One researcher position in Computational Chemistry - [ Researcher ]

Workplace: Genova, IIT
Added on: 20/08/2018 - Expires on: 15/11/2018

One position as Researcher in Computational Chemistry applied to biomolecular systems and functionalized nanoparticles of pharmaceutical relevance is available in the Molecular Modeling and Drug Discovery Research Line at Istituto Italiano di Tecnologia.

The open position is for candidates with extensive experience in the broad field of computational modeling and simulation, including the following areas: MD simulations and enhanced sampling methods (e.g., metadynamics), QM and QM/MM calculations for catalysis, and structure-based drug design (Docking, virtual screening, FEP calculations, etc). Experience in method development, programming and scripting abilities are highly desirable.

Ideally, the candidate will be the most senior member of the computational group and will have his/her own research projects to conduct. He/she must be a team player, who possesses a lively sense of scientific curiosity. He/she must still be interested in mastering new computational methods, as required. At the same time, he/she must be willing and capable to help young students and postdocs in the lab, in their daily operations and technical trouble shooting. Targets of interest in the lab include membrane-bound proteins, ion channels and transporters, DNA and RNA processing enzymes, and other metalloproteins of pharmaceutical interest. The group includes also members working in the wet-lab performing medicinal chemistry and molecular biology. Importantly, this experimental part is fully integrated with the computational studies for drug discovery, which has already generated a few advanced patented classes of compounds for cancer and neurological disorders. There is also an exciting new research line on the computational design and characterization of functionalized nanoparticles, in collaboration with outstanding experimental labs.

In summary, the candidate will play a key role in our research work centered on multiscale molecular modeling to understand function and inhibition of pharmaceutically relevant enzymes and functionalized nanoparticles. He/she will work in close contact with other computational chemists, as well as medicinal chemists and experimentalists in a cutting-edge research environment with state-of-the-art instrumentations, computer power, and labs.

Thus, he/she must possess a PhD in chemistry, physics, or related disciplines, being an outstanding and highly-motivated scientist with a strong record of research productivity.

Successful candidate will be offered a competitive package commensurate to qualifications and experience.

Please send your application to This email address is being protected from spambots. You need JavaScript enabled to view it. quoting “Researcher Position in Computational Chemistry CB 74641” in the e-mail subject. Your application must including a detailed CV, a research statement and 3 representative publications. Candidates must also request three reference letters to be sent directly in PDF format to This email address is being protected from spambots. You need JavaScript enabled to view it.  by the referees. Please apply before November 15, 2018.

IIT was established in 2003 and successfully created a large-scale infrastructure in Genova and a network of 10 state-of-the-art laboratories countrywide with an international staff of about 1100 people from more than 50 countries. IIT's research endeavour focuses on high-tech and innovation, representing the forefront of technology with possible application from medicine to industry, computer science, robotics, life sciences and nano-biotechnologies.

Istituto Italiano di Tecnologia is an Equal Opportunity Employer that actively seeks diversity in the workforce.

 

Please note that the data that you provide will be used exclusively for the purpose of  professional profiles’ evaluation and selection, and in order to meet the requirements of Istituto Italiano di Tecnologia.

Your data will be processed by Istituto Italiano di Tecnologia, based in Genoa, Via Morego 30, acting as Data Controller, in compliance with the rules on protection of personal data, including those related to data security.

Please also note that, pursuant to articles 15 et. seq. of European Regulation no. 679/2016 (General Data Protection Regulation), you may exercise your rights at any time by contacting the Data Protection Officer (phone +39 010 71781 - email: This email address is being protected from spambots. You need JavaScript enabled to view it.).

Contacts

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Involved Research lines
Molecular Modeling and Drug Discovery

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.