Laura Cancedda graduated in Medicinal Chemistry at the University of Genoa in 1999, with a thesis on the role of neurotrophic factors on neurotransmitter release. She received her Ph.D. in neurophysiology from Scuola Normale Superiore (Pisa, Italy) in 2003, under the supervision of Dr. Lamberto Maffei. In Pisa, she investigated the molecular and environmental basis of experience-dependent plasticity in the rat brain. In 2003, she moved to University of California at Berkeley in Dr. Poo’s laboratory where she focused her studies on molecular mechanisms of GABAergic-transmission modulation. Starting in 2006, she has also started a collaboration on a project aimed at studying early determinants of neuronal polarization.
Currently, she holds a team-leader position at the Italian Institute of Technology (IIT) in Genoa and a scientist position at the Telethon Dulbecco Institute. Laura is also a scholar of the FENS KAVLI network of excellence. Her research focuses on the role of extracellular factors such as GABA in neurogenesis, migration and morphological maturation of cortical neurons under physiological as well as pathological conditions.
Laura comes from a neurophysiological and neuropharmacological background. The techniques applied in her laboratory include, among others,in vitroelectrophysiology on brain slices and cell cultures,in vivotransfection of nucleic acids (in uteroelectroporation),in vitroandin vivopharmacology, immunohistochemistry, and confocal imaging. She also has experience in rodent behavioral testing.In addition to her technical expertise, Laura has substantial writing and editing experience.
2016- The Italian Institute of Technology, Genoa, Italy Senior Researcher (Tenured)
2016- Dulbecco Telethon Institute, Italy, Scientist
2013-2106 The Italian Institute of Technology, Genoa, Italy Senior Team leader
2008-2013 The Italian Institute of Technology, Genoa, Italy Team leader
2003-2007 University of California at Berkeley, USA Post doc. (Advisor: Poo MM)
2004 Chinese Academy of Sciences,Shanghai visiting Fellow (Host: Yuan X)
2000-2003 Scuola Normale Superiore, Pisa, Italy Graduate student (Advisor: Maffei L)
2000 Brain Institute RIKEN Wako-Shi, Japan Visiting Fellow (Host: Hensch TK)
2017 Advisor for the Neuroscience of Fondazione Pisana per la Scienza, Pisa, Italy
Collaboration (with Dr. Vicari, Bambino Gesù Hospital, Rome) on a clinical trial for the treatment of cognitive impairment in individuals with Down Syndrome.
2016 Member of the FENS-KAVLI network of excellence
Member of Ph.D. dissertation committee, Institut du Fer à Moulin, Paris
Teacher of neurodevelopmental physiology at graduate students of the Scuola Normale Superiore, Pisa
2016 Scientific committee for the organization of the DTI-TIGEM-TIGET meeting, Roma, Italy
Member of Ph.D. dissertation committee, Institut du Fer à Moulin, Paris
2015-2009 Member of Ph.D. dissertation committee at Scuola Normale Superiore, Pisa, Italy (once/year)
2014 Guest editor for special issue of Frontiers in Neuroscience on “GABAergic system in CNS development and maldevelopment”
2012 Organizer of the symposium “Activity-dependent modifications of neuronal circuits: plasticity, adaptation and tenacity”, Italian Society of Neuroscience meeting, Italy
2011 Guest editor for special issue of Neural Plasticity on “GABAergic circuit development and its implication for CNS disorders”
2012 Member of dissertation Ph.D. committee Università degli Studi di Pisa, Italy
2004 Organizer of the “Neuro super group” meetings, U.C. Berkeley
Direct commissioned manuscript reviewer: Science, Nature Communications, Cell Reports, PNAS, Journal of Neuroscience, Journal of Physiology, Scientific Reports, European Journal of Neuroscience, Hippocampus, Journal of Neurochemistry, Frontiers in Neuronal Circuits, Frontiers in Cellular Neuroscience, Frontiers in Molecular Neuroscience, Frontiers in Pediatrics, Medical Research archives, Molecular Neurobiology, Brain Structure and Function, PLOS ONE, Journal of Neurochemistry, Developmental Neurobiology, Neuroscience, International Journal of Developmental Neuroscience, OMICS, Molecular Genetics and Metabolism, Neural plasticity, International Journal of Developmental Neuroscience, Neuroscience Letter, Neurochemistry international, World Journal of Surgical Oncology, Bio- and Medical Informatics and Cybernetics (BMIC).
