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Emilio Parisini

Researcher

Research Line

Nanomaterials for Energy and Lifescience

Center

CNST@PoliMi Milano

Contacts

Via G. Pascoli 70/3, 20133 Milano (Italy)
+39 022 3999 870
+39-02-23999870
Contact Me

About

I am a Group Leader at the Center for Nano Science and Technology of the Istituto Italiano di Tecnologia (IIT) in Milano (Italy). I received a Master of Science degree in Chemistry cum laude from the University of Bologna (Italy) in 1990. In 1995, I received a Ph.D. in Chemistry from the same institution. I subsequently carried out post-doctoral research at the Universities of Göttingen (Germany, 1995-1997), Cambridge (U.K., 1997-2001) and Harvard (U.S.A., 2001-2009). In 2008, I obtained a Master of Science degree in Epidemiology from Harvard University. I am the recipient of a Marie Curie International Reintegration Grant (IRG) [“Destabilization of Epithelial Tissue Architecture by Competition with E-cadherin Homo-dimer formation: small molecule-induced disruption of epithelium integrity and functions: a structural study"] (FP7-PEOPLE-2010-RG; 2010-2014) from the European Union. So far, I have published over 90 papers in peer-reviewed international journals (h-index: 30, source: ISIWEB OF KNOWLEDGE) and I am the co-author of two book chapters on solid state chemistry and structure-based drug design. In January 2010, I became a Team Leader at the newly established Center for Nano Science and Technology (CNST) of the IIT in Milano. 

I am currently leading a research group of 4 people (3 PhD students and one senior post-doc).

Projects

In our laboratory, we focus on the study of the structure-function relationship in both chemical and biological systems. We use single crystal X-ray crystallography for the structural characterization of large proteins as well as small organic and organometallic molecules for a variety of biomedical and technological applications.

From a biological standpoint, our current research interests are focused primarily on the study of the interactions between proteins and their ligands, substrates or inhibitors. In particular, we study members of a large family of calcium-dependent cell-cell adhesion proteins called cadherins, which mediate cellular adherens junction formation and tissue morphogenesis. We also study a number of enzymes that are implicated in a diverse set of pathological conditions ranging from diabetes to Alzheimer disease and cancer.

As solid state chemists, we also focus on the structural characterization of small synthetic molecules for optical (polythiophenes, diarylethenes) as well as biomedical (drug design, bio-imaging) applications. The study of the molecular structure of these novel compounds and the analysis of their packing interaction in the solid state by means of X-ray crystallography provides important insights into the macroscopic properties of these materials as well as their possible applications.

Our expertise include: molecular biology techniques (PCR, DNA cloning), protein expression (bacteria, insect cells, mammalian cells), protein purification, crystallization techniques, the use of in-house X-ray diffractometers as well as synchrotron beam lines for single crystal X-ray diffraction data collection, small molecule and protein structure solution and refinement, sequence analysis and molecular modeling, supra-molecular chemistry, structure-based drug design and the use of statistical software (SAS, Stata) for the analysis of large databases for clinical and epidemiological applications.

Our chemistry, biochemistry and X-ray crystallography laboratories are fully endowed with state-of-the-art equipment for gene amplification and cloning, protein expression and purification, protein crystallization and single crystal X-ray diffraction analysis. 

Selected Publications

 

      Book Chapters

2.         Blundell TL, Abell C, Cleasby A, Hartshorn MJ, Tickle IJ, Parisini E, Jhoti H   High-throughput X-ray crystallography for drug discovery.  In: “Drug Design: Cutting edge approaches” (2002), Royal Society of Chemistry, Darren R. Flower editor, ISBN 0-85404-816-2

1.         Braga D, Grepioni F, Parisini E, Sabatino P.  From molecule to molecular aggregation in solid organometallic materials.  In: “Syntheses and Metodologies in Inorganic Chemistry - New Compounds and Materials”, (Ed. Daolio S, Fabrizio M, Guerriero P, Tondello E, Vigato PA, Padova, 1993; Vol. 3:49-60).

