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Pietro Baldelli

Affiliated Researcher
consultant scientist

Research Line

Neuroscience and Smart Materials


NSYN@Unige Genova


Via Morego, 30
+39 010 71781 237
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Pietro Baldelli graduated in Biological Science at the University of Genova, he accomplished his PhD studies in Cellular Physiology and Neuroimmunophysiology at the University of Torino and he had a position of Associate Researcher at the Dept. of Molecular Physiology and Biophysic, Baylor College of Medicine, Houston, TX. He came back to Italy with an independent Researcher position at the National Institute for Physics of the Matter, Dept. of Neuroscience, University of Torino and he is actually Consultant Scientist at the IIT and Associate  Professor at the Dept. of Experimental Medicine, University of Genova, where he teaches courses on Human Physiology, Neurophysiology and Electrophysiological Technologies. His main subjects of investigation, in the last 15 years, have been the molecular mechanisms underlying both physiological and pathological processes of the neurotransmission that he has investigated at different levels, from the single synapse to the complexity of the neuronal network by using a combination of various electrophysiological approaches. He developed his research activities in collaboration with leading international scientists, acquiring a recognized experience of quantal analysis in synaptic transmission and plasticity. He has a strong biophysical and neurophysiological background, and a proved experience in the project management and coordination. Pietro Baldelli is author of 43 papers in refereed journals and many others in conference proceedings and books and he has been paper reviewer for: The Journal of Neuroscience, The American Journal of Physiology and The European Journal of Pharmacology

Bibliometric index values (2008 - 2013):

- peer-reviewed full papers (indexed in Scopus): 18

- number of citations : 615

- average IF: 6.35

Total scientific production:

- peer-reviewed full papers (indexed in Scopus): 43

- number of citation from 1996: 1023

- average IF: 5.3

- h-index: 22



A common way to explain seizures is the disruption of the normal balance between excitatory and inhibitory input. Increasing evidence showed that epileptogenetic processes transform a normal neuronal network in a hyperexcitable network through multiple mechanisms of altered synaptic and intrinsic plasticity. Goal of our project is the elucidation of the electrophysiological and molecular mechanisms underlying altered plasticity at the basis of epileptogenesis.

Selected Publications

1 - Cupello A., Baldelli P., Gheri A. and Robello M. (1993). A method for checking the volume of solution microinjected into Xenopus oocytes.Analitycal Biochemestry  213, 172-174. IF 2.67 - 4° decile Biochemical Research Methods

2 - Baldelli P., Cupello, A. and Robello M. (1994). GABAA receptors of rat cerebellar granule cells are potently activated by muscimol but only slightly modulated by the benzodiazepine agonist Flunitrazepam.Amino Acids  6, 155-163. IF 2.172 – 5° decile: Biochemistry and Molecular Biology

3 - Robello M., Baldelli P. and Cupello A. (1994). Modulation by extracellular pH of the activity of GABAa receptors on rat cerebellum granule cells.Neuroscience 61, 4, 833-837.  IF 3.42 - 3° decile  Neuroscience

4 - Neely A., Olcese R., Baldelli P., Wei X., Birnbaumer L. and Stefani E. (1995). Dual activation of the cardiac Ca2+ channel a1C-subunit and its modulation by the b-subunit.American Journal Physiology  268, C732-C740. IF 3.82 – 2° decile Physiology

5 - MosierD., Baldelli P., Delbono O., Smith R.G., Appel S.H. and Stefani E. (1995). Amyotrophic Lateral Sclerosis immunoglobulins increase Ca2+ currents in a motoneuron cell line.Annals of Neurology  37, 102-109 IF 10.74 – 1° decile Neuroscience

6 - Noceti F., Baldelli P., Wey X., Qin N., Toro L., Birnbaumer L. and Stefani E., (1996). Effective gating charge per channel in voltage dependent K+ and Ca2+ channels.Journal of General Physiology 108, 143-155. IF 4.2 – 2° decile: Physiology

 7 - Magnelli V., Baldelli P. and Carbone E. (1998) Antagonist-resistant calcium currents in rat embryo motoneurons.European Journal of Neuroscience 10, 1810-1825.  IF 3.65 – 4° decile: Neuroscience

8 - Baldelli P., Magnelli V. and Carbone E. (1999) Selective up-regulation on P- and R-type Ca2+ channels in rat embryo motoneurons by BDNF.European Journal of Neuroscience 11, 1127-1133. IF 3.65 – 4° decile: Neuroscience