National Science Foundation (NSF), U.S.; H2020- Future and Emerging Technologies (FET) OPEN, EU; FP7-ICT-2011-C (FET), EU; MRC, United Kingdom; French National Research Agency (ANR), France; Novel ideas for radically new technologies, Canada Foundation for Innovation Competition (CFI); Netherlands Organization for Scientific Research (NWO), Netherlands; Irish Research Council (IRC); Seed project, IIT, Italy.
Editorial Board member: Frontiers in Cellular Neuroscience, PeerJ.
Invited Speaker at National and International Meetings:
2018 Invited speaker at the symposium “Drug repurposing for treating genetic disorders” at the European Society of Human Genetics Conference 2018, Milan, Italy.
Invited speaker at the symposium “Autism and Neurodevelopmental Disorders” at the 4th Neurological Disorders Summit, Los Angeles, California, USA
Invited speaker at the Neural Circuit Development and Plasticity” school Utrecht, Nederland.
Invited speaker at the “Autism Spectrum Disorders: developmental trajectories, neurobiological basis, treatment update” meeting, Siena, Italy.
2017 Invited speaker at the 19th International Neuroscience Winter Conference, Solden Austria
Invited speaker at the 38th World Congress of the International Union of Physiological Sciences (IUPS), Rio de Janeiro, Brasil.
Invited speaker at the Telethon Convention, Riva del Garda, Italy
Invited speaker at Neuronal Surfaceome in Circuit Formation meeting, Verbania, Italy
Invited speaker at the The Future of Genetics in Medicine and beyond meeting, Torino, Italy.
Invited speaker at Italian Society for Neuroscience (SINS) meeting, Ischia, Italy.
Invited speaker at the symposium “Therapy for Down Syndrome: dreams or reality?”, Down Syndrome: from diagnosis to therapy Meeting, Napoli, Italy.
2016 Invited speaker at the “Epilepsy and Neuronal Synchronization” Gordon Research Conference, Spain.
Invited speaker at a mini-symposium at the Society for Neuroscience (SFN), San Diego, U.S.
Invited speaker at the Federation of European Neurosciences Societies (FENS) meeting, Copenhagen, Denmark.
Invited speaker at the symposium “Channelopathies”, meeting of the Società Italiana di Genetica Umana (SIGU), Torino, Italy.
Invited speaker at the Telethon (TIGEM, TIGET, DTI) three-retreat, Rome, Italy.
2015 Invited speaker at the “Inhibition in the CNS” Gordon Research Conference, United States.
2014 Invited speaker and invited chair of the “Molecular Neuroscience" session at Neuronus meeting, Krakow, Poland.
2013 Invited speaker at the Engineering in Medicine and Biology Society (IEEE-EMBS) annual conference, Osaka, Japan.
2012 Invited speaker and invited chair of the at Jacques Monod conference “Mechanisms of intellectual disabilities: from genes to treatment”, Roscoff, France.
Invited speaker Italian Society of Neuroscience (SINS) meeting, Italy.
Selected for oral presentation at the meeting “Cell biology of the neuron: polarity, plasticity and regeneration”, Crete, Greece.
2011 Selected for oral presentation at the meeting “Wiring the brain: making connections”, Powerscout, Co Wikcklow, Ireland.
2010 Invited speaker at the symposium “Neuronal Development, Neurotransmission and Neurodegeneration”, Italian Society of Biochemistry (SIB) meeting.
Invited speaker, “Plasticise” meeting, Pisa, Italy.
Invited speaker, “NeuroIITScience”, Genoa, Italy.
2009 Invited speaker Minisymposium “Depolarizing GABA in development, maldevelopment and seizures: friend or foe?” Society for Neuroscience (SFN), 2009.
