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Annalisa Savardi

Post Doctoral Researcher
Post Doc
Brain Development and Disease
Research center
About

Annalisa graduated in Medical Biotechnology (BSc) at the University of Milan (Italy) in July 2012 and in Neurobiology (MSc) at the University of Pavia (Italy) with a thesis on the role of the synapse protein SNAP-25 in neurological disorders, under the supervision of Professor Michela Matteoli (Humanitas Institute). After one year of fellowship, she started her PhD program in Neuroscience under the supervision of Dr. Laura Cancedda and Dr. Marco De Vivo at IIT. During these 3 years she focused on the discovery and characterization of a novel drug candidate, which resulted in ameliorating core symptoms in Down syndrome and autism models. She obtained her PhD in Neuroscience in February 2019 from University of Genoa (Italy). Then, she obtained a position of Post Doc at Fondazione Telethon, affiliated to the Brain Development & Disease lab at IIT, to plan and perform further preclinical analysis for the development of the  drug candidate toward advanced preclinical phases. 

Recently, she has been awarded by a Postdoctoral Fellowship from Jerome Lejeune Foundation to study epilepsy in Down syndrome, hosted by Brain Development & Disease lab at IIT.

Annalisa expertise include in vivo transfection of nucleic acids (in utero electroporation), in vitro and in vivo pharmacology, biochemistry and cell/molecular biology, rodent behavioral testing. In addition to her technical expertise, she has writing and editing experience.



Education

Title: Ph.D. in Neuroscience
Institute: Università degli Studi di Genova and Istituto Italiano di Tecnologia
Location: Genoa
Country: Italy
From: 2015 To: 2018

Title: MSc in Neurobiology
Institute: Università degli Studi di Pavia
Location: Pavia
Country: Italy
From: 2012 To: 2014

Title: BSc in Medical Biotechnology
Institute: Università degli Studi di Milano
Location: Milan
Country: Italy
From: 2009 To: 2012

Top Publications
2021
Borgogno M., Savardi A., Manigrasso J., Turci A., Portioli C., Ottonello G., Bertozzi S.M., Armirotti A., Contestabile A., Cancedda L., De Vivo M.
Design, Synthesis,In VitroandIn VivoCharacterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in down Syndrome
Journal of Medicinal Chemistry, vol. 64, (no. 14), pp. 10203-10229
2021
Savardi A., Borgogno M., De Vivo M., Cancedda L.
Pharmacological tools to target NKCC1 in brain disorders
Trends in Pharmacological Sciences
Review Journal
2020
Savardi A., Ziogas I., Bolla M., Cancedda L.
Chloride Transporters in Physiological Brain Development and Neurodevelopmental Disorders: the Case of the Down Syndrome.
Neuronal Chloride Transporters in Health and Disease
Book Chapter Book
2020
Savardi A., Borgogno M., Narducci R., La Sala G., Ortega J.A., Summa M., Armirotti A., Bertorelli R., Contestabile A., De Vivo M., Cancedda L.
Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders
Chem, vol. 6, (no. 8), pp. 2073-2096
Article Journal
2020
Pinto B., Morelli G., Rastogi M., Savardi A., Fumagalli A., Petretto A., Bartolucci M., Varea E., Catelani T., Contestabile A., Perlini L.E., Cancedda L.
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome
Neuron, vol. 108, (no. 5), pp. 887-904.e12