Fanny Jaudon obtained a Master degree in Neuroscience at the University of Montpellier, France in 2008. She then joined the laboratory of Anne Debant at the Cell Biology Research Center of Montpellier for her PhD, investigating the importance of Rho GTPases and their activators, Rho GEFs in dendritogenesis and spine formation.
She joined the Italian Institute of Technology (IIT) as a postdoctoral researcher in June 2014, first working with Dr Fabrizia Cesca on the molecular mechanisms regulating neuronal excitability and formation of functional brain circuits, through the characterization of the role of the scaffold protein Kidins220 in the mature neurons and in astrocytes.
Since November 2016 she is working in the group of Dr Lorenzo Cingolani on the role of integrins in cortical circuits function and investigating their potential as molecular target for the development of autism spectrum disorders (ASD) therapies using genome-editing approaches.
Genome-editing approaches for personalized medicine in inherited diseases
This project aims to developing novel strategies for personalized medicine in inherited brain diseases with a complex and multifactorial genetic architecture. To this end, I am developing a CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9)-based strategy to modulate integrin expression in neurons to rescue behavioral and synaptic deficits in a mouse model of ASDs.