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Amirreza Shayganpour

Post Doc

Research Line

Smart Materials

Center

IIT Central Research Labs Genova

Contacts

Via Morego, 30, Istituto Italiano di Tecnologia (IIT)
Contact Me

About

He did his Master's Degree in Manufacturing and Material Engineering in  2011, from University Technology Malaysia (UTM), Malaysia.

Currently, he's PhD Student in "BIOENGINEERING AND ROBOTICS " in the Scanning Probe Microscopy group of Nanophysics Department at the Italian Institute of Technology, Genova, Italy. 

His current research interests in the field of Nanotechnology deal with dental composites, Anodic Porous Alumina fabrication and its application in different areas.

Projects

Bioactive surfaces of anodic nanoporous oxides for biosensors/bioassays

Anodic porous alumina (APA) is a nanostructured form of aluminum oxide that has already proven to be biocompatible and thus is potentially useful for permanent implants in orthopedics and dentistry. Label-free surface-enhanced Raman scattering (SERS) sensing based on gold (Au) coated APA substrate has also been reported, with both thick (>10 um) and thin (500-100 nm) or ultrathin (<50 nm) forms of APA (TAPA, tAPA and utAPA, respectively). We aim at a novel combination of APA as both a SERS sensor surface and a cell seeding substrate, additionally endowed with drug delivery capabilities of the pores. Initially, loading and subsequent elution of test pharmaceutical molecules (e.g. Diclofenac) or active nanoparticles (e.g. antibacterial silver or remineralizing hydroxyapatite) will be tested. Means of triggering the release or at least modulating its rate, by control of either the medium (temperature, pH, etc) or a sealing layer on top (e.g. lipid bilayer or polymer film) will be explored. The presence of loaded drugs/mNPs and its release can will be verified by optical techniques based on fluorescence labeling or by quartz crystal microbalance (QCM). Indirectly, their effect can be assessed by SERS on different types of living cells cultured on the bioactive Au-tAPA substrates (e.g. osteoblasts, fibroblasts, and even neurons). Alternative metals would also be investigated in the future (mainly titanium). 

Use of nanoporous anodic oxides in dental materials

Thick anodic porous alumina (TAPA) can be used, after setting the membrane free and ball-milling it, as a nanoporous microfiller for advanced composites based on standard resin matrix (BisGMA). This first ever really nanostructured filler can in principle provide several advantages over traditional micro- or nano-fillers: the use of chemical bonding agent at the filler-matrix interface is not required, as it is replaced by the mechanical interlocking, which decreases the material aging; the pores can be used as reservoirs of bioactive agents, for their long-term release (e.g. antibacterial Chlorexidine or remineralizing phosphates); eventually, the frame structure of the nanoporous microfillers, which should be investigated by FE simulations, may release part of the local stress, either due to resin polymerization or during final operation. 

Another anodic oxide that may find applications in dentistry is that of titanium, the metal of which most permanent implants inserted in the bone are made. The anodization treatment is additive and can be combined with traditional micro-roughening (etching, sandblasting). Dental companies (Sweden&Martina, Nobel Biocare) have already patented anodization applied on their endosseous implants. However much room exists in improvement, in both aspects of surface pattern (texture, amplitude) and in functionalization of the surface to make it bioactive.

Selected Publications

  1. Amirreza Shayganpour, Marco Salerno, Barbara Salis, Silvia Dante. (2017), Towards a single bioactive substrate combining SERS-effect and drug release control based on thin anodic porous alumina coated with gold and with lipid bilayers, MRS advances, DOI:. 10.1557/adv.2016.676
  2. Marco Salerno, Amirreza Shayganpour, Barbara Salis, Silvia Dante. (2017), Surface-Enhanced Raman scattering of self-assembled thiol monolayers and supported lipid membranes on thin anodic porous alumina, Beilstein J. Nanotechnol., 8, 74–81.
  3. Amirreza Shayganpour, Andrea Pietro Reverberi, Marco Salerno, Bruno Fabiano. (2016), Electrochemical fabrication of anodic nanoporous titania for Photocatalytic degradation of pollutants, Chemical engineering transactions, 47.
  4. Giacomo Derchi, Enrico Manca, Amirreza Shayganpour, Antonio Barone, Alberto Diaspro, Marco Salerno. (2015), Combined characterization of the time response of impression materials via traditional and FTIR measurements, Dental materials Journal 8(5) 2387-2399.
  5. Amirreza Shayganpour, Alberto Rebaudi, Pierpaolo Cortella, Alberto Diaspro, Marco Salerno, (2015), Electrochemical coating of dental implants with anodic porous titania for enhanced osteointegration, Beilstein J. Nanotechnol., 6, 2183–2192.
  6. Jafari, H, Idris, M.H., Amirreza Shayganpour, (2013), Evaluation of significant manufacturing parameters in lost foam casting of thin-wall Al−Si−Cu alloy using full factorial design of experiment, Transaction of Nonferrous Metals Society China, Trans. Nonferrous Met. Soc. China 23, 2843−2851.
  7. Izman, S., Shayganpour, A., Idris, M.H., Jafari, H. (2012), DOE analysis of the influence of sand size and pouring temperature on porosity in LFC, Applied Mechanics and Materials, Vol. 121-126, 2012, pp. 2661-2665.
  8. S Izman, A Shayganpour, MH Idris. (2012), Effect of Casting Parameters on Porosity in LFC, Applied Mechanics and Materials 148, 1198-1201
  9. Shayganpour, A., Idris, M.H., Izman, S., Jafari, H. (2012), DOE applied to study the effect of process parameters on silicon spacing in lost foam Al-Si-Cu alloy casting, IOP Conference Series: Journal of Materials Science and Engineering, Volume 36, Issue 1, Article number 012035.
  10. Shayganpour, A., Idris, M.H., Izman, S. (2012), Effects of pouring temperature and slurry viscosity on heat transfer and surface roughness in lost foam casting, AIP Conference Proceedings, Volume 1440, pp. 1264-1270.
  11. A Shayganpour, MH Idris, S Izman, S Farahany. (2011), Variables Affecting Heat Transfer and Surface Roughness in LFC of LM 6 Aluminum Alloy, International Review of Mechanical Engineering 5 (7), 1168-1173
  12. Izman, S., Shayganpour, A., Idris, M.H. (2011), Analysis of the effect of sand size and vibration time on surface roughness in lost foam casting of LM6 alloy by design of experiments, Journal of Advanced Materials Research, Volume 337, pp. 422-425.

 

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