Rita Scarpelli studied at the University of Rome ‘La Sapienza’ (Italy) where she earned her Degree in Chemistry (1995) and a Ph.D. in Organic Chemistry (1998). She joined then the group of Professor K.C. Nicolaou at The Scripps Research Institute, La Jolla, (CA, USA) as Postdoctoral Research Associate. After this experience, she moved to the University of Rome ‘Tor Vergata’ (Italy) where she became Researcher (C06X) at the Department of Chemical Science and Technologies (2000). In 2001, she started her carrier in the pharmaceutical industry, joining the Medicinal Chemistry Department of Merck Sharp & Dohme at Istituto di Ricerche di Biologia Molecolare (IRBM)-Merck Research Laboratories (MRL) in Pomezia (Rome, Italy) as Senior Research Chemist. In IRBM-MRL, she worked on different drug discovery programs and gave key contributions, as team member, to the discovery of two drugs, currently on the market: Raltegravir - Isentress® (antiviral, HIV integrase inhibitor) and Niraparib - Zejula® (anti-cancer, poly(ADP-ribose)polymerase inhibitor). In late 2009, she joined Fondazione Istituto Italiano di Tecnologia (IIT) in Genoa (Italy), as Team Leader in Medicinal Chemistry. Since then, her research activity has been focused on the identification of new potential drugs for the treatment of inflammatory, cancer and neurodegenerative diseases. Some of these projects have been funded by international Industrial Partners. She is currently the Coordinator of the Medicinal Chemistry and Technologies for Drug Discovery and Delivery (MCTD3) Facility at IIT. Dr. Scarpelli has published 50 papers in leading international journals and is an inventor in 22 granted patents.
Rita Scarpelli
Medicinal Chemistry And Technologies for Drug Discovery and Delivery
Phone
			              	+39 010 2896 233
	              			Research center
					              	CCT@Morego
				              			Biografia
	              			Top Publications
	                2023
										Palomba M., Vecchio D., Allavena G., Capaccio V., De Mei C., Scarpelli R., Grimaldi B.
										Identification of a Dual Autophagy and REV-ERB Inhibitor with in Vivo Anticancer Efficacy
										Journal of Medicinal Chemistry
									2020
										Caputo S., Di Martino S., Cilibrasi V., Tardia P., Mazzonna M., Russo D., Penna I., Summa M., Bertozzi S.M., Realini N., Margaroli N., Migliore M., Ottonello G., Liu M., Lansbury P., Armirotti A., Bertorelli R., Ray S.S., Skerlj R., Scarpelli R.
										Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors
										Journal of Medicinal Chemistry, vol. 63, (no. 24), pp. 15821-15851
									2020
										Di Martino S., Tardia P., Cilibrasi V., Caputo S., Mazzonna M., Russo D., Penna I., Realini N., Margaroli N., Migliore M., Pizzirani D., Ottonello G., Bertozzi S.M., Armirotti A., Nguyen D., Sun Y., Bongarzone E.R., Lansbury P., Liu M., Skerlj R., Scarpelli R.
										Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors
										Journal of Medicinal Chemistry, vol. 63, (no. 7), pp. 3634-3664
									All Publications
	                2025
										Quaia R., Veronesi M., Anselmi M., Russo D., Penna I., Scarpelli R., Girotto S., Bertozzi F., Duca M., Bandiera T.
										Development of fluorinated fragments into novel modulators of micro-RNA-21 levels
										European School of Medicinal Chemistry – 44th Edition
									
										
											Poster
										
										
											Conference
										
										
									
								2025
										Anselmi M., Russo D., Penna I., Quaia R., Panosetti M., Scarpelli R., Girotto S., Veronesi M., Bertozzi F., Duca M., Bandiera T.
										DISCOVERY OF NOVEL SMALL-MOLECULE MODULATORS OF microRNA-21 IN PANCREATIC CANCER CELLS
										59th International Conference on Medicinal Chemistry
									
										
											Poster
										
										
											Conference
										
										
									
								2025
										Marotta G., Massenzio F., Ortega J., Russo D., Penna I., Falchi F., Babini G., Petralla S., Scarpelli R., Roggiolani E., Fricker G., Rosini M., Cavalli A., Monti B., Minarini A., Basagni F.
										Exploration of the Neuromodulatory Properties of Fyn and GSK-3β Kinases Exploiting 7-Azaindole-Based Inhibitors
										Journal of Medicinal Chemistry
									
										
											Article
										
										
											Journal
										
										
									
								2025
										Quatraccioni M., Ocello R., Falchi F., Previtali V., Veronesi M., Varignani G., Margaroli N., Masi M., Scarpelli R., Girotto S., Cavalli A.
										In search of small molecules targeting RAD52 for synthetic lethality (P120)- September 14-17, 2025, Parma (Italy)
										XXIX National Meeting on Medicinal Chemistry
									
										
											Poster
										
										
											Conference
										
										
									
								2025
										Codino A., Spagnoletti L., Olobardi C., Cuomo A., Santos-Rosa H., Palomba M., Margaroli N., Girotto S., Scarpelli R., Luan S.-L., Crocco E., Bianchini P., Bannister A.J., Gustincich S., Kouzarides T., Rizzo R., Barbieri I., Cremisi F., Vignali R., Pandolfini L.
										METTL9 sustains vertebrate neural development primarily via non-catalytic functions
										Nature Communications, vol. 16, (no. 1)
									Scientific Talks
	                2023
	                						Anselmi M., Russo D., Penna I., Bellina F., Quaia R., Panosetti M., Scarpelli R., Veronesi M., Girotto S., Bertozzi F., Duca M., and Bandiera T.
	                						Discovery of small-molecule modulators of microRNA-21 expression
	                						
	                					Istituto Italiano di Tecnologia
             
									        Institute
										2022
	                						Scarpelli R.
	                						Identification of ARN21641, an orally available and CNS penetrant Acid Ceramidase inhibitor with target engagement in mouse models of Gaucher and Krabbe diseases
	                						
	                					27th National Meeting on Medicinal Chemistry (NMMC27) - Invited Talk (Keynote 6)
             
									        Conference
										2013
	                						Scarpelli R.
	                						Peripherally-restricted FAAH inhibitors as potential analgesic agents
	                						
	                					31st Camerino-Cyprus-Noordwijkerhout Symposium, Receptor Chemistry Skyline. Camerino, Italy
             
									        Conference
										Oral presentations
	                2023
	                						Scarpelli R., Palomba M., Vecchio D., Ottonello G., Mandrup Bertozzi S., Summa M., Armirotti A., Bertorelli R., De Mei C., Grimaldi B.
	                						Identification of a dual REV-ERBβ and autophagy inhibitor with in vivo anticancer efficacy (P222)- September 3-7, 2023, Zagreb (Croatia)
	                						IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry
	                					Conference
										2023
	                						Scarpelli R., Palomba M., Vecchio D., Allavena G., Capaccio V., De Mei C., Grimaldi B.
	                						Lead optimization of the diarylalkyl amine series as dual REV_ERB and autophagy inhibitors with in vivo anticancer efficacy (P83)- September 17-20, 2023, Chieti (Italy)
	                						XXVIII National Meeting on Medicinal Chemistry
	                					Conference