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Miguel Moreira

Post Doc
Post-Doc Researcher Nanotechnology for Precision Medicine

Research Line

Nanotechnology for Precision Medicine

Center

IIT Central Research Labs Genova

Contacts

rua Lugar Novo N134 Meinedo, Lousada
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About

Dr Miguel Moreira is a Post Doc in the Nanotechnology for Precision Medicine Laboratory since 2015.

He is currently working on the synthesis and preparation of polymeric nanoconstructs with optimized relaxivity for the imaging of cancer and cardiovascular diseases. He is in charge of the preparation of prodrugs for an efficient loading and release from the nanoconstructs and he performs in vitro studies for assessment of the stability and release of the prodrugs from the nanoconstrctus.

Dr Moreira achieved his M.Sc in Medicinal Chemistry at the University of Minho in 2009. He presented an experimental thesis titled “Paramagnetic gold nanoparticles for MRI and therapeutic applications” under the supervision of Dr José Alberto Martins. He furthered his education with a Ph.D in Sciences, in the specialty of Chemistry at the University of Minho in 2014. He defended a thesis titled: “Optimized Molecular Imaging Agents: from Metal Chelates to Micelles and Gold Nanoparticles” for which he was funded by FCT-Portugal.

During his doctoral training, he developed a general synthetic route for the synthesis of bifunctional -thiol derivatized metal chelators for the preparation of paramagnetic gold nanoparticles for MRI. He also worked on the preparation, metal-loading and purification of functionalized gold nanoparticles. Another task he performed was the relaxometric characterization of the paramagnetic nanoparticles by 17O and 1H NMRD profiles studies in order to assess the performance of the nanoparticles as MRI CA’s and to determine the parameters that govern relaxivity. Evaluation of the effect of size and charge on the behavior of the nanoparticles in vivo through Biodistribution studies in Wistar rats.

During his Ph.D, he conducted work under the orientation of Eva Toth PhD, CNRS in Orleans, France, over a period of 1 month. He also collaborated under the supervision of Gonçalo Bernardes PhD in Cambridge, UK, over a period of 3 months.

Before joining IIT, he was a Post Doc Researcher at the Dept. Polymers and composites, University of Minho, Guimarães, Portugal, working on the chemical modification of quantum dots obtained using different methodologies, in order to control its solubility in different solvents.

Selected Publications

- Gonçalves, Catarina; Silva, João; F. Antunes, Inês; Ferreira, Miguel; Martins, José; Geraldes, Carlos; Lalatonne, Yoann; Motte, Laurence; De Vries, Erik; Gama, Francisco; “Dextrin nanomagnetogel as dual modality imaging bioprobe” Bioconjugate Chem; DOI: 10.1021/acs.bioconjchem.5b00024


- Miguel F. Ferreira, Janaina Gonçalves, B. Mousavi, M. I. M. Prata, P. J. Rodrigues, Pilar López-Larrubia,Sebastian Cerdan, Tiago B. Rodrigues, L. Helm, José A. Martins and Carlos F.G.C. Geraldes; “Gold nanoparticles functionalised with Gd3+chelates: effect of linkers on the relaxivity” Dalton Transactions, 2015 Feb 17; 44(9); 4016-31, DOI: 10.1039/C4DT03210A.


- M. F. Ferreira, G. Pereira, A. F. Martins, C. I. O. Martins, M. I. M. Prata, S. Petoud, E. Toth, P. M. T. Ferreira, J. A. Martins, C. F. G. C. Geraldes; “Ln[DO3A-N-alfa-(pyrenebutanamido)propionate] complexes: optimized relaxivity and NIR optical properties”; Dalton Trans. 2014, 43(8), 3162-73.DOI: 10.1039/c3dt52958d

- Miguel F. Ferreira, Goretti Pereira, João P. André, M. I. M. Prata, Paula M. T. Ferreira, José A. Martins, Carlos F. G. C. Geraldes; “Ga[(NO2A-N-(-amino)propionate)] chelates: synthesis and evaluation as potential tracers for 68Ga3+ PET”;Dalton Trans., 2014,43, 8037-8047.DOI:10.1039/C4DT00386A.

- Ferreira, M. F.; Martins, A. F.; Martins, C. I. O.; Ferreira, P. M.; Toth, E.; Rodrigues, T. B.; Calle, D.; Cerdan, S.; Lopez-Larrubia, P.; Martins, J. A.; Geraldes, C F. G. C.;“Amide conjugates of the DO3A-N-(-amino)propionate ligand: leads for stable, high relaxivity contrast agents for MRI?”; Contrast Med. Mol. Imaging 2013, 8(1), 40-49. DOI: 10.1002/cmmi.1492

- Gonçalves, C.; Lalatone, Y.; Melro, L.; Badino, G.; Ferreira, M.F.M.; David, L.; Geraldes, C.F.G.C.; Motte, L.; Martins, J.A.; Gama, F.M;“New dextrin nanomagnetogels as contrast agents for Magnetic Resonance Imaging”;J. Mater. Chem. B, 2013,1, 5853-5864. DOI: 10.1039/C3TB21063D

- M. F. Ferreira, B. Mousavi, P. M. Ferreira, C. I. O. Martins, L. Helm, J. A. Martins and C. F. G. C. Geraldes; “Gold nanoparticles functionalised with stable, fast water exchanging Gd3+chelates as high relaxivity contrast agents for MRI”; Dalton Trans., 2012, 41, 5472-5475. DOI: 10.1039/c2dt30388d.

- Goreti Pereira, Miguel F. Ferreira, Elisabete M. S. Castanheira, José A. Martins, Paula M. T. Ferreira; “Synthesis of 2,6-Bis(oxazolyl)pyridine Ligands for Luminescent LnIII Complexes”; Volume 2012, Issue 21, pages 3905–3910, July 2012. DOI: 10.1002/ejoc.201200177.

- C Gonçalves, M F M Ferreira, A C Santos, M I M Prata, C F G C Geraldes, J A Martins and F M Gama; “Studies on the biodistribution of dextrin nanoparticles”, Nanotechnology 21 (2010),295103. DOI:10.1088/0957-4484/21/29/295103.

- M.F. Ferreira, A.F. Martins, J.A. Martins, P.M. Ferreira, E. Toth, C.F.G.C. Geraldes;"Gd(DO3A-N--aminopropionate: a versatile and easily available synthon with optimized water exchange for the synthesis of high relaxivity, targeted MRI contrast agents", Chem. Commun., 2009, 6475-6477. DOI:10.1039/B912201J.

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