9 - De Jaco A., Ajmone-Cat M.A., Baldelli P., Carbone E., Augusti-Tocco G. and Biagioni S. (2000). Modulation of AchE and voltage activated Na+ channels in ChAT transfected neuroblastoma clones.Journal of Neurochemistry 75, 1123-1131. IF 4.33 – 3° decile: Neuroscience

10 - Baldelli P., Forni P.E. and Carbone E., (2000). BDNF, NT-3 and NGF induce distinct new Ca2+ channels synthesis in developing hippocampal neurons.European Journal of Neuroscience 12, 4017-4032.  IF 3.65 – 4° decile: Neuroscience

11 - Carabelli V., Hernández-Guijo J.M., Baldelli P. and Carbone E., (2001). Direct autocrine inhibition and cAMP-dependent potentiation of single L-type Ca2+ channels in bovine chromaffin cells.Journal of Physiology  532, 73-90. IF 5.14 – 1° decile: Physiology

12 - Carbone E., Carabelli V., Cesetti T., Baldelli P., Hernandez-Guijo J.M., L. Giusta (2001). G protein- and cAMP-dependent modulation of L-channel gating: a multi-functional system to control calcium in neurosecretory cells.European Journal of  Physiology - Pflugers Arch. 442, 801-813. IF 3.36 – 3° decile: Physiology

 13 - Baldelli P., Novara M., Carabelli V., Hernández-Guijo J.M. and Carbone E. (2002). Brain derived neurotrophic factor up-regulates GABAergic transmission in hippocampal neurons through a presynaptic mechanism supported by N- and P/Q-type Ca2+ channels European Journal Neuroscience 16, 2297-2310. IF 3.65 – 4° decile: Neuroscience

14 -  Cesetti T., Hernández-Guijo J.M., Baldelli P., Carabelli V., Carbone E. (2003) Opposite action of b1- and b2-adrenergic receptors on CaV1 L-channel current in rat adrenal chromaffin cells.The Journal of  Neuroscience 23(1), 73-83. IF 7.506 – 1° decile: Neuroscience

 15 - Carabelli V., Giancippoli A., Baldelli P., Carbone E. and Artalejio A.  (2003)  Distinct potentiation of L-type currents and secretion by cAMP in rat chromaffin cells.Biophysical Journal 85(2), 1326-1337. IF 4.507 – 2° decile: Biophysics

 16 - Baldelli P., Hernández-Guijo J. M.,  Carabelli V., Novara M., Cesetti T., Andrés-Mateos E., Montiel C. and Carbone E. (2004). Direct and remote modulation of L-channels in chromaffin cells.Molecular Neurobiology 29(1), 73-96. IF 4.311 – 2° decile: Neuroscience

 17-  Novara M., Baldelli P., Cavallari D., Carabelli V., Giancippoli A. and Carbone E. (2004)  Exposures to cAMP and b-adrenergic stimulation recruits CaV3 T-type channels in rat chromaffin cells through Epac cAMP-receptors proteins.Journal of Phyisiology  558, 433-449. IF 5,14 – 2° decile: Physiology

18 - Ariano P, Baldelli P, Carbone P, Gilardino P,  Lo Giudice A,  Lovisolo L, Manfredotti C, Novara M, Sternschulte H, Vittone E (2005) Cellular adhesion and neuronal excitability on functionalised diamond surfaces.Diamond & Related Materials 14, 669–674  *the authors contribute equally to this work IF 1.988 2° decile: Materials Science, Multidisciplinary

 19 - Baldelli P, Hernandez-Guijo JM, Carabelli V, Carbone E. (2005) Brain-Derived Neurotrophic Factor Enhances GABA Release Probability and Nonuniform Distribution of N- and P/Q-Type Channels on Release Sites of Hippocampal Inhibitory Synapses.The Journal of Neuroscience, 25, 3358 –3368. IF 7.506 – 1° decile: Neuroscience

20 - Baldelli P. Fassio A. Corradi A. Cremona O. Valtorta F. Benfenati F. (2005) Synapsins and neuroexocytosis: recent views from functional studies on synapsin null mutant mice.Archives Italiennes de Biologie. 143,113-26. IF 0.77  – 9° decile: Neuroscience