 

      List of publications

92.      Leone G, Groppo E, Zanchin G, Martino G, Piovano A, Bertini F, Marti-Rujas J, Parisini E, Ricci G. Concerted Electron Transfer in Iminopyridine Chromium Complexes: Ligand Effects on the Polymerization of Various (Di)olefins. Organometallics, 2018, 37, 4827.

91.      Prosdocimi T, Mollica L, Donini S, Semrau MS, Lucarelli AP, Aiolfi E, Cavalli A, Storici P, Alfei S, Brullo C, Bruno O, Parisini E. Molecular bases of PDE4D inhibition by memory-enhancing GEBR-library compounds. Biochemistry, 2018, 57, 2876.

90.      Zanchin G, Pierro I, Parisini E, Martí-Rujas J, Ricci G, Leone G. Synthesis, Structure and Behavior of Vanadium(III) Diphosphine Complexes in the Homo- and Co-Polymerization of Ethylene with Norbornene: The Ligand Donor Strength and Bite Angle Make the Difference. J. Organomet. Chem., 2018, 861, 142.

89.       Pierro I, Zanchin G, Parisini E, Marti-Rujas J, Canetti M, Ricci G, Bertini F, Leone G. Chain-walking polymerization of α-olefins by α-diimine Ni(II) complexes: the effect of reducing the steric hindrance of ortho- and para- aryl substituents on the catalytic behavior, monomer enchainment and polymer properties. Macromolecules, 2018, 51, 801.

88.        Rigoldi F, Donini S, Giacomina F, Sorana F, Redaelli A, Bandiera T, Parisini E*, Gautieri A*. Thermal stabilization of the deglycating enzyme Amadoriase I by rational design. Sci. Rep. 2018, 8, 3042. (*co-corresponding author)

87.        Rigoldi F, Donini S, Redaelli A, Parisini E*, Gautieri A*. Engineering of Thermostable Enzymes for Industrial applications. APL Bioeng., 2018, 2, 011501. (*co-corresponding author)

86.       Rigoldi F, Spero L, Dalle Vedove A, Redaelli A, Parisini E, Gautieri A. Molecular dynamics simulations provide insights into the substrate specificity of FAOX family members. Mol. Biosyst., 2016, 12, 2622.

85.       Nardone V, Lucarelli AP, Dalle Vedove A, Fanelli R, Tomassetti A, Belvisi L, Civera M, Parisini E. Crystal structure of human E-cadherin-EC1EC2 in complex with a peptidomimetic competitive inhibitor of cadherin homophilic interaction. J. Med. Chem., 2016, 59, 5089.

84.         Castagna R, Nardone V, Pariani G, Parisini E, Bianco A. The interplay of soft-hard substituents in photochromic diarylethenes. J. Photochem. Photobiol. A, 2016, 325, 45.

83.       Tampieri F, Colella L, Maghsoumi A, Martí-Rujas J, Parisini E, Tommasini M, Bertarelli C, Barbon A. Meeting the challenging magnetic and electronic structure of thiophene-based heterophenoquinones. J. Phys. Chem. C, 2016, 120, 5732.

82.       Rigoldi F, Gautieri A, Dalle Vedove A, Lucarelli AP, Vesentini S, Parisini E. Crystal structure of the deglycating enzyme Amadoriase I in its free form and substrate-bound complex. Proteins, 2016, 84, 744.

81.       Mendola D, Saleh N, Hellou N, Vanthuyne N, Roussel C, Toupet L, Castiglione F, Melone F, Caronna T, Martí-Rujas J, Fontana F, Parisini E, Malpezzi L, Mele A, Crassous J. Synthesis and structural properties of Aza[n]helicene platinum complexes: control of cis and trans stereochemistry. Inorg. Chem., 2016, 55, 2009.

80.       Fanzani L, Porta F, Meneghetti F, Villa S, Gelain A, Lucarelli AP, Parisini E. Mycobacterium tuberculosis low molecular weight phosphatases (MPtpA and MPtpB): from biological insight to inhibitors. Curr. Med. Chem., 2015, 22, 3110.

