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Roberto Fiammengo

Researcher
Team Leader

Research Line

Nanotechnologies for Humans and Biosystems

Center

CBN@UniLe Lecce

Contacts

Via Barsanti, 73010 Arnesano (Lecce)
+39 0832 1816 228
Contact Me

Social profiles

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About

Education

1998-2002            Ph. D. in Chemistry University of Twente, The Netherlands.

1991-1997              Degree in Chemistry (grade 110/110) University of Padova, Italy.

Professional Experience

03/12-now             Team Leader - Researcher, Center for Biomolecular Nanotechnologies, Italian Institute of Technology, Lecce, Italy.

Peptide and oligonucleotide modified gold nanoparticles, multifunctional nanoparticles.

11/2006-02/2012   Group leader, Department of New Materials and Biosystems, Max-Planck-Institute for Metals Research, Stuttgart, Germany.

Preparation of peptide-modified gold nanoparticles for the site-selective targeting of NMDA-receptors. PEG-based hydrogels as artificial extracellular matrix.

03/2003-11/2006   Post-doctoral researcher, Institute of Pharmacy and Molecular Biotechnology (IPMB), University of Heidelberg, Germany.

Synthesis of modified nucleosides and nucleic acids. Hybrid catalysts and study of organometallic transformations in aqueous medium.

07/2002-03/2003   Post-doctoral researcher, Organic Chemistry Department, University of Padova, Italy.

Synthesis and study of synthetic metallonucleases.

09/1998-06/2002   Ph. D. student, Laboratory of Supramolecular Chemistry and Technology and MESA+ Research Institute, University of Twente, The Netherlands (Prof. David N. Reinhoudt).

Supramolecular chemistry, self-assembly in aqueous solutions, synthesis of biomimetic O2 binders and activators.

11/1997-08/1998     Research fellow, Organic Chemistry department, University of Padova.

Peptide chemistry and synthesis of novel conformationally constrained peptides as ligands for enantioselective metal-catalyzed reactions.

06/1996-10/1997     Master thesis student, degree in Chemistry + four months research fellow at the Organic Chemistry department, University of Padova (Prof. Fulvio di Furia, Dr. Giulia Licini).

Ti-catalyzed sulfoxidation reactions and cycloaddition reactions.

 

Languages           Italian (mother tongue), English (fluent), German (fluent)

Projects

Current research projects:

Development of functionalizable poly(ethylene glycol) (PEG)-based coatings for nanoparticles

Application of biofunctionalized gold nanoparticles:

  1. in diagnostics: quantification of microRNAs in sample of extracted total RNA.
  2. in nanomedicine: selective targeting of receptors on the cell surface (NMDA receptor, leptin receptor); development of nanoparticle-based anticancer vaccines.

Development of silver-nanoparticle-based conductive inks.


External funding:


2014 - 2015 ISSF Network of Excellence scheme award (Wellcome Trust Institutional Strategic Support Fund) with Dr Iain Dunlop, Professor David Dexter, Dr Alexandra Porter (Departments of Materials and Medicine, Imperial College London, UK).

2017 - 2020 CoPI PRIN project 2015RNWJAM " Nanoplatforms for enhanced immune responses " financed by the Italian Ministry of Education, Universities and Research (total 329 k€)

Selected Publications

  1. Compañón, I.; Guerreiro, A.; Mangini, V.; Castro-López, J.; Escudero-Casao, M.; Avenoza, A.; Busto, J. H.; Castillón, S.; Jiménez-Barbero, J.; Asensio, J. L.; Jiménez-Osés, G.; Boutureira, O.; Peregrina, J. M.; Hurtado-Guerrero, R.; Fiammengo, R.* ; Bernardes, G. J. L.* ; Corzana, F.*  Structure-based design of potent tumor-associated antigens: modulation of peptide presentation by single atom O/S or O/Se substitutions at the glycosidic linkage. J. Am. Chem. Soc. 2019, 141, 4063-4072.

  2. Scarpa, E.; Lemma, E. D.; Fiammengo, R.; Cipolla, M. P.; Pisanello, F.; Rizzi, F.; De Vittorio, M. Microfabrication of pH-responsive 3D hydrogel structures via two-photon polymerization of high-molecular-weight poly(ethylene glycol) diacrylates. Sens. Actuators, B 2019, 279, 418-426.