The presentation was included in the “Hot Topic” database Neuroscience, 2009
Invited speaker at the Symposium “Neurodevelopmental alterations leading to epilepsy”, Italian Society for Neuroscience (SINS).
2008 Invited speaker, Scientific Seminary Session, Scuola Normale Superiore, Pisa, Italy.
Selected for oral presentation, Molecular Mechanisms in Neuroscience meeting, Italian Society for Neuroscience (SINS), Milan, Italy.
2017-2022 European Research Council (ERC) advanced. Rescuing Cognitive Deficits in Neurodevelopmental Disorders by Gene Editing in Brain Development: the Case of Down Syndrome (GenEdiDS).
2016-2021 Telethon Foundation (Italy) Coordinator Targeting aberrant Cl- homeostasis and GABAA transmission to design innovative therapeutic approaches in Down syndrome. (Career grant.)
2014-2015 Lejeune Foundation (France) PI Experimental and clinical evaluation of a clinically-used Cl transporter inhibitor to rescue cognitive functions by reverting excitatory GABA in Down syndrome.
2014-2017 Telethon Foundation PI Unravelling the Rett syndrome: effects of MeCP2 mutations on synaptic function.
2014-2016 Lejeune Foundation (France) Co-PI Targeting neurotrophin signaling to rescue synaptic plasticity and cognitive functions in a mouse model of Down syndrome.
2014-2016 Cariplo Bank PI Phenotype characterization of PCDH19 mutations underlying “Epilepsy with Mental Retardation limited to Females” (EFMR) syndrome using in vitro and in vivo models.
2015 GOAP (Bayer, Germany) Co-PI Gene editing to treat genetic photoreceptor degeneration.
2013-2015 Lejeune Foundation (France) Co-PI Safe modulation of GABAergic transmission by clinically-tested drugs to rescue cognitive functions in Ts65Dn mice.
2013-2015 Interdisciplinary project IIT Coordinator Novel site-directed in utero electroporation by temporal modulation of a multi-electrode array.
2010-2014 Telethon Foundation PI Role of GABAA-receptor mutations in idiopatic generalized epilepsy and development.
2011-2013 Research Ministry Consultant In vivo and in vitro morpho functional analysis of neuronal populations in rodent models of Rett syndrome, the MeCP2 null mice and in animals transfected in utero with different forms of mutated MeCP2.
2009-2013 Compagnia di San Paolo Coordinator Early interference with GABA action by exposure to therapeutic drugs: circuit development, epilepsy and cognition.
The main goal of my laboratory is to understand the molecular determinants of cortical circuit development and wiring in physiology and pathology. In particular, I am interested in how extracellular factors and especially non-hyperpolarzing GABAergic signaling modulate neuronal migration, axon and dendrite formation, and neuronal connectivity. In order to achieve this goal, we use a combination of in vivoand in vitro approaches ranging from electrophysiology and neuroanatomy to biochemistry and molecular biology.
Current laboratory members:
Mohit Rastogi (graduate student)
Ilias Ziogas (graduate student)
Maria Bolla (graduate student)
Annalisa Savardi (graduate student)
Bruno Pinto (graduate student)
Micol Alberti (graduate student, under Andrea Contestabile supervision)
Corinne Portioli (postdoc)
Giovanni Morelli (postdoc)
Salvatore Magara (postdoc)
Roberto Narducci (postdoc)
Marina Nanni (junior technician)
Andrea Contestabile (senior technician)
Former laboratory members:
Guillaume Bony (graduate student), currently at Neurocentre Magendie, Bordeaux; Andreas Frick Laboratory
Ilaria Tamagno (junior post-doc), currently at Lerner Research Institute Cleveland Clinic.