79.       Bartelmess J, Baldrighi M, Nardone V, Parisini E, Buck D, Echegoyen L and Giordani S. Synthesis and characterization of far-red/NIR-fluorescent BODIPY dyes, solid-state fluorescence and application as fluorescent tags for carbon nano-onions. Chem. Eur. J., 2015, 21, 9727.

78.       Dalle Vedove A, Lucarelli AP, Nardone V, Matino A, Parisini E. The X-ray structure of human P-cadherin EC1-EC2 in a closed conformation provides insight into the type I cadherin dimerization pathway. Acta Crystallogr. Sect F, 2015, F71, 371.

77.       Colella L, Brambilla L, Nardone V, Parisini E, Castiglioni C, Bertarelli C. Outside rules inside: the role of electron-active substituents in thiophene-based heterophenoquinones. Phys. Chem. Chem. Phys., 2015, 17, 10426.

76.       Doro F, Colombo C, Alberti C, Arosio D, Belvisi L, Casagrande C, Fanelli R, Manzoni L, Parisini E,  Piarulli U, Luison E., Figini M., Tomassetti A, Civera M. Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions. Org. Biomol. Chem., 2015, 13, 2570.

75.       Pendolino F, Parisini E, Lo Russo S. Time-Dependent Structure and Solubilization Kinetics of Graphene Oxide in Methanol and Water Dispersions. J. Phys. Chem. C., 2014, 118, 28162.

74.       Bartelmess J, De Luca E, Signorelli A, Baldrighi M, Becce M, Brescia R, Nardone V, Parisini E, Echegoyen L, Pompa PP, Giordani S. Boron dipyrromethene (BODIPY) Functionalized Carbon Nano-Onions for High Resolution Cellular Imaging. Nanoscale 2014, 6, 1376.

73.       Panackal A, Parisini E, Proschan M. Salvage Combination Antifungal Therapy For Acute Invasive Aspergillosis May Improve Outcomes: A Systematic Review And Meta-Analysis. Int. J. Infect. Dis., 2014, 28, e80-e94.

72.      Nicolini T, Famulari A, Gatti T, Martí-Rujas J, Villafiorita-Monteleone F, Canesi EV, Meinardi F, Botta C, Parisini E, Meille SV, Bertarelli C. Structure-Photoluminescence Correlation for Two Crystalline Polymorphs of a Thiophene-Phenylene Co-Oligomer with Bulky Terminal Substituents. J. Phys. Chem. Lett., 2014, 5, 2171.

71.       Lee PY, Wang JX, Parisini E, Dascher CC, Nigrovic PA. Ly6 family proteins in neutrophil biology. J. Leukoc. Biol., 2013, 94, 585.

70.       Polito A, Parisini E, Ricci Z, Picardo S, Annane D. Vasopressin and terlipressin in adult vasodilatory shock. Crit. Care, 2012, 16, 470.

69.       Cortesi L, De Nicolo A, Medici V, Marino M, Turchetti D, Pradella LM, Rossi G, Parisini E, Federico M. Collective evidence supports neutrality of BRCA V1687I, a novel sequence variant in the conserved THV motif of the first BRCT repeat. Breast Cancer Res. Treat., 2012, 134, 435-441.

68.       Polito A, Parisini E, Ricci Z, Picardo S, Annane D. Vasopressin for treatment of vasodilatory shock: an ESICM systematic review and meta-analysis. Intensive Care Med., 2012, 38, 9-19.

67.       Parisini E, Metrangolo P, Pilati T, Resnati G, Terraneo G. Halogen bonding in halocarbon-protein complexes: a structural survey. Chem. Soc. Rev., 2011, 40, 2267-78.

66.       Dodwell ER*, Latorre JG*, Parisini E*, Zwettler E*, Chandra D, Mulpuri K, Snyder B. NSAID exposure and risk of nonunion: a meta-analysis of case-control and cohort studies. Calcif. Tissue Int., 2010, 87, 193-202. (* equal contribution)

65.       Platz E, Goldflam K, Mennicke M, Parisini E, Christ M, Hohenstein C. Comparison of Web- versus classroom-based basic ultrasonographic and EFAST training in two European hospitals. Ann. Emerg. Med., 2010, 56, 660-667.

