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Stefania Sabella

Technologist

Research Line

D3 PharmaChemistry

Center

IIT Central Research Labs Genova

Contacts

Via Morego
+39 010 2896 289
Contact Me

About

Dr. Stefania Sabella is Researcher at the Istituto Italiano di Tecnologia in Genova. She holds a PhD in Medicinal Chemistry and a multidisciplinary background spanning from nanotechnology, to nanotoxicology, analytical chemistry, medicinal chemistry, and biochemistry. Author of about 40 papers, 5 patents, 2 book chapters, she is Task Leader in NanoREG1_ Framework 7 research project, WP leader in ITS-NANO_ Framework 7 research project, P.I. for IIT in NanoREG2_H2020, IIT member of GRAPHENE_FP7-ICT-FET Flagship. S.S is Committee member of ISO/TC 229/JWG2 and CEN/TC 352/WG 1/PG 2. She is also author of several contributions (invited and oral) to international conferences.

Main Research interests

In particular, her current works focus on:

-       Molecular mechanisms governing NP-cell interactions;

-       NP grouping  by physical-chemical properties/mode of actions;

-       Standardized analytical protocols/methods to characterize NP fate in biofluids relevant for human exposure and for nanoregulatory;

-       Bio-nano-material design with theranostic properties based on biomimicry of natural biological transporters (BSA NPs).

Career history

- 2015-current Researcher at Italian Institute of Technology, Genova, Italy

- 2009-15 Team Leader at Italian Institute of Technology, IIT-CBN@UniLe>

- 2008-9 Associate researcher at National Nanotechnology Laboratory-CNR

- 2006-8 Post-doctoral fellows at National Nanotechnology Laboratory-CNR, Lecce, Italy with Prof. R. Cingolani.

Development of smart polymeric microchips for efficient sensing of biomolecules and POC diagnostics.

- 2004 External researcher at TU-Wien, Austria with Prof. B. Lendl.

Hyphenation of FTIR and microcapillary systems for the separation and detection of amyloidogenic proteins such as abeta amyloids and beta-2-microglobulin.

- 2002-3 Junior researcher, University of Pavia (Department of Experimental and Applied Pharmacology), Italy.

Characterization of the Abeta amyloid fragments and their role in Alzheimer disease.

Education

- 2005-Ph.D. in Pharmaceutical Chemistry, University of Pavia, Italy.

Effect of drugs on the aggregation process of amyloidogenic proteins.

- 2002-M.Sc. in Analytical Chemistry at University of Pavia, Italy.

Development of analytical techniques to characterize amyloidogenic intermediates of β2-microglobulin and 1-40 and 1-42 Abeta-peptides.

Projects

- IIT Unit Coordinator of NANOTEG2_H2O2O

- IIT Unit Coordinator of “Translating innovation into colorectal cancer control” AIRC 2010-2012;

- Task Leader NANOREG_ Framework 7 research project

- WP Leader of ITS-NANO_ Framework 7 research project

- Participant to NanoMax, Flagship Italian Project “Development of a miniaturized paltform for multiparametric diagnostics”.

- Participant to ITEM, Programma Operativo Nazionale Ricerca E Competitivita’ 2007-2013 Per Le Regioni Dell'obiettivo Convergenza;

- WP leader of FIRB Nanogenomica (2007-2013).

- Selected as Italian researcher in the Bilateral and Multilateral Cooperation project “Technological Innovation and Transfer of Technology” financially supported by the Ministry of Foreign Affair (Italy) and TU-Wien (Austria). Name of the project: “New instrumental techniques for the characterization of early folding intermediates of β2-microglobulin and other proteins responsible for amyloidosis”.

Teaching and tutoring activities

Tutoring activities of  graduate and PhD students (University of Pavia, University of Lecce and IIT) on multidisciplinary activities in Physics, Biology, Biotechnology, Medicinal Chemistry.

Professional Services

- Stefania Sabella served as expert and project reviewer for the Croatian Science Foundation.

- Stefania Sabella is reviewer of several international journals.

- Stefania Sabella is IIT representative to the EU NanoSafety Cluster.

