Back to list

Roberto Fiammengo

Researcher
Team Leader

Research Line

Nanotechnologies for Humans and Biosystems

Center

CBN@UniLe Lecce

Contacts

Via Barsanti, 73010 Arnesano (Lecce)
+39 0832 1816 228
Contact Me

Social profiles

linkedin researchgate googlescholar publons

About

Education

1998-2002            Ph. D. in Chemistry University of Twente, The Netherlands.

1991-1997              Degree in Chemistry (grade 110/110) University of Padova, Italy.

Professional Experience

03/12-now             Team Leader - Researcher, Center for Biomolecular Nanotechnologies, Italian Institute of Technology, Lecce, Italy.

Peptide and oligonucleotide modified gold nanoparticles, multifunctional nanoparticles.

11/2006-02/2012   Group leader, Department of New Materials and Biosystems, Max-Planck-Institute for Metals Research, Stuttgart, Germany.

Preparation of peptide-modified gold nanoparticles for the site-selective targeting of NMDA-receptors. PEG-based hydrogels as artificial extracellular matrix.

03/2003-11/2006   Post-doctoral researcher, Institute of Pharmacy and Molecular Biotechnology (IPMB), University of Heidelberg, Germany.

Synthesis of modified nucleosides and nucleic acids. Hybrid catalysts and study of organometallic transformations in aqueous medium.

07/2002-03/2003   Post-doctoral researcher, Organic Chemistry Department, University of Padova, Italy.

Synthesis and study of synthetic metallonucleases.

09/1998-06/2002   Ph. D. student, Laboratory of Supramolecular Chemistry and Technology and MESA+ Research Institute, University of Twente, The Netherlands (Prof. David N. Reinhoudt).

Supramolecular chemistry, self-assembly in aqueous solutions, synthesis of biomimetic O2 binders and activators.

11/1997-08/1998     Research fellow, Organic Chemistry department, University of Padova.

Peptide chemistry and synthesis of novel conformationally constrained peptides as ligands for enantioselective metal-catalyzed reactions.

06/1996-10/1997     Master thesis student, degree in Chemistry + four months research fellow at the Organic Chemistry department, University of Padova (Prof. Fulvio di Furia, Dr. Giulia Licini).

Ti-catalyzed sulfoxidation reactions and cycloaddition reactions.

 

Languages           Italian (mother tongue), English (fluent), German (fluent)

Projects

Current research projects:

Development of functionalizable poly(ethylene glycol) (PEG)-based coatings for nanoparticles

Application of biofunctionalized gold nanoparticles:

  1. in diagnostics: quantification of microRNAs in sample of extracted total RNA.
  2. in nanomedicine: selective targeting of receptors on the cell surface (NMDA receptor, leptin receptor); development of nanoparticle-based anticancer vaccines.

Development of silver-nanoparticle-based conductive inks.


External funding:


2014 - 2015 ISSF Network of Excellence scheme award (Wellcome Trust Institutional Strategic Support Fund) with Dr Iain Dunlop, Professor David Dexter, Dr Alexandra Porter (Departments of Materials and Medicine, Imperial College London, UK).

2017 - 2020 CoPI PRIN project 2015RNWJAM " Nanoplatforms for enhanced immune responses " financed by the Italian Ministry of Education, Universities and Research (total 329 k€)

Selected Publications

  1. Compañón, I.; Guerreiro, A.; Mangini, V.; Castro-López, J.; Escudero-Casao, M.; Avenoza, A.; Busto, J. H.; Castillón, S.; Jiménez-Barbero, J.; Asensio, J. L.; Jiménez-Osés, G.; Boutureira, O.; Peregrina, J. M.; Hurtado-Guerrero, R.; Fiammengo, R.* ; Bernardes, G. J. L.* ; Corzana, F.*  Structure-based design of potent tumor-associated antigens: modulation of peptide presentation by single atom O/S or O/Se substitutions at the glycosidic linkage. J. Am. Chem. Soc. 2019, 141, 4063-4072.

  2. Scarpa, E.; Lemma, E. D.; Fiammengo, R.; Cipolla, M. P.; Pisanello, F.; Rizzi, F.; De Vittorio, M. Microfabrication of pH-responsive 3D hydrogel structures via two-photon polymerization of high-molecular-weight poly(ethylene glycol) diacrylates. Sens. Actuators, B 2019, 279, 418-426.

  3. Maggi, V.; Bianchini, F.; Portioli, E.; Peppicelli, S.; Lulli, M.; Bani, D.; Del Sole, R.; Zanardi, F.; Sartori, A.; Fiammengo, R.* Gold nanoparticles functionalized with RGD-semipeptides: a simple yet highly effective targeting system for αVβ3 integrins. Chem. Eur. J. 2018, 24, 12093-12100.