64.       De Nicolo A, Parisini E, Zhong Q, Dalla Palma M, Stoeckert K, Domcheck S, Nathanson K, Caligo M, Vidal M, Cusick M, Garber J.  Multimodal assessment of protein functional deficiency supports pathogenicity of BRCA1 p.V1688del. Cancer Research, 2009, 69, 7030-7037.

63.       Chandra D, Parisini E, Mozaffarian D. Travel and the risk of venous thromboembolism: a systematic review and meta-analysis. Ann. Intern. Med., 2009, 151, 180-190.

62.       Relloso M, Cheng TY, Im JS, Parisini E, Roura-Mir C, DeBono C, Zajonc DM, Murga LF, Ondrechen MJ, Wilson IA, Porcelli SA, Moody DB. pH-Dependent interdomain tethers of CD1b  regulate its antigen capture. Immunity, 2008, 28, 774-786.

61.       Pai S-Y, Kang BY, Sabadini A, Parisini E, Truitt ML, Ho I-C. Distinct structural requirements of GATA-3 in the regulation of thymocyte and Th2 cell differentiation. J. Immunol., 2008, 180, 1050-1059.

60.       Parisini E, Higgins JMG, Liu JH, Brenner MB, Wang JH. The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism. J. Mol. Biol., 2007; 373, 401-411.

59.       Chang HC, Tan K*, Ouyang J*, Parisini E*, Liu JH, Le Y, Wang X, Reinherz EL, Wang JH. Structural and mutational analyses of a CD8αβ heterodimer and comparison with the CD8αα homodimer. Immunity, 2005, 23, 661-671.   (* equal contribution)

58.       Miller MM, Wang C, Parisini E, Coletta R, Goto RM, Lee SY, Barral DC, Townes M, Roura-Mir C, Ford H, Brenner MB, Dascher CC.  Characterization of two novel avian MHC-like genes reveals an ancient origin of the CD1 family.  Proc. Nat. Acad. Sci. USA, 2005; 102, 8674-8679.

57.       Bertrand L, Sayed MFR, Pei X-Y, Parisini E, Dhanaraj V, Bolanos-Garcia VM,  Allende JE,  Blundell TL. Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop. Acta Cryst., 2004; D60, 1698-1704.

56.       Sasada  T, Yang Y, Lai CC, Touma M, Clayton LK, Liu JH, Parisini E, Wang JH, Reinherz EL. Disparate peptide-dependent thymic selection outcomes in b2M-deficient mice versus TAP-1-deficient mice: implications for repertoire formation Eur. J. Immunol., 2003; 33, 368-380.

55.       Blundell TL, Burke DF, Chirgadze D, Dhanaraj V, Hyvönen M, Innis CA, Parisini E, Pellegrini L, Sayed  M, Sibanda BL.  Protein-protein interactions in receptor activation and intracellular signaling.  Biol. Chem., 2000; 381, 955-959.

54.       Böhm C, Schinnerl M, Buhert C, Zabel M, Labahn T, Parisini E, Reiser O.  A new strategy for the stereoselective synthesis of 1,2,3-trisubstituted cyclopropanes.  Eur. J. Org Chem., 2000; 2955-2965.

53.       Bes MT, Parisini E, Inda LA, Saraiva LM, Peleato ML, Sheldrick GM.  Crystal structure of ferredoxin from the green alga Chlorella fusca at 1.5 Å resolution.  Structure, 1999; 7, 1201-1211.

52.       Parisini E, Capozzi F, Lubini P, Lamzin V, Luchinat C, Sheldrick GM.  Ab initio determination and comparison of the crystal structure of two [Fe4-S4] high potential iron proteins (HiPIP) from Chromatium vinosum at atomic resolution.  Acta Cryst, Sec. D,  1999; 55, 1773-1784.