Selected Publications

Publications

  1. Dissolution test for risk assessment of nanoparticles: a pilot study” Pasquale Bove, Maria Ada Malvindi, Sachin Sayaji Kote, Rosalia Bertorelli, Maria Summa and Stefania Sabella , Nanoscale, 2017, Advance Article DOI: 10.1039/C6NR08131B

  2. V. Stone, S. Pozzi-Mucelli, L. Tran, K. Aschberger, S. Sabella, U. Vogel, C. Poland, D. Balharry, T. Fernandes, S. Gottardo, S. Hankin, M. G.J. Hartl, N. Hartmann, D. Hristozov, K.Hund-Rinke, H. Johnston, A. Marcomini, O Panzer, D. Roncato, A. T Saber, H. Wallin and J.J Scott-Fordsmand “A unified framework for nanosafety is needed”NanoToday (2014, accepted)

  3. D. Guarnieri*, S. Sabella*, O. Muscetti, V. Belli, M.A. Malvindi, S. Fusco, E. De Luca, P.P. Pompa, and P.A. Netti “Transport across cell-membrane dictates nanoparticle fate and toxicity: a new paradigm in nanotoxicology” Nanoscale (2014, in press). DOI: 10.1039/C4NR02008A. (* equally contributing authors)
  4. S Sabella, RP Carney, V Brunetti, MA Malvindi, N Al-Juffali, G Vecchio, S.M. Janes, O. M. Bakr, R. Cingolani, F. Stellacci, P.P. Pompa “A general mechanism for intracellular toxicity of metal-containing nanoparticles,” Nanoscale 6 (12), 7052-7061, (2014).
  5. S. Corvaglia, B. Sanavio, R.P.H. Enriquez, B. Sorce, A. Bosco, D. Scaini, S. Sabella, G. Scoles, P.P. Pompa, and L. Casalis “Atomic force microscopy based nanoassay: a new method to study α-Synuclein-dopamine bioaffinity interactions” Scientific Reports 4, 5366 (2014). DOI:10.1038/srep05366
  6. V. Stone, S. Pozzi-Mucelli, L. Tran, K. Aschberger, S. Sabella, U. Vogel, C. Poland, D. Balharry, T. Fernandes, S. Gottardo, S. Hankin, M. G.J. Hartl, N. Hartmann, D. Hristozov, K.Hund-Rinke, H. Johnston, A. Marcomini, O Panzer, D. Roncato, A. T Saber, H. Wallin and J.J Scott-Fordsmand “ITS-NANO - Prioritising nanosafety research to develop a stakeholder driven intelligent testing strategy”, Particle and fibre toxicology 11 (1), 9, (2014). DOI:10.1186/1743-8977-11-9
  7. Rizzello L, Galeone A, Vecchio G, Brunetti V, Sabella S, Pompa PP “Molecular response of Escherichia coli adhering onto nanoscale topography” Nanoscale Res Lett. Oct 18;7(1):575, (2012).
  8. Vecchio G, Galeone A, Brunetti V, Maiorano G, Sabella S, R. Cingolani, and P.P. Pompa  (2012) Concentration-Dependent, Size-Independent Toxicity of Citrate Capped AuNPs in Drosophila melanogaster. PLoS ONE 7(1): e29980. doi:10.1371/journal.pone.0029980.
  9. G. Vecchio, A. Galeone, V. Brunetti, G. Maiorano, L. Rizzello, S. Sabella, R. Cingolani, and P.P. Pompa “Mutagenic effects of gold nanoparticles induce aberrant phenotypes in Drosophila melanogaster” Nanomedicine : nanotechnology, biology, and medicine 8, 1-7 (2012). DOI: 10.1016/j.nano.2011.11.001) Cover Article
  10. L. Rizzello, G. Vecchio, V. Brunetti, G. Maiorano, M.A. Malvindi, A. Galeone, S. Sabella, P.P. Pompa “Impact of nanomaterials on in vitro and in vivo systems: role of nanoscale features in nanotoxicology” Proceedings of SPIE 8232, 82320E (2012).
  11. S. Sabella, G. Maiorano, L. Rizzello, S. Kote, R. Cingolani, P.P. Pompa “Framing the nano-biointeractions by proteomics” Proceedings of SPIE 8232, 82320S (2012).
