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Stefania Mamberti

Marie Skłodowska-Curie MINDED Researcher
Nanotechnology for Precision Medicine
Research center

Stefania Mamberti is a Marie Skłodowska-Curie MINDED Researcher in the Laboratory of Nanotechnology for Precision Medicine headed by Prof. Dr. Paolo Decuzzi at the Italian Institute of Technology in Genoa, Italy, since October 2022. Within the MultIscale precision therapies for NeuroDEvelopmental Disorders - MINDED project, she will characterize the neuronal internalization and the axonal transport of nanoparticles to optimize the drug delivery of therapeutics for the treatment of neurodevelopmental disorders.

Stefania Mamberti achieved both her Bachelor Degree in Biological Sciences (2013) and her Master Degree in Molecular Biology and Genetics (2015) at the University of Pavia, Italy. It was during the practical internships as an Erasmus student at the Ruprecht-Karls-Universität Heidelberg, Germany, that her passion towards understanding life at a molecular level unveiled. Back to Pavia, she applied this interest to the functional identification and characterization of a novel γ-PGA hydrolase gene of phage origin in Bacillus subtilis (Mamberti et al., 2015), as the main subject of her Master thesis in the Laboratory of Microbial Genetics directed by Prof. Dr. Cinzia Calvio. In 2016, she succeeded in the professional practice examination, which qualified her to enroll in the Italian National Order of Biologists (ONB).

In 2017, she received a research scholarship funded by the Fondazione Bussolera Branca to work in the Laboratory of Microbial Biotechnologies directed by Prof. Dr. Alessandra M. Albertini at the University of Pavia, Italy. Upon a screening of soil samples for new larvicidal activities of bacterial origin against the tiger mosquito Aedes albopictus, she isolated and identified a novel Brevibacillus laterosporus strain with such property as a powerful biological tool to prevent the related vector-borne diseases (Barbieri et al., 2021).

In the same year, she joined the Cellular Biology and Epigenetics group of Prof. Dr. M. Cristina Cardoso at the Technische Universität Darmstadt, Germany, to pursue her doctoral studies within the context of the interdisciplinary Graduate College GRK 1657 - Molecular and Cellular Responses to Ionising Radiation (funded by the Deutsche Forschungsgemeinschaft - DFG). In 2022, she successfully defended her PhD thesis on the interplay between chromatin architecture, DNA replication and repair: structure versus function. In particular, she investigated the interrelationship between global genomic functions and the underlying chromatin structural units in mammalian cells (Mamberti and Cardoso, 2020), through the depletion of the two main chromatin architectural proteins cohesin (Cremer, Brandstetter et al., 2020) and CTCF (Mamberti et al., 2022).

All Publications
Mamberti S., Pabba M.K., Rapp A., Cristina Cardoso M., Scholz M.
The Chromatin Architectural Protein CTCF Is Critical for Cell Survival upon Irradiation-Induced DNA Damage
International Journal of Molecular Sciences, vol. 23, (no. 7)
Barbieri G., Ferrari C., Mamberti S., Gabrieli P., Castelli M., Sassera D., Ursino E., Scoffone V.C., Radaelli G., Clementi E., Sacchi L., Ferrari E., Gasperi G., Albertini A.M.
Identification of a Novel Brevibacillus laterosporus Strain With Insecticidal Activity Against Aedes albopictus Larvae
Frontiers in Microbiology, vol. 12
Mamberti S., Cardoso M.C.
Are the processes of DNA replication and DNA repair reading a common structural chromatin unit?
Nucleus, vol. 11, (no. 1), pp. 66-82
Cremer M., Brandstetter K., Maiser A., Rao S.S.P., Schmid V.J., Guirao-Ortiz M., Mitra N., Mamberti S., Klein K.N., Gilbert D.M., Leonhardt H., Cardoso M.C., Aiden E.L., Harz H., Cremer T.
Cohesin depleted cells rebuild functional nuclear compartments after endomitosis
Nature Communications, vol. 11, (no. 1)
Article Journal
Mamberti S., Prati P., Cremaschi P., Seppi C., Morelli C.F., Galizzi A., Fabbi M., Calvio C.
γ-PGA hydrolases of phage origin in bacillus subtilis and other microbial genomes
PLoS ONE, vol. 10, (no. 7)