51.       Brotherton DH, Dhanaraj V, Wick S, Brizuela L, Domaille PJ, Volyanik E, Xu X, Parisini E, Smith BO, Archer SJ, Serrano M, Brenner SL, Blundell  TL, Laue ED.  Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d.  Nature, 1998; 395, 244-250.

50.       Schnitter C, Klimek K, Roesky HW, Albers T, Schmidt HG, Ropken C, Parisini E. Synthesis and characterization of tris (trimethylsilyl) methyl halide derivatives of aluminium: potential precursors for low-valent aluminium compounds. Crystal structures of [{Me3Si}3CAlF2}3], [(Me3Si)3CAlX2]·THF (X=Cl, Br, I) and [{(THF)2K(Me3Si)3CAlF2(μ-F)F2AlC(SiMe3)3}2]. Organometallics, 1998; 17, 2249-2257.

49.       Waezsada SD, Rennekamp C, Roesky HW, Ropken C, Parisini E. New aminometalanes of aluminium and gallium. Z. Anorg. und Allg. Chem., 1998; 624, 987-990.

48.       Mloston G, Celada M, Roesky HW, Parisini E, Ahlemann J-T.  Reactions of Thioketones with a Fluorinated Thione S-Imide.  Eur. J. Org. Chem., 1998, 459-465.

47.       Horchler S, Parisini E, Roesky HW, Schmidt H-G, Noltemeyer M.  Synthesis and structure of an anionic aluminium-nitrogen compound containing a ladder shaped core.  J. Chem. Soc., Dalton Trans,  1997; 2761-2763.

46.       Schnitter C, Roesky HW, Albers T, Schmidt H-G, Röpken C, Parisini E, Sheldrick GM.  Synthesis, structure and hydrolysis studies of dimethyltris(trimethylsilyl)-methylmetallanes of aluminium and gallium.  Chemistry-A Eur J., 1997; 3, 1783-1792.

45.       Voigt A, Murugavel R, Montero M, Wessel H, Liu F-Q, Roesky HW, Uson I, Albers T, Parisini E.  Soluble molecular titanosilicates.  Angew. Chem., 1997; 109, 1020; Angew. Chem. Int. Ed Engl., 1997; 36, 1001-1003.

44.       Waezsada S-D, Liu F-Q, Murphy EF, Roesky HW, Teichert M, Uson I, Schmidt H-G, Albers T, Parisini E, Noltemeyer M.  Aminodimethylalanes (R1R2NAlMe2) as useful synthetic precursors of aminoalane difluorides using trimethyltin fluoride; crystal structures of (2,6-i-Pr2C6H3)N(SiMe3)AlMe2 and (2,6-i-Pr2C6H3)N(SiMe3)AlF2. Organometallics, 1997; 16, 1260-1264.

43.       Murugavel R, Böttcher P, Voigt A, Walawalkar MG, Roesky HW, Parisini E, Teichert M, Noltemeyer M.  An efficient synthetic route to primary and secondary condensation products of silanetriols starting from (arylamino)trichlorosilanes.  J. Chem. Soc. Chem. Comm., 1996; 2417-2418.

42.       Schnitter C, Waezsada SD, Roesky HW, Teichert M, Uson I, Parisini E.  Synthesis and characterization of (4-fluorophenyl)amino-based amino- and iminometallanes of group 13. Crystal structures of (MeAlNRf)4, (MeMNRf)6 (M = Al, Ga) and (MeInNRf)4·4THF (Rf = 4-C6H4F).  Organometallics,  1997; 16,1197-1202.

41.       Mallors RL, Blake AJ, Parsons S, Johnson BFG, Dyson PJ, Braga D, Grepioni F, Parisini E. Arene-alkyne derivatives of Ru6C(CO)17: synthesis and structure of Ru6C(CO)126-arene)(μ3-C2Me2) (arene = C6H6-nMen, n=0-3) and Ru6C(CO)123-C16H16)(μ3-C2Me2). J. Organomet. Chem., 1997; 532, 133-142.

