi A., Uccella S., Preiti D., De Angelis L., Tucci V., Ramenghi L., Cancedda L.
Early IGF1 Receptor Inhibition Leads to Synaptic Deficits & Impaired Behavior: Implications for Preterm Newborns
49th Meeting of the European Brain and Behaviour Society
Poster
Conference
2021
Savardi A., Borgogno M., De Vivo M., Cancedda L.
Pharmacological tools to target NKCC1 in brain disorders
Trends in Pharmacological Sciences, vol. 42, (no. 12), pp. 1009-1034
2021
Parrini M., Naskar S., Alberti M., Colombi I., Morelli G., Rocchi A., Nanni M., Piccardi F., Charles S., Ronzitti G., Mingozzi F., Contestabile A., Cancedda L.
Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome
Molecular Therapy, vol. 29, (no. 10), pp. 3072-3092