  12. S. Sabella, V. Brunetti, G. Vecchio, A. Galeone, G. Maiorano, R. Cingolani, and P.P. Pompa “Toxicity of citrate-capped AuNPs: an in vitro and in vivo assessment.” J. Nanopart. Res. 13, 6821-6835, (2011). DOI:10.1007/s11051-011-0590-x
  13. P.P. Pompa, G. Vecchio, A. Galeone, V. Brunetti, G. Maiorano, S. Sabella, and R. Cingolani “Physical assessment of toxicology at nanoscale: nano dose-metrics and toxicity factor” Nanoscale 3, 2889-97 (2011).
  14. S. Sabella, A. Galeone, G. Vecchio, R. Cingolani, and P.P. Pompa “AuNPs are toxic in vitro and in vivo: a review” J. Nanosci. Lett. 1, 145-165 (2011).
  15. L. Rizzello, B. Sorce, S. Sabella, G. Vecchio, A. Galeone, V. Brunetti, R. Cingolani, and P.P. Pompa “Impact of nanoscale topography on genomics and proteomics of adherent bacteria” ACS Nano 5, 1865-76 (2011).
  16. B. Sanavio, S. Corvaglia, B. Sorce, S. Sabella, P.P. Pompa, G. Scoles, L. Casalis, “Controlled immobilization and nanoscale supramolecular assembly of intrinsically disordered proteins” Eur. Biophys. J. Biophys. Lett. 40 (S1), 57-58 (2011).
  17. I. S. Bayer, D. Fragouli, A. Attanasio, B. Sorce, G. Bertoni, R. Brescia, R. Di Corato, T. Pellegrino, M. Kalyva, S. Sabella, P. P. Pompa, R. Cingolani, and A. Athanassiou, "Water-Repellent Cellulose Fiber Networks with Multifunctional Properties," ACS Applied Materials & Interfaces, vol. 3, pp. 4024-4031, 2011.
  18. P.P. Pompa, G. Vecchio, A. Galeone, V. Brunetti, G. Maiorano, S. Sabella, and R. Cingolani “Physical assessment of toxicology at nanoscale: nano dose-metrics and toxicity factor” Nanoscale 3, 2889-97 (2011).
  19. P.P. Pompa, G. Vecchio, A. Galeone, V. Brunetti, S. Sabella, G. Maiorano, A. Falqui, G. Bertoni, and R. Cingolani “In vivo toxicity assessment of gold nanoparticles in Drosophila melanogaster Nano Research (2011) 4, 405-413 DOI 10.1007/s12274-011-0095-
  20. S. Sabella, G. Maiorano, B. Sorcie, V. Brunetti, M. A. Malvindi, R. Cingolani and P. P. Pompa, “Cell Culture Media Elicit a Different Dynamic Formation of Protein-NP Complexes: Effects on the Cellular Response” Conference Technical Proceedings, Nanotech (2011), Vol 3, Chapter 7, Environment, Health & Safety, Pages 517 - 520.
  21. G. Vecchio, A. Galeone, V. Brunetti, G. Maiorano, M. A. Malvindi, S. Sabella, R. Cingolani, and P.P. Pompa, “In vivo nanotoxicity assessment: the role of size, surface coating, nanostructuration, and dose-metrics” TechConnectWorldConference and Expo 2011, June 13-16, Boston (MA), Conference Technical Proceedings, Nanotech (2011), Vol 3, Chapter 7, Environment, Health & Safety, Pages 509 – 512.
  22. S. Sabella, V. Brunetti, G. Maiorano, L. Rizzello, B. Sorcie, G. Vecchio, A. Galeone, R. Cingolani, P.P. Pompa “Nanomaterials Can Influence Living Biological Systems with Nanometer Sensitivity” “Conference Technical Proceedings, Nanotech (2011), Vol 3, Chapter 3, Bio Nano Materials, Pages 167-170.
  23. G. Maiorano, S. Sabella*, B. Sorcie, V. Brunetti, M.A. Malvindi, R. Cingolani, and P.P. Pompa “Effects of Cell Culture Media on the Dynamic Formation of Protein-NP Complexes and Influence on the Cellular Response” *Corresponding author,ACS Nano, 4(12), 7481–7491 (2010).
  24. S. Sabella, G. Vecchio, V. Brunetti, R. Cingolani, R. Rinaldi, and P.P. Pompa “Direct PCR analyses of real biological samples in a plastic microreactor” J. Anal. Chem. 66, 528-534 (2011).