40.       Ahlemann J-T, Roesky HW, Murugavel R, Parisini E, Noltemeyer M, Schmidt H-G, Müller OR, Markovskii LN, Shermolovich YG.  The role of the 2,4,6-tris(trifluoromethyl)phenylamino group in stabilizing new phosphorus-, arsenic-, and germanium-containing main-group compounds and transition-metal derivatives.  Chem. Ber., 1997; 130, 1113-1121.

39.       Shah SAA, Dorn H, Roesky HW, Parisini E, Schmidt H-G, Noltemeyer M.  Derivatives of group 4 metal amido chlorides and fluorides: Synthesis, structure and characterisation of novel dimethyl and fluoro-chloro complexes.  J. Chem. Soc., Dalton Trans., 1996; 4143-4146.

38.       Dorn H, Shah SAA, Parisini E, Noltemeyer M, Schmidt H-G, Roesky HW.  Organometallic fluorides of zirconium and hafnium in the synthesis of carboxylate complexes: Molecular structures of Cp*ZrF(OCOCF3)2}2] and Cp*2Zr(OCOCF3)2] (Cp* = C5Me5).  Inorg. Chem., 1996; 35, 7181-7184.

37.       Shah SAA, Dorn H, Voigt A, Roesky HW, Parisini E, Schmidt H-G, Noltemeyer M.  Group 4 Metal Amido Fluorides and Chlorides: Molecular Structures and the First Comparison in Ethylene Polymerization Catalysis.  Organometallics,  1996; 15, 3176-3181.

36.       Murphy EF, Yu P, Dietrich S, Roesky HW, Parisini E, Noltemeyer M.  Synthesis and spectroscopic characterization of a series of substituted cyclopentadienyl Group 4 fluorides; crystal structure of the acetylacetonato complex (acac)2(-C5Me5)Zr(-F)SnMe3Cl.  J. Chem. Soc., Dalton Trans, 1996; 1983-1987.

35.       Kunzel A, Parisini E, Roesky HW, Sheldrick GM, Synthesis and characterization of trifluoro(η5-n-propyltetramethyl-cyclopentadienyl)metal(IV)-compounds of the elements of group IV.  J. Organomet. Chem., 1997; 536, 177-180.

34.       Voigt A, Walawalkar MG, Murugavel R, Roesky HW, Parisini E, Lubini P.  Organic-soluble neutral and ionic indium siloxane cages: Potential precursors for indium containing silicates.  Angew. Chem. Int. Ed. Engl., 1997; 36, 2203-2205.

33.       Voigt A, Murugavel R, Parisini E, Roesky HW.  Synthesis and structure of gallium siloxane cages : Model substances for gallium-containing silicates.  Angew. Chem. Int. Ed Engl., 1996; 35, 748-750.

32.       Blake AJ, Dyson PJ, Gaede PE, Johnson BFG, Braga D, Parisini E. The Synthesis and characterisation of Ru7C(CO)16(C9H8) and Ru7C(CO)16(C12H13): Facial -bonding and -bonding from the same ring system.  J. Chem. Soc., Dalton Comm., 1995; 3431-3432.

31.       Braga D, Byrne JJ, Grepioni F, Parisini E, Dyson PJ, Johnson BFG,  The synthesis and Characterization of Ru3 and Ru4 Clusters with Isopropenylbenzene and Diisopropenylbenzene ligands.  Organometallics, 1995; 14, 4892-4898.

30.       Johnson BFG, Shephard DS, Edwards AJ, Braga D, Parisini E, Raithby PR. Synthesis and characterization of guaiazulene derivatives of two ruthenium carbonyl clusters J. Chem Soc., Dalton Trans., 1995; 3307-3312.

29.       Braga D, Grepioni F, Parisini E, Dyson PJ, Ingham SL, Johnson BFG, Blake AJ.  Synthesis and Molecular structure of tetraruthenium clusters carrying facial arene ligands.  J. Chem. Soc., Chem. Comm., 1995; 537-538.

28.       Johnson BFG, Roberts YV, Parisini E, Benfield RE.  Solid-state studies into the possible rearrangement mechanisms for the fluxional behaviour of the tetranuclear carbonyls M4(CO)12 and their derivatives.  J. Organomet. Chem., 1994; 478, 21-28.