  4. Fiammengo, R.* Can nanotechnology improve cancer diagnosis through miRNA detection? Biomarkers Med. 2017, 11, 69-86.

  5. Perinot, A.; Kshirsagar, P.; Malvindi, M. A.; Pompa, P. P.; Fiammengo, R.*; Caironi, M.* Direct-written polymer field-effect transistors operating at 20 MHz. Sci. Rep. 2016, 6, 38941.

  6. Gonzalez-Carter, D.; Goode, A. E.; Fiammengo, R.; Dunlop, I. E.; Dexter, D. T.; Porter, A. E. Inhibition of leptin–ObR interaction does not prevent leptin translocation across a human blood‑brain barrier model. J. Neuroendocrinol. 2016, doi: 10.1111/jne.12392.

  7. Cai, H.; Degliangeli, F.; Palitzsch, B.; Gerlitzki, B.; Kunz, H.; Schmitt, E.*; Fiammengo, R.*; Westerlind, U.* Glycopeptide-functionalized gold nanoparticles for antibody induction against the tumor associated mucin-1 glycoprotein. Bioorg. Med. Chem. 2016, 24, 1132–1135.

  8. Degliangeli, F.; Pompa, P. P.; Fiammengo, R.* Nanotechnology-based strategies for the detection and quantification of microRNA. Chem. Eur. J. 2014, 20, 9476–9492.

  9. Degliangeli, F.; Kshirsagar, P.; Brunetti, V.; Pompa, P. P.*; Fiammengo, R.* Absolute and direct microRNA quantification using DNA–gold nanoparticle probes. J. Am. Chem. Soc. 2014, 136, 2264-2267.

  10. Valentini, P.; Fiammengo, R.; Sabella, S.; Gariboldi, M.; Maiorano, G.; Cingolani, R.; Pompa, P. P. Gold-nanoparticle-based colorimetric discrimination of cancer-related point mutations with picomolar sensitivity. ACS Nano 2013, 7, 5530-5538.

  11. Brunetti, V.; Chibli, H.; Fiammengo, R.; Galeone, A.; Malvindi, M.A.; Vecchio, G.; Cingolani, R.; Nadeau, J.L.; Pompa, P.P. InP/ZnS as a safer alternative to CdSe/ZnS core/shell quantum dots: in vitro and in vivo toxicity assessment. Nanoscale 2013, 5, 307-317.

  12. Lee-Thedieck, C.; Rauch, N.; Fiammengo, R.; Klein, G.; Spatz, J.P. Impact of substrate elasticity on human hematopoietic stem and progenitor cell adhesion and motility. J. Cell Sci. 2012, 125, 3765-3775.

  13. Maus, L.; Dick, O.; Bading, H.; Spatz, J. P.; Fiammengo, R.* Conjugation of Peptides to the Passivation Shell of Gold Nanoparticles for Targeting of Cell-Surface Receptors. ACS Nano 2010, 4, 6617-6628.

  14. Aydin, D.; Louban, I.; Perschmann, N.; Blummel, J.; Lohmueller, T.; Cavalcanti-Adam, E. A.; Haas, T. L.; Walczak, H.; Kessler, H.; Fiammengo, R.*, Spatz, J. P.* Polymeric substrates with tunable elasticity and nanoscopically controlled biomolecule presentation. Langmuir 2010, 26, 15472-15480.

  15. Maus, L.; Spatz, J. P.; Fiammengo, R.* Quantification and reactivity of functional groups in the ligand shell of PEGylated gold nanoparticles via a fluorescence-based assay. Langmuir 2009, 25, 7910-7917.

Awards

2017  Italian National Scientific Habilitation (ASN) as full professor in Organic Chemistry (from 06/12/2017 until 06/12/2023)

2014  Italian National Scientific Habilitation (ASN) as associate professor in Organic Chemistry (from 14/11/2014 until 14/11/2020)

INFORMATIVA SUI COOKIES

Il sito web di IIT utilizza i seguenti tipi di cookies: di navigazione/sessione, analytics, di funzionalità e di terze parti. L'utente può scegliere di acconsentire all'uso dei cookies e accedere al sito. Facendo click su "Maggiori Informazioni" verrà visualizzata l'informativa estesa sui tipi di cookies utilizzati e sarà possibile scegliere se autorizzarli durante la navigazione sul sito.
Maggiori Informazioni
Accetta e chiudi

I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.