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Andrea Barberis

Senior Researcher Tenured - Principal Investigator

Research Line

Synaptic Plasticity of Inhibitory Networks

Center

IIT Central Research Labs Genova

Contacts

Via Morego 30
+39 010 2896 517
Contact Me

About

Andrea Barberis graduated in Biology at the University of Genoa in 1996, studying the permeation of heavy metal ions in L-type calcium channels in cerebellar granule cells. From 1998 to 2002 he accomplished his PhD studies at the Department of Biophisics–SISSA International School for Advanced Studies- under the supervision of Enrico Cherubini studying the gating of recombinant and synaptic GABAA receptors. From 2002 to 2003 he collaborated with Enrico Cherubini (SISSA) and Jerzy Mozrzymas (University of Medicine, Poland) studying the variability of the synaptic quantal size in relation to the kinetics of the agonist release in the synaptic cleft in hippocampal cultured neurons. During his post-doc in the Stefano Vicini’s lab at Gergetown University (Washington DC, USA, 2003-2005) he studied the gating properties of different GABAA subtypes by analyzing their single channel behavior in equilibrium and non-equilibrium conditions and he investigated the developmental changes of the GABA transient in the synaptic cleft in cerebellar granule cells. He also partecipated to several projects including the study of the role of pre-synaptic glutamate receptors at GABAergic synapses in cerebellar granule cells and the tonic inhibition in GABA-alpha1 subunit deficient mice. From 2005 to 2007 he had a CNRS post-doc in the Christophe Mulle’s lab (Bordeaux, France) studying the gating properties of kainate receptors.    

Currently, he has a team leader position at Italian Institute of Technology (IIT). Barberis' lab focuses on the study of the GABAergic synapse at high spatial and temporal resolution. His research projects aim to understand the post-synaptc determinants of plasticity at inhibitory synapses. In Barberis’ group, standard electrophysiology is implemented by the use of diffraction limited UV laser uncaging and advanced imaging techniques including single particle tracking.

Andrea Barberis has solid background in neurophysiology and has keen interest in studying the behavior of ionotropic fast ligand gated receptor channels. He contributed optimizing ultra-fast perfusion systems and emphasizing the impact of non-equilibrium conditions activation of GABAA receptors in the GABAergic synaptic transmission.

Projects

 

1)       Postsynaptic mechanisms of inhibitory GABAergic synaptic plasticity 

 

2)       Short-range interplay between plasticity of glutamatergic and GABAergic dendritic synapses

 

3)       Role of synaptic adhesion proteins in autistic spectrum disordes

 

 

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.