27.       Braga D, Grepioni F, Parisini E, Wadepohl H, Gebert S.  Dynamics and Molecular Aggregation in Crystalline Clusters of the Type [M(C5H5)]3(η222-arene).  J. Chem Soc, Dalton Trans., 1995; 1089-1093.

26.       Dyson PJ, Johnson BFG, Braga D, Grepioni F, Martin CM, Parisini E.  The synthesis, molecular and crystal structure of the bis(arene) hexaruthenium carbido-carbonyl isomers Ru6C(CO)11(C6H4Me2)(C6H5Me).  Inorg. Chim. Acta., 1995; 235, 413-420.

25.       Braga D, Grepioni F, Parisini E.  Crystal structures of salts of transition-metal halide clusters.  J. Chem. Soc., Dalton Trans., 1995; 287-291.

24.       Johnson BFG, Martin CM, Braga D, Grepioni F, Parisini E.  The synthesis and characterization of the octaruthenium benzene cluster [H4Ru8(CO)18(η6-C6H6)].  J. Chem. Soc., Chem Comm., 1994; 1253-1254.

23.       Johnson BFG, Martin CM, Blake AJ, Braga D, Parisini E, Chen H.  Sequential synthesis of some tetraosmium arene clusters.  J. Chem. Soc., Dalton Trans., 1994; 2167-2175.

22.       Braga D, Grepioni F, Martin CM, Parisini E, Dyson PJ, Johnson BFG. Co-crystallization of organometallic clusters: Homo- and hetero-molecular crystals of Ru6C(CO)14(η6-C6H4Me2) and Ru6C(CO)11(h6-C6H4Me2)2.  Organometallics, 1994; 13, 2170-2177.

21.       Dyson PJ, Johnson BFG, Martin CM, Blake AJ, Braga D, Grepioni F, Parisini E.  [2.2]Paracyclophane as a face-capping ligand: Conformational variability over the ruthenium triangle.  Organometallics,  1994; 13, 2113-2117.

20.       Johnson BFG, Parisini E, Roberts YV.  Application of the Ligand Polyhedral Model to the fluxionality of Fe3(CO)10(CNCF3)(L)  (L=CO, PMe3, PEt3, P(OMe)3 or P(OEt)3).  Organometallics, 1993; 12, 233-235.

19.       Benvenutti MH, Vargas MD, Braga D, Grepioni F, Parisini E, Mann BE.  Synthesis and X-Ray structure of the Tetranuclear Butterfly Iridium Cluster Ir4(CO)8L(h3-Ph2PC(H)CPh)(-PPh2),   L=PCy3,  and  13C{1H},  1H  and 31P{1H}  NMR Studies of the Compounds  L=CO, PCy3 and P(OMe)3.  Organometallics,  1993; 12, 2955-2961.

18.       Johnson BFG, Mallors R, Parisini E, Roberts YV.  Stereochemical changes in mononuclear complexes MLn  (n=10-12).  Polyhedron, 1993; 12, 897-901.

17.       Johnson BFG, Roberts YV, Parisini E. A new mechanism for the rearrangement of the icosahedral carboranes.  Inorg. Chim. Acta, 1993; 211, 17-21.

16.       Blake AJ, Dyson PJ, Johnson BFG, Martin CM, Nairn JGM, Parisini E, Lewis J.  New Synthetic Routes to [M3(CO)9(η222-C6H6)]  (M=Ru or Os).  J. Chem. Soc., Dalton Trans., 1993; 981-984.

15.       Braga D, Grepioni F, Milne P, Parisini E.  Cation control on the crystal organization of hexanuclear carbonyl cluster anions.  J. Amer. Chem. Soc., 1993; 115, 5115-5122.

14.       Dyson PJ, Johnson BFG, Reed D, Braga D, Grepioni F, Parisini E.  Hexanuclear arene clusters of ruthenium.  J. Chem. Soc., Dalton Trans., 1993; 2817-2825.