Gabriele Deidda (graduate student), currently at Cardiff University (UK), Crunelli V lab
Laura Perlini (junior post doc), currently Journal Manager at Frontiers in Neurology and Frontiers in Psychiatry
Alessandro Alabastri Postdoctoral fellow, currently at Rice University (U.S.A)
Francesco Gentile Postdoctoral fellow currently assistant professor at Naples University (Italy)
Ignacio Fernandez (graduate student)
Andrzej Cwetsch (graduate student), currently at the Jacques Monod Institute, Paris, France
Shovan Naskar (graduate student), currently at the National Health Institute (NIH), US
Martina Parrini (graduate student), currently at Friedrich Miescher Institute for Biomedical Research, Basel (Switzerland), Caroni P lab
Last Author Research Publications:
Naskar S, Roberto Narducci R, Balzani E, Cwetsch A.W. Tucci V*, Cancedda L* (2019). The development of synaptic transmission is time-locked to early social behaviors in rats. Nature Communications, in press.
Szczurkowska J, Pischedda F, Pinto B, Managò F, Haas CA, Summa M, Bertorelli R, Papaleo F, Schäfer MK, Piccoli G, Cancedda L (2018). NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice. Brain, Sep 1;141(9):2772-2794.
Szczurkowska J, Cwetsch AW, Dal Maschio M, Ghezzi D, Ratto GM, Cancedda L (2016). Targeted in vivo genetic manipulation of the mouse or rat brain by in utero electroporation with a triple-electrode probe. Nature Protocols, Mar;11(3):399-412.
Deidda G, Parrini M, Naskar S, Fernandez I, Contestabile A, Cancedda L (2015). Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down Syndrome. Nature Medicine, 21(4):318-26.
Deidda G, Allegra M, Cerri C, Naskar S, Bony G, Zunino G, Bozzi Y, Caleo M, Cancedda L (2015). Early depolarizing GABA controls critical-period plasticity in the rat visual cortex. Nature Neuroscience, Jan;18(1):87-96.
Perlini L E, Szczurkowska J, Ballif B A, Sacchetti S, Piccini A, Giovedì S, Benfenati F, Cancedda L (2015). Synapsin III Acts Downstream of Semaphorin 3A/CDK5 Signaling to Regulate Radial Migration and Orientation of Pyramidal Neurons in Vivo. Cell Reports, in press.
Bony G, Szczurkowska J, Tamagno I, Shelly M, Contestabile A, Cancedda L (2013). Non hyperpolarizing GABAB receptor activation regulates neuronal migration and neurite growth and specification by cAMP/LKB1. Nature Communications, 4:1800.
Dal Maschio M, Ghezzi D, Bony G, Alabastri A, Deidda G, Brondi M, Sulis Sato S, Proietti Zaccaria R, Di Fabrizio E, Ratto GM, Cancedda L (2012). High-performance and Site-directed in Utero Electroporation by a Triple-electrode Probe. Nature Communications, 3:960.
Modulators of intracellular chloride concentration for treating Down syndrome. Provisional: US 61/919,195, 2013. Patent application: WO 2015/091857A1, 2015. Patent issued: US 9,822,368, 2017 (expiring in 2035). Inventors: Cancedda L, Contestabile A, Ben-Ari Y.
Electroporation device, Patent application: TO2011A000411, WO2012153291, 2012. Inventors: Cancedda L, Ratto GM . License agreement with BEX, Co, LTD (Japan) for commercialization of the device. The device is currently on the market (BEX, cat. number LF653).
Methods and pharmaceutical composition for deducing the expression of NKCC1 in a subject of need thereof. Inventors: Mingozzi F, Ronzitti G, Cancedda L, Contestabile A. Patent application: EU17 305 434.7, 2017 .
2017 Selected among the best 100 young Italian scientists operating in Italy or abroad (Cartaditalia magazine)
2016 Awarded the European Research Council (ERC) consolidator grant.
Appointed scholar of the FENS-KAVLI networkof excellence
Young researcher award, memorial Mario Mai
2015 Appointed assistant scientist at the Dulbecco Telethon Institute, Italy
2014 TRADECOM society adopted Telethon Project on Rett syndrome for communication to the lay public.
2013 Mention of honor, poster award, Convention Telethon, Italy.
Finalist at the scientific picture award “Beyond science”, Genova, Italy.