21 - Giancippoli A., Novara M., de Luca A., Baldelli P., Marcantoni A., Carbone E., and Carabelli V. (2006) Low-threshold exocytosis induced by cAMP-recruited CaV3.2 (1H) channels in rat chromaffin cells. Biophysical Journal90, 1830-1841. IF 4.507 – 2° decile: Biophysics

 22 Collo G., Goffi F., Merlo Pich E., Baldelli; Fabio Benfenati PierFranco Spano (2006) Immature neuronal phenotype derived from mouse skin precursor cells differentiated in vitro Brain Research, 1109, 32-36. IF 2.62 – 6° decile: Neuroscience

 23 – Menegon A., Bonanomi D, AlbertinazziC, LottiF, FerrariG, KaoHT, BenfenatiF, Baldelli Pand Valtorta F (2006) Protein kinase A-mediated synapsin I phosphorylation is a central modulator of Ca2+-dependent synaptic activity.Journal of Neuroscience, 26, 11670 –11681 IF 7.506 – 1° decile: Neuroscience

24 Marcantoni A., Baldelli P., Hernandez-Guijo  H.M., Comunanza V., Carabelli V., Carbone E. (2007) L-type calcium channels in adrenal chromaffin cells: role in pace-making and secretion.Cell Calcium 42, 397-408 IF 4.939 – 3° decile: Cell Biology

25 - Baldelli P., Fassio A., Valtorta F., Benfenati F. (2007) Lack of Synapsin I Reduces the Readily Releasable Pool of Synaptic Vesicles at Central Inhibitory Synapses The Journal of Neuroscience, 27, 13520 –13531  IF 7.506 – 1° decile: Neuroscience

26- Arnaiz-Cot J.J., González J.C., Sobrado M., Baldelli P., Carbone E., Gandía L., García A.G. and Hernández-Guijo J.M. (2008) Allosteric modulation of alfa-7 nicotinic receptors selectively depolarizes hippocampal interneurons enhancing spontaneous GABAergic transmission.European Journal Neuroscience, 27, 1097-1110 IF 3.65 – 4° decile: Neuroscience

27- Chiappalone M, Casagrande S, Tedesco MT, Valtorta F, Baldelli P, Martinoia S and Benfenati F (2009) Opposite Changes in Glutamatergic and GABAergic Transmission Underlie the Diffuse Hyperexcitability of Synapsin I-Deficient Cortical Networks.Cerebral Cortex 19, 1422-1439 IF 6.84 – 1° decile: Neuroscience

28 Bianchi V, Farisello P, Baldelli P, Meskenaite V, Milanese M, Vecellio M, Mühlemann S, Lipp HP, Bonanno G, Benfenati F, Toniolo T and D’Adamo P. (2009) Cognitive impairment in Gdi1 deficient mice is associated with altered synaptic vesicle pools and short-term synaptic plasticity, and can be corrected by appropriate learning training.  Hum Mol Genet. 1, 105-117. IF 7.8 – 1° decile: Genetics and Heredity

 29Musazzi L, Milanese M, Farisello P, Zappettini S, Tardito D, Barbiero VS, Bonifacino T, Mallei A, Baldelli P, Racagni G, Raiteri M, Benfenati F, Bonanno G, Popoli M. (2010)Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressants. PLoS One. Jan 5;5(1):e8566. IF 4.41 – 2° decile: Biology

 30 - Cesca, F. Baldelli P, Valtorta F. and Benfenati F. (2010) The synapsins: Key actors of synapse function and plasticity. Prog. Neurobiol. 91:313-348. IF 11.4 – 1° decile: Neuroscience

 31 - Boido D, Farisello P, Cesca F, Ferrea E, Valtorta F, Benfenati F, and Baldelli P. (2010) Cortico-Hippocampal Hyperexcitability in Synapsin I/II/III Knockout Mice: Age-Dependency and Response to the Antiepileptic Drug Levetiracetam. Neuroscience.  171, 268-83 IF 3.42 - 3° decile  Neuroscience

32 - González J.C., Albiñana E., Baldelli P., García A.G. and Hernández-Guijo J.M. (2011) Presynaptic muscarinic receptor subtypes involved in the enhancement of spontaneous GABAergic postsynaptic currents in hippocampal neurons. European Journal of Neuroscience  33, 69-81. IF 3.65 – 4° decile: Neuroscience

