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Edmondo Battista

Affiliated Researcher

Research Line

Bio-Logic Materials




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Edmondo Battista pursued his Laurea degree in Pharmaceutical Chemistry in October 2005, at University of Naples “Federico II”. Later on, he joined University of Magna Graecia of Catanzaro for the Doctoral School in Biomedical and Computer Engineering, at Biomaterials Lab of Dept of Experimental and Clinical Medicine. In January 2010 he defended his Ph.D. thesis entitled "Bioactivation of Polyester Scaffold Surface for Tissue Engineering: Surveying onto Immobilization and Effective Presentation of RGD-Peptide at Cell-Material Interface" with supervision of Ing. Filippo Causa.
The major topics of his Ph.D. research are in the field of modification and bioactivation of polymer surfaces acting as assay platforms and culture supports for tissue engineering, drug delivery and chemical analysis. Particular emphasis is laid on the chemical and physical surface characterization by using spectroscopic techniques (FTIR, Raman, SEM, AFM, CLSM) and specific colorimetric assays to the quantification of engrafted signals directly on the solid support. In addition the surface characterizations were complemented by studying the adsorption of bacteriophage and proteins to the metallic and polymeric surfaces. Kinetic and thermodynamic parameters of the process were investigated by quartz crystal microbalance (QCM), and the effect of serum protein adsorption on the presentation of bioactive compound was addressed in-vitro conditions.
From April 2004 to January 2005 he is undergraduate internship at Inbios srl, in Naples, a biotech company active in the R&D and production of peptides and peptidomimetics for pharmaceutical research. In the October 2005 he defended a research thesis on “Supramolecular Aggregates with Bioactive Peptides as Contrast Agents for Magnetic Resonance Imaging”, with supervision of Prof. Giancarlo Morelli at IBB-CNR and CIRPeB of University of Naples “Federico II”.

Selected Publications

A. International Journals

[A.6] F. Gentile, E. Battista, A. Accardo, M.L. Coluccio, M. Asande, G. Perozziello, G. Das, C. Liberale, F. De Angelis, P. Candeloro, P. Decuzzi, E. Di Fabrizio, Fractal structure can explain the increased hydrophobicity of nanoporous silicon films Microelectron. Eng. (2011), doi:10.1016/j.mee.2011.01.046

[A.5] T Calimeri, Battista E., F Conforti, P Neri, M T Di Martino, M Rossi, U Foresta, E Piro, F Ferrara, A.Amorosi, N Bahlis, K C Anderson, N Munshi, P Tagliaferri, F Causa And P Tassone (2011). A unique 3-D SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells. LEUKEMIA, ISSN: 0887-6924, doi: 10.1038/leu.2010.300

[A.4] Battista E., F.Causa, R. Della Moglie, P.A. Netti (2010). A novel platform for surface investigation of bio-conjugated ligands. EUROPEAN CELLS & MATERIALS, ISSN: 1473-2262

[A.3] Filippo Causa, Battista E., Raffaella Della Moglie, Daniela Guarnieri, Maria Iannone And Paolo A. Netti (2010). Surface Investigation on Biomimetic Materials to Control Cell Adhesion: The Case of RGD Conjugation on PCL. LANGMUIR, ISSN: 0743-7463, (DOI:10.1021/la100207q)

[A.2] Francesco Gentilea, Luca Tirinato, Battista E., Filippo Causa, Carlo Liberal, Enzo M. Di Fabrizioa, Paolo Decuzzi (2010). Cells preferentially grow on rough substrates. BIOMATERIALS, ISSN: 0142-9612, doi: 10.1016/j.biomaterials.2010.06.016


[A.1] Francesco Gentile, Luca Tiritano, Battista E., Enzo Mario Di Fabrizio, Paolo Decuzzi (2010). On the Mechanics of Cell Adhesion and Proliferation on Fractal Surfaces. BIOPHYSICAL JOURNAL, ISSN: 0006-3495 doi:10.1016/j.bpj.2009.12.4002 

B. International Conferences

[B.18] Teresa Calimeri, M.D., Edmondo Battista et al, SCID-Synth-Hu: a Novel Multiple Myeloma Model for In Vivo Expansion of Primary Cells – 52nd ASH Annual Meeting – Orlando, FL December 4-7, 2010

[B.17] Gentile F., Battista E., Accardo A., Coluccio M.L., Asande M., Perozziello G., Das G., Liberale C., De Angelis F., Candeloro P., Decuzzi P.,e and Di Fabrizio E. Fractal Structure Can Explain the Encreased Hydrophobicity of NanoPorous Silicon Films - MNE2010 Genova September 2010

[B.16] Causa F, Battista E, Della Moglie R, Netti PA. Surface Investigation of Bioconjugated Ligands, MRS Workshop Series, Denver October 2010 

[B.15] F.Causa, Battista E., R. Della Moglie, Guarnieri D., Iannone M., P.A. Netti E. Superfici di poliesteri bioattivate attraverso immobilizzazione di segnali peptidici – 10° Convegno Nazionale AIMAT, Capo Vaticano - Italy, September 2010

[B.14] Battista E., F.Causa, R. Della Moglie, P.A. Netti E. Bio-analytical platform to probe solid signals at cell materials interface. Gordon Conference Biointerface Science, Les Diablerets, Switzerland, September 5-10, 2010

[B.13] Battista E., Causa F, R. Della Moglie R,. Netti PA (2010). A novel platform for surface investigation of bio-conjugated ligands. 3nd NanoBio Conference, Zurich, Switzerland, August  23-28, 2010.