2011 Best poster award, Molecular Mechanisms in Neuroscience meeting, Rome, Italy.
2009 Young investigator award, Italian Society of Physiology (SIF), Italy.
2008 Best speaker award, Italian Society for Neuroscience (SINS), Milan, Italy.
2003 Ph.D. earned with Honors, Scuola Normale Superiore, Pisa, Italy.
2001 Travel award for participation to summer course “Structure, Function and Development of the Visual System”, Cold Spring Harbor Laboratory (CSHL), U.S.A.
1999 Graduation with Honors and Distinction in Major, University of Genoa, Italy.
1997 Scholarship for extracurricular departmental activities, University of Genoa, Italy.
Various members of the laboratory have received awards and honors, including:
2018 Selected for flash talk presentation, EMBO Workshop: Microglia 2018. Heidelberg-Germany (Pinto B)
Full scholarship for attending Summer school in Brain Disorders Research, MRC Centre for Neuropsychiatric Genetics and Genomics. Cardiff, United Kingdom (Bolla M)
Chronobiology and sleep medicine summer school (NDCN SCNi) Oxford (Bolla M)
2017 Winner of the Excellent Paper in Neuroscience Award (EPNA, 2016, Deidda G)
Selected for the FENS and IBRO-PERC stipend for attending the course Neural Circuit and Development Plasticity Course, Netherlands (Bolla M).
Selected for oral presentation, Trisomy 21 Research Society (T21RS), Chicago United States (Contestabile A).
Full scholarship for attending OIST DevNeuroCourse, Japan (Bolla M).
Selected for nanosymposium presentation SFN meeting Washington, United States (Contestabile S).
2016 Travel grant 1st IN Ph.D. Student & Postdoc Meeting, Alicante, Spain (Cwetsch A).
Full scholarship for attending OIST DevNeuroCourse, Japan (Savardi A).
2015 Selected for oral presentation EMBO meeting on Cortical Development (Szczurkowska J).
Selected for oral presentation EMBO meeting on Cortical Development (Naskar S).
Travel award to the Neuronus meeting Krakow, Poland (Naskar S).
Selected for oral presentation, Neuronus meeting Krakow, Poland (Cwetsch A).
Full scholarship for attending OIST DevNeuroCourse, Japan (Szczurkowska J).
2014 Best Poster Award, FENS-SFN Summer School, Bertinoro, Italy (Szczurkowska J).
Full travel and lodging bursary, ISDN meeting, Montreal, Canada (Szczurkowska J).
Selected for oral presentation & best presentation Neuronus meeting, Krakow, Poland (Szczurkowska J).
Best oral presentation International Young Scientists Conference, Poland (Kopanska M).
Scholarship, Neurobiology Summer School, SISSA, Trieste, Italy (Naskar S).
Full scholarship for attending OIST DevNeuroCourse, Japan (Cwetsch A).
Winner of the Art of Neuroscience competition, FENS meeting (Deidda G).
Honorable Mention, Photomicrography Competition, Nikon (Dal Maschio M).
Second classified at the Arte o Scienza contest, Trieste (Deidda G).
Mention of honor, picture award, Olympus Bioscapes competition (Szczurkowska J).
2013 Best poster award, Neurizons meeting, Germany (Szczurkowska J).
Selected for oral presentation, best speaker award; ENCODS, Bordeaux, France (Szczurkowska J).
Selected for oral presentation; ENCODS; Bordeaux, France (Deidda G).
Mention of honor poster award, Telethon Convention, Italy (Szczurkowska J).
Winner of European Project Practice in the Erasmus Program fellowship (Kopanska M).
Third classified at the picture award IIT Photo contest (Deidda G).
Finalist of the Photocontest Arte o Scienza; Trieste, Italy; 2013 (Szczurkowska J).
2011 Best poster award at the Molecular Mechanisms in Neuroscience meeting, Rome, Italy (Deidda G).
Winner of European Project FP7 fellowship, Leonardo da Vinci Program (Szczurkowska J).
Selected for oral presentation, Young Researchers in Physiology meeting, Italy (Bony G).