  25. V. Brunetti, G. Maiorano, L. Rizzello, B. Sorcie, S. Sabella, R. Cingolani and P. P. Pompa “Neurons sense nanoscale roughness with nanometer sensitivity”, Proc. Natl. Acad. Sci. USA, 107(14) (2010) 6264-6269.
  26. L. Martiradonna, F. Pisanello, T. Stomeo, A. Qualtieri, G. Vecchio, S. Sabella, R. Cingolani, M. De Vittorio, P. P. Pompa “Spectral tagging by integrated photonic crystal resonators for highly sensitive and parallel detection in biochips” APL, 96, (2010), 113702.
  27. F. Pisanello, L. Martiradonna, P.P. Pompa, T. Stomeo, A. Qualtieri, G. Vecchio, S. Sabella, and M. De Vittorio “Parallel and high sensitive photonic crystal cavity assisted readout for DNA-chips” Microelectronics Engineering, 87 (2010) 5, 747.
  28. S. Sabella, S. Shiv Shankar, G. Vecchio, V. Brunetti, L. Rizzello, A. Qualtieri, L. Martiradonna, R. Cingolani, and P.P. Pompa “Room-temperature metal stamping by microfluidics”, Materials Letters 64 (2010) 41–44
  29. G. Vecchio*, S. Sabella*, L. Tagliaferro, P. Menegazzi, M.P. Di Bello, V. Brunetti, R.Rinaldi, R. Cingolani and P.P. Pompa “Modular plastic chip for a one shot HPV diagnostic analysis” Analytical Biochemistry 397 (2010) 53–59 (* equally contributing authors).
  30. S. Sabella, G. Vecchio, P.P. Pompa, G. Maruccio, L. Sanarica, A. Della Torre, G. De Bellis, G. Caramenti, C. Consolandi, M. Severgnini, R. Cingolani and R. Rinaldi, “Disposable plastic microreactors for genomic analyses”, Biomed Microdevices (2009) 11:1289–1295
  31. S. Sabella, V. Brunetti, G. Vecchio, R. Rinaldi, R. Cingolani, and P.P. Pompa, “Nanoscale parallel patterning of functional biomolecules, organic fluorophores and colloidal nanocrystals” Nanoscale Res Lett (2009) 4:1222–1229.
  32. B. Sorce*, S. Sabella*, M. Sandal, B. Samorì, A. Santino, R. Cingolani, R. Rinaldi, and P.P. Pompa “Single molecule mechanical unfolding of amyloidogenic β2-microglobulin: Force-Spectroscopy approach”, ChemPhysChem  2009, 10, 1471 – 1477 (* equally contributing authors).
  33. S. Sabella, G. Vecchio, R. Cingolani, R. Rinaldi, and P. P. Pompa, “Real-Time PCR in a Plastic Chip Based on Solid State FRET”, Langmuir 2008, 24, 13266-13269.
  34. E. De Lorenzi, R. Colombo, S. Sabella, D.B. Corlin, and N.H.H. Heegaard The influence of Cu2+ on the unfolding and refolding of intact and proteolytically processed β_2-microglobulin” Electrophoresis, 2008, 29, 1734–1740.
  35. L.L. del Mercato,P.P. Pompa, G. Maruccio, A. Della Torre, S. Sabella, A.M. Tamburro, R. Cingolani, and R. Rinaldi “Charge transport and intrinsic fluorescence in amyloid-like fibrils” Proc. Natl. Acad. Sci. USA, 2007, 104, 46, 18019-18024.
  36. Quaglia, M. Carazzone C., Sabella, S., Colombo R., Giorgetti, S., Bellotti, V., De Lorenzi, E. “Search of ligands for the amyloidogenic protein beta2microglobulin by capillary electrophoresis and other techniques” Electrophoresis, 2005 Nov;26(21):4055-63.
  37. Sabella, S.; Quaglia, M.; Lanni, C.; Racchi, M.; Govoni, S.; Caccialanza, G.; Calligaro, A.; Bellotti, V.; De Lorenzi, E. “Capillary electrophoresis studies on the aggregation process of β-amiloid Aβ 1-42 and Aβ 1-40 peptides”Electrophoresis, 2004, 25, 3186.

