I graduated in Biological Science at the University of Genova and I performed the PhD course in Molecular and Cellular Biology at Dibit San Raffaele Scientific Institute in Milan under the supervision of Dr. Giacomo Consalez. During my PhD I developed a strong background in molecular biology, being involved in the identification of new genes with regionalized expression during development of mouse brain through PCR-based differential screening techniques (Corradi 1996, Consalez 1996, Malgaretti 1997, Mariani Corradi 1998, Consalez 1999, Gimeno 2004). Subsequently, I focused on Ebf2, an helix loop helix transcription factor isolated with this approach, and I moved to the Mouse Genetics Laboratory directed by Prof. Wolfgang Wurst in Munich to generate an Ebf2 knock out mouse. Again at Dibit I characterized the Ebf2 mutant that showed cerebellar and peripheral nervous system phenotype (Corradi 2003, Croci 2006).
Since 2002 I have worked at the Department of Experimental Medicine of the Genova University and in 2005 I had the permanent position as Assistant Professor. I concentrated on the characterization of the peripheral neuropathy of Ebf2 KO mice and on the identification of Ebf2 target genes invoved in myelination defects. In parallel, I have started to work on the molecular mechanism of neuratrasmitter release in collaboration with Prof. Fabio Benfenati by studying the Synapsin KO mice and the implication of Synapsin genes in epilepsy and autism.
In the last years, my research activity focused on another epilepsy causative gene PRRT2 (Proline Rich Transmembrane protein 2) to get insight into its fuction, I developed, in collaboration with Gaslini Institute, the generation of Induced Pluripotent Stem Cells from fibroblasts of patients carrying mutation in PRRT2 and their differentiation to excitatory neurons.
Function of the synaptic protein Prrt2 in synaptic physiology and in movement disorders
Generation of Induced pluripotent stem cells from fibroblasts of epileptic patients in collaboration with G.Gaslini Institute.
Role of Ebf2 transcription factor in peripheral nerve myelination
Involvement of Synapsin genes in epilepsy and autism