Federica Marinaro graduated in Medical Biotechnology at the University of Naples “Federico II”, Italy, in 2011.
From Oct. 2008 to Dec. 2009 she was undergraduate student in the laboratory of Prof. G. Paolella, where she studied cell migration with time-lapse imaging. During her master’s degree, from Mar. 2010 to Oct. 2011, she was student in the laboratory of Prof. Zollo at CeInGe institute of Naples, where she tested novel lipid carriers for miRNA delivery in vitro/vivo (e.g., in mouse medulloblastoma), isolated novel biomarkers in circulating tumor cells from plasma of oncologic patients and investigated the functions of the protein H-Prune in tumors.
From Jan. 2012 to Apr. 2015 she was a PhD student in the laboratory of Dr. De Pietri Tonelli at Neuroscience and Brain Technologies dept. at the Italian Institute of Technology (IIT) of Genova, where she received her PhD degree in Neurobiology of microRNA.
Federica is currently investigating the microRNA-dependent and independent roles of DGCR8 protein in embryonic mouse neurogenesis, studying its involvement in the neurodevelopmental origin of the 22q11.2 microdeletion syndrome (or DiGeorge syndrome).
Neurogenesis is defined as the process of generation of new neurons from the differentiation of neural stem (or progenitors) cells. In mammals, most of the neurons are generated from neural progenitors during embryonic development. In the recent years, microRNAs (miRNAs) have rapidly emerged as a new layer of regulation of brain development, function and dysfunction. MiRNAs are a class of short (~ 22-nt), non-coding RNAs, that control gene expression at the post-transcriptional level, mostly by imperfect base-pairing with specific mRNA targets. We are currently investigating the role of miRNAs in embryonic neurogenesis in mouse models of human neurodevelopmental disorders.
Andolfo I., Liguori L., De Antonellis P., Cusanelli E., Marinaro F., Pistollato F., Garzia L., De Vita G., Petrosino G., Accordi B., Migliorati R., Basso G., Cinalli G., Achille Iolascon, and Massimo Zollo. The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15 and epigenetic modifications in medulloblastoma. Neuro oncology, January 2012.
Clovis Y.M., Enard W., Marinaro F., Huttner W.B., De Pietri Tonelli D. Convergent repression of Foxp2 3'UTR by miR-9 and miR-132 in embryonic mouse neocortex: implications for radial migration of neurons. Development, September 2012.
de Antonellis P, Liguori L, Falanga A, Carotenuto M, Ferrucci V, Andolfo I, Marinaro F, Scognamiglio I, Virgilio A, De Rosa G, Galeone A, Galdiero S, Zollo M. MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines. Naunyn Schmiedebergs Arch Pharmacol., January 2013
Poster, "mRNA FATE - life and death of the mRNA in the cytoplasm" Workshop - May 2012, Lake of Garda, Italy.