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Matteo Marzi

Senior Post Doc
Technologist
Genomic Science
Address
Research center
About

I'm a biotechnologist who has trained in genomic science, with over 10 years of experience in non-coding RNA Biology. My main interest is in the role of ncRNAs in differentiation and in cancer and, more specifically, in their ability to modify the expression of genes, shaping cell fate. My scientific approach is characterized by the exploitation of genome-wide approaches, novel technologies and bioinformatics.

Education

Title: PhD in Molecular Medicine
Institute: Università di Milano, European School Of Molecular Medicine (SEMM)
Location: Milan
Country: Italy
From: 2007 To: 2010

Title: Laurea Magistrale in Biotecnologie Farmaceutiche
Institute: Università di Milano
Location: Milan
Country: Italy
From: 2000 To: 2006

Skills

ncRNA biology
- Detection and Manipulation of non coding RNAs by CRISPRi/a/KO, GAPMERs, shRNA, etc.

Single Cell/Molecule Sequencing
- sc-RNA-seq
- sc-ATAC-seq

CRISPR functional Screenings
- CROP-SEQ
- Cell Tracking

Cancer Biology
- Breast Cancer models
- Cancer stem cells
- 3D cell culture

Next Gen Seq
- small RNA-seq
- RNA-seq
- ATAC-seq

Top Publications
2018
Ghini F., Rubolino C., Climent M., Simeone I., Marzi M.J., Nicassio F.
Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation
Nature Communications, vol. 9, (no. 1)
2016
Marzi M.J., Ghini F., Cerruti B., De Pretis S., Bonetti P., Giacomelli C., Gorski M.M., Kress T., Pelizzola M., Muller H., Amati B., Nicassio F.
Degradation dynamics of micrornas revealed by a novel pulse-chase approach
Genome Research, vol. 26, (no. 4), pp. 554-565
2015
Montani F., Marzi M.J., Dezi F., Dama E., Carletti R.M., Bonizzi G., Bertolotti R., Bellomi M., Rampinelli C., Maisonneuve P., Spaggiari L., Veronesi G., Nicassio F., Di Fiore P.P., Bianchi F.
MiR-test: A blood test for lung cancer early detection
Journal of the National Cancer Institute, vol. 107, (no. 6)
2014
Muller H., Marzi M.J., Nicassio F.
IsomiRage: From functional classification to differential expression of miRNA isoforms
Frontiers in Bioengineering and Biotechnology, vol. 2, (no. SEP)
2012
Marzi M.J., Puggioni E.M.R., Dall'Olio V., Bucci G., Bernard L., Bianchi F., Crescenzi M., Di Fiore P.P., Nicassio F.
Differentiation-associated microRNAs antagonize the Rb-E2F pathway to restrict proliferation
Journal of Cell Biology, vol. 199, (no. 1), pp. 77-95