  3. Maggi, V.; Bianchini, F.; Portioli, E.; Peppicelli, S.; Lulli, M.; Bani, D.; Del Sole, R.; Zanardi, F.; Sartori, A.; Fiammengo, R.* Gold nanoparticles functionalized with RGD-semipeptides: a simple yet highly effective targeting system for αVβ3 integrins. Chem. Eur. J. 2018, 24, 12093-12100.

  4. Fiammengo, R.* Can nanotechnology improve cancer diagnosis through miRNA detection? Biomarkers Med. 2017, 11, 69-86.

  5. Perinot, A.; Kshirsagar, P.; Malvindi, M. A.; Pompa, P. P.; Fiammengo, R.*; Caironi, M.* Direct-written polymer field-effect transistors operating at 20 MHz. Sci. Rep. 2016, 6, 38941.

  6. Gonzalez-Carter, D.; Goode, A. E.; Fiammengo, R.; Dunlop, I. E.; Dexter, D. T.; Porter, A. E. Inhibition of leptin–ObR interaction does not prevent leptin translocation across a human blood‑brain barrier model. J. Neuroendocrinol. 2016, doi: 10.1111/jne.12392.

  7. Cai, H.; Degliangeli, F.; Palitzsch, B.; Gerlitzki, B.; Kunz, H.; Schmitt, E.*; Fiammengo, R.*; Westerlind, U.* Glycopeptide-functionalized gold nanoparticles for antibody induction against the tumor associated mucin-1 glycoprotein. Bioorg. Med. Chem. 2016, 24, 1132–1135.

  8. Degliangeli, F.; Pompa, P. P.; Fiammengo, R.* Nanotechnology-based strategies for the detection and quantification of microRNA. Chem. Eur. J. 2014, 20, 9476–9492.

  9. Degliangeli, F.; Kshirsagar, P.; Brunetti, V.; Pompa, P. P.*; Fiammengo, R.* Absolute and direct microRNA quantification using DNA–gold nanoparticle probes. J. Am. Chem. Soc. 2014, 136, 2264-2267.

  10. Valentini, P.; Fiammengo, R.; Sabella, S.; Gariboldi, M.; Maiorano, G.; Cingolani, R.; Pompa, P. P. Gold-nanoparticle-based colorimetric discrimination of cancer-related point mutations with picomolar sensitivity. ACS Nano 2013, 7, 5530-5538.

  11. Brunetti, V.; Chibli, H.; Fiammengo, R.; Galeone, A.; Malvindi, M.A.; Vecchio, G.; Cingolani, R.; Nadeau, J.L.; Pompa, P.P. InP/ZnS as a safer alternative to CdSe/ZnS core/shell quantum dots: in vitro and in vivo toxicity assessment. Nanoscale 2013, 5, 307-317.

  12. Lee-Thedieck, C.; Rauch, N.; Fiammengo, R.; Klein, G.; Spatz, J.P. Impact of substrate elasticity on human hematopoietic stem and progenitor cell adhesion and motility. J. Cell Sci. 2012, 125, 3765-3775.

  13. Maus, L.; Dick, O.; Bading, H.; Spatz, J. P.; Fiammengo, R.* Conjugation of Peptides to the Passivation Shell of Gold Nanoparticles for Targeting of Cell-Surface Receptors. ACS Nano 2010, 4, 6617-6628.

  14. Aydin, D.; Louban, I.; Perschmann, N.; Blummel, J.; Lohmueller, T.; Cavalcanti-Adam, E. A.; Haas, T. L.; Walczak, H.; Kessler, H.; Fiammengo, R.*, Spatz, J. P.* Polymeric substrates with tunable elasticity and nanoscopically controlled biomolecule presentation. Langmuir 2010, 26, 15472-15480.

  15. Maus, L.; Spatz, J. P.; Fiammengo, R.* Quantification and reactivity of functional groups in the ligand shell of PEGylated gold nanoparticles via a fluorescence-based assay. Langmuir 2009, 25, 7910-7917.

Awards

2017  Italian National Scientific Habilitation (ASN) as full professor in Organic Chemistry (from 06/12/2017 until 06/12/2023)

2014  Italian National Scientific Habilitation (ASN) as associate professor in Organic Chemistry (from 14/11/2014 until 14/11/2020)

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