Chapters for International Book

1.      Sabella S. “Impact of Bionanointeractions of Engineered Nanoparticles for Nanomedicine”, Nanotoxicology: Progress toward Nanomedicine, CRC Press/Taylor &Francis Group LLCS, 2, 21-31, (2014).

2.      S Sabella, P P Pompa, B Sorce, L L del Mercato, R Rinaldi (2010) “Amyloid fibrils: from nature to nanotechnology” Research Signpost isbn:978-81-308-0425-5.

Patents

1.      P.P. Pompa, S. Sabella, R. Cingolani “Device And Method For Determining The Dissolution Kinetics Of Colloidal Nanoparticles” PCT/IB2013/056645 (2013) (Patent TO2012A000730).

2.      Athanassiou, I.S. Bayer, I. Liakos, L. Rizzello, R. Cingolani, S. Sabella, P.P. Pompa “Materiali compositi polimerici con proprietà antimicrobiche e biodegradabili e loro usi” Patent TO2012A000258 (2012).

3.      S. Sabella, P.P. Pompa, G. Maruccio, G. Vecchio, R. Cingolani, and R. Rinaldi “Microdispositivo integrato per reazioni di amplificazione di acidi nucleici (Integrated plastic microdevice for quantitative analyses of real-time PCR)” Patent TO2008A000810 (2008).

4.      K. Aoki, M. De Vittorio, T. Stomeo, F. Pisanello, A. Massaro, L. Martiradonna, S. Sabella, R. Rinaldi, Y. Arakawa, R. Cingolani, and P.P. Pompa “Procedimento per la rivelazione di un analita, con l’impiego di cristalli fotonici risonanti e relativo dispositivo” Patent TO2008A000614 (2008)

5.      P.P. Pompa, S. Sabella, R. Rinaldi, R. Cingolani, and F. Calabi “A method and a microdevice for the identification and/or quantification of an analyte in a biological sample with optical detection systems based on FRET processes” PCT Int. Appl. (2008) - WO  2008072209.

Proceedings at International Conferences

1.        L. Rizzello, G. Vecchio, V. Brunetti, G. Maiorano, M.A. Malvindi, A. Galeone, S. Sabella, P.P. Pompa “Impact of nanomaterials on in vitro and in vivo systems: role of nanoscale features in nanotoxicology” Proceedings of SPIE 8232, 82320E (2012).

2.        S. Sabella, G. Maiorano, L. Rizzello, S. Kote, R. Cingolani, P.P. Pompa “Framing the nano-biointeractions by proteomics” Proceedings of SPIE 8232, 82320S (2012).

3.        S. Sabella, G. Maiorano, B. Sorce, V. Brunetti, M. A. Malvindi, R. Cingolani and P. P. Pompa “Cell Culture Media Elicit a Different Dynamic Formation of Protein-NP Complexes: Effects on the Cellular Response”, Conference Technical Proceedings, Nanotech 2011, Vol 3, Chapter 7, Environment, Health & Safety, Pages 517 - 520.

4.        G. Vecchio, A. Galeone, V. Brunetti, G. Maiorano, M. A. Malvindi, S. Sabella, R. Cingolani, and P.P. Pompa “In vivo nanotoxicity assessment: the role of size, surface coating, nanostructuration, and dose-metrics”, TechConnectWorldConference and Expo 2011, June 13-16, Boston (MA), Conference Technical Proceedings, Nanotech 2011, Vol 3, Chapter 7, Environment, Health & Safety, Pages 509 - 512.

5.        Sabella, V. Brunetti, G. Maiorano, L. Rizzello, B. Sorce, G. Vecchio, A. Galeone, R. Cingolani, P.P. Pompa “Nanomaterials Can Influence Living Biological Systems with Nanometer Sensitivity” Conference Technical Proceedings, Nanotech 2011, Vol 3, Chapter 3, Bio Nano Materials, Pages 167-170.

Selected oral contributions to international conferences

1.        S. Sabella “Framing the nano-biointeractions by proteomics” Bios SPIE Photonics West, 21 - 26 January 2012, Moscone Center, San Francisco, CA, USA (Invited).

2.        S. Sabella, et al. “Cell Culture Media Elicit a Different Dynamic Formation of Protein-NP Complexes: Effects on the Cellular ResponseTechConnectWorldConference and Expo 2011, June 13-16, Boston (MA) (Oral Comunication).

3.        S. Sabella “Nano-biointeractions and nanotoxicology@IIT-CBN” 1st Italian-Swedish Workshop on Health Impacts of Engineered Nanoparticles, Tor Vergata University, Rome, October 14-15 (2010) (Invited).

4.        S. Sabella“Nanomaterials can influence living biological systems with nanometer sensitivity” BIT's 1st Annual World Congress of NanoMedicine, October 23-25, 2010, Beijing, China (Invited).

5.        S. Sabella “Nano-biointeractions and nanotoxicology@IIT-CBN” Nanomedicine @ King’s College London (KCL), 1th Symposium of Nanomedicine, 01 December 2010, London, UK (Invited).

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