13.       Bailey PJ, Blake AJ, Dyson PJ, Johnson BFG, Lewis J, Parisini E. The synthesis, characterization and molecular structures of two mixed-metal octahedral carbide clusters, Ru5RhC(CO)145-C5Me5) and Ru5RhC(CO)95-C5Me5)(η5-C5H5)2 J. Organomet. Chem., 1993; 452, 175-179.

12.       Braga D, Grepioni F, Parisini E, Dyson PJ, Blake AJ, Johnson BFG, Synthesis, molecular and crystal structures of arene derivatives of [Ru6C(CO)17] J. Chem Soc., Dalton Trans., 1993; 2951-2957.

11.       Braga D, Grepioni, F, Marshall P, Parisini E. Molecular salts of high nuclearity cluster anions: cation control on the crystal structure. Inorg. Chim. Acta. 1993; 213, 121-127.

10.       Braga D, Grepioni, Parisini E, Johnson BFG, Martin CM, Nairn JGM, Lewis J, Martinelli M. Synthesis of [M3H(CO)9222-C6H7)  (M=Ru or Os). Molecular and crystal structure of the ruthenium cluster. J. Chem Soc., Dalton Trans., 1993; 1891-1895.

9.         Braga D, Grepioni F, Parisini E, Dyson PJ, Johnson BFG, Reed D, Shepherd DS, Bailey PJ, Lewis J. The synthesis, structural characterization and variable temperature 1H NMR study of the bis-toluene hexaruthenium  carbidocarbonyl cluster Ru6C(CO)116-C6H5Me) (η222-C6H5Me) J. Organomet. Chem., 1993; 462, 301-308.

8.         Johnson BFG, Parisini E. Application of the ligand polyhedral model to dicobalt octacarbonyl Inorg. Chim. Acta, 1992; 345-349.

7.         Blake AJ, Gould RO, Johnson BFG, Parisini E. Na2[Ru(NO2)4(NO)(OH)]·2H2O – a redetermination Acta Cryst., 1992; C48, 982-984.

6.         Braga D, Grepioni F, Johnson BFG, Parisini E, Martinelli MA Gallop MA, Lewis J. Trinuclear benzene clusters of ruthenium and osmium. J. Chem Soc., Dalton Trans., 1992; 807-812.

5.         Blake AJ, Gould RO, Johnson BFG, Parisini E. Redetermination of the structure of potassium tetranitropalladate (II). Acta Cryst., 1992; C48, 1749-1751.

4.         Johnson BFG, Roberts YV, Parisini E. Fluxional behaviour of the carbonyls [M3(CO12)] (M=Fe, Ru or Os). J. Chem. Soc., Dalton Trans., 1992; 2573-2578.

3.         Braga D, Grepioni F, Parisini E, Righi S. Dynamic processes in crystals of transition metal clusters. Mater. Chem. Phys., 1991; 29, 165-173.

2.         Braga D, Grepioni, F, Parisini E. Dynamic processes in the solid state. Diene flip and ring  reorientation in crystalline zircocene complexes. Organometallics, 1991; 10, 3735-3739

1.         Chen H, Johnson BFG, Lewis J, Braga D, Grepioni F, Parisini E. Reaction of Os4(-H)(CO)12 with 1,3-cyclohexadiene via chemical activation: Synthesis and structural characterization of Os4(-H)2(CO)106-C6H6) and Os4(CO)96-C6H6)(η4-C6H8) and their interconversion J. Chem. Soc., Dalton Trans., 1991; 215-219.

Awards

European Union Marie Curie International Reintegration Grant (FP7-PEOPLE-2010-RG, #268231, DETACH), 2010-2014, 100K Euro, “Destabilization of epithelial architecture by competition with E-cadherin homo-dimer formation: small molecule-induced disruption of epithelium integrity and functions. A structural study” (Principal Investigator)

 

Fondazione Cariplo (Italy), 2017-2020, 245K Euro, “CollAGEing: understanding and preventing age- and diabetes-related glycation in connective tissues” (Partner)

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.