33 – FassioA, Patry L, CongiaS, OnofriF, PitonA, GauthierJ, PozziD, MessaM, De FranchiE, FaddaE, CorradiA, BaldelliP, LapointeL, St-OngeJ, Mottron L, ValtortaF, NguyenDK, RouleauGA, BenfenatiF, Cossette P (2011) SYN1 is an autism predisposing gene: identification of loss-of-function mutations with impaired synaptic function.  Hum Mol Genet. 20(12):2297-307. Epub 2011 Mar 25. IF 7.8 – 1° decile: Genetics and Heredity

34 Fassio A, Raimondi A, Lignani G, Benfenati F and Baldelli P (2011) Synapsins: from synapse to network hyperexcitability and epilepsy. Semin Cell Dev Biol. Jul 26. [Epub ahead of print] IF 5.91 – 2° decile: Developmental Biology

35 - F Cesca, A Yabe, B Spencer-Dene, J Scholz-Starke, L Medrihan, CH Maden, H Gerhardt, IR Orriss, P Baldelli, M Al-Qatari, M Koltzenburg, RH Adams, F Benfenati and G Schiavo. (2011) Kidins220/ARMS Mediates the Integration of the Neurotrophin and VEGF Pathways in the Vascular and Nervous Systems Cell Death Differ. doi: 10.1038/cdd.2011.141. [Epub ahead of print] IF 9.05 – 1° decile: Biochemistry and Molecular Biology

36 - P Farisello; D Boido; T Nieus; L Medrihan; F Cesca; FValtorta; PBaldelli; F Benfenati (2012) Synaptic and Extrasynaptic Origin of the Excitation/Inhibition Imbalance in the Hippocampus of Synapsin I/II/III Knockout MiceCereb Cortex. 2013 Mar;23(3):581-93. doi: 10.1093/cercor/bhs041. Epub 2012 Feb 24. IF 6.84 – 1° decile: Neuroscience 

37 - Scholz-Starke J, Cesca F, Schiavo G, Benfenati F, Baldelli P. Kidins220/ARMS is a novel modulator of short-term synaptic plasticity in hippocampal GABAergic neurons. PLoS One. 2012;7(4):e35785. Epub 2012 Apr 26.PMID: 22563401. IF 4.41 – 2° decile: Biology

38 - Valente P, Casagrande S, Nieus T, Verstegen AM, Valtorta F, Benfenati F, Baldelli P.(2012) Site-specific synapsin I phosphorylation participates in the expression of post-tetanic potentiation and its enhancement by BDNF.J Neurosci. 2012 Apr 25;32(17):5868-79. IF 7.506 – 1° decile: Neuroscience

39 - Marconi E, Nieus T, Maccione A, Valente P, Simi A, Messa M, Dante S, Baldelli P, Berdondini L, Benfenati F.Emergent functional properties of neuronal networks with controlled topology.PLoS One. 2012;7(4):e34648. Epub 2012 Apr 6.  IF 4.41 – 2° decile: Biology

40 - Ferrea E, Maccione A, Medrihan L, Nieus T, Ghezzi D, Baldelli P, Benfenati F and Berdondini L   (2012) Large-scale, high-resolution electrophysiological imaging of field potentials in brain slices with microelectronic multielectrode arrays    Frontiers in Neural Circuits   VOLUME=6  DOI=10.3389/fncir.2012.00080  ISSN=1662-5110   IF 5.1 – 2° decile: Neuroscience  

41- Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity. Lignani G, Raimondi A, Ferrea E, Rocchi A, Paonessa F, Cesca F, Orlando M, Tkatch T, Valtorta F, Cossette P, Baldelli P, Benfenati F. Hum Mol Genet. 2013 Mar 1. [Epub ahead of print] IF 7.8 – 1° decile: Genetics and Heredity

42 - González JC, Lignani G, Maroto M, Baldelli P, Hernández-Guijo JM. Presynaptic Muscarinic Receptors Reduce Synaptic Depression and Facilitate its Recovery at Hippocampal GABAergic Synapses.Cereb Cortex. 2013 Feb 20. [Epub ahead of print] IF 6.84 – 1° decile: Neuroscience

43- Medrihan L, Cesca F, Raimondi A, Lignani G, Baldelli P, Benfenati F.Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.Nat Commun. 2013 Feb 26;4:1512. doi: 10.1038/ncomms2515. IF 7.4– 1° decile: Multidisciplinary


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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.