[B.12] E. Battista, F. Causa, P.A. Netti - A novel platform to map molecular or cellular recognition: the case of RGD on polymeric substrates- 1st Winter Workshop on Functional SPM in Bio and Chemical Physics , Modena, December 2009

[B.11] T. Calimeri, A. Bulotta, F. Conforti, G. Perri, F. Causa, E. Battista, A. De Angelis, M. T Di Martino., P. Neri, M. Rossi, A. Amorosi, P. Tagliaferri And P. Tassone - A NovelIn Vivo Biopolymeric Model For Ex-Vivo Expansion Of Primary  Multiple Myeloma Cells - XI Congresso Nazionale AIOM, Milan, October 2009

[B.10] A Gloria, Causa Filippo, Battista E., R. Della Moglie, T. Russo, S. Zeppetelli, P. A. Netti And L. Ambrosio (2008).RGD-Bioactivated PCL 3D Scaffolds: from Direct Assessment of Peptide to Cell-Bioactivity. In ESB, 22nd European Conference on Biomaterials, 07-11th September, 2009, Lausanne, CH

[B.9] A Gloria, F. Causa, E. Battista, R. Della Moglie, T. Russo, R. De Santis. P . A. Netti And L. Ambrosio (2008) Effect of surface modification via aminolysis on the mechanical performances of 3D fiber-deposited scaffolds. In ESB, 22nd European Conference on Biomaterials, 07-11th September, 2009, Lausanne, CH

[B.8] E. Battista, F. Causa, R. Della Moglie, A. Gloria And P. A. Netti Surface Conjugation of Bioactive Peptide Sequences on a Polyester Scaffold for Tissue Engineering- ICMAT & IUMRS-ICA 2009, 2nd Asian Biomaterial Congress (2ABMC), Hong Kong, June 2009

[B.7] E. Battista, F. Causa, R. Della Moglie, A. Gloria And P. A. Netti (2008). Grafting of GRGDS on poly-(epsilon)-caprolactone surface: a versatile procedure for bioactivation of three-dimensional porous scaffolds. In: 8th World Biomaterials Congress. Amsterdam, The Netherlands, May 28-1 June 2008

[B.6] V. Sanginario, F. Causa, E. Battista, R. Della Moglie, M. Iannone, S. Zeppetelli, P. A Netti (2008). Bioactive Injectable Vehicles based on PCL/PEG blends for cell and drug delivery. In: 8th World Biomaterials Congress. Amsterdam, The Netherlands, May 28-1 June 2008

[B.5] F Causa, E. Battista., R. Della Moglie, A. Gloria, P. A. Netti (2008). Engineered Polyesters Surfaces To Control Cell Functions: Enhancement Of Cell Adhesion. In: National Nanomedicine Congress. Genova, 28-29 November 2008

[B.4] F Causa, E. Battista., R. Della Moglie, P. A. Netti (2008). Immobilization of bioactive moieties on polycaprolactone scaffold surface: RGD sequence bioconjugation after aminolysis. In: E-MRS Fall Meeting 2008. Warsaw (Poland), 15-19 Semptember 2008

[B.3] F Causa, E. Battista., R. Della Moglie, P. A. Netti (2008). Aminolysis Of Poly-Epsilon-Caprolactone: A Route To Surface Bioactivation Of Polymeric Scaffolds. In: Proceedings of the Polymer Processing Society 24th Annual Meeting. Salerno, June 15-19, 2008

[B.2] F Causa, E. Battista., R. Della Moglie, P. A. Netti (2008). Bioactivation of polyesters for biomedical application: control over aminolysis reaction of polycaprolactone surface. In: Congresso Nazionale di Bioingengeria 2008 ATTI Pàtron, p. 351-352

[B.1] E. Battista., F Causa, P. A. Netti (2007). Bioattivazione di Scaffolds di Poliesteri Biodegradabili con Peptidi Segnale: Funzionalizzazione mediante Amminolisi. In: SIB2007 - CONGRESSO NAZIONALE BIOMATERIALI 2007. Bologna, 28-29 Maggio 2007

C. Patent

[C.1] Pierfrancesco Tassone, Filippo Causa, Pierosandro Tagliaferri, Teresa Calimeri, Maria Teresa Di Martino, Battista E. (2010). SCAFFOLD TRIDIMENSIONALE POLIMERICO DI POLICAPROLATTONE. 10107MS. FONDAZIONE T. CAMPANELLA – C.O.E.



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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.