We are seeking a post-doctoral candidate to join the Cancer Biology team led by Dr. Stefano Campaner at the Center for Genomic Science of IIT@SEMM (http://genomics.iit.it ) located in Milan, Italy. The successful candidate will be involved in the study of the transcriptional co-activators YAP and TAZ, focusing in particular on their role in lineage restriction and in the control of cellular proliferation. This study is based on a combination of in-vivo and in-vitro studies aimed at dissecting the role of YAP/TAZ by using genome wide chromatin association studies (ChIP-seq) coupled with genome wide mRNA expression.
We seek highly motivated, ambitious and talented scientists to join our lab. The ideal candidate should be highly skilled in basic molecular biology techniques, cell culture and basic biochemistry. Previous experience with in vivo technoques and/or Next Generation Sequencing will be a plus.
Our group has a long-standing interest in understanding the molecular mechanisms of transformation induced by oncogenic transcription factors such as Myc and the Hippo pathway co-activators YAP and TAZ. We make use of cellular as well as animal models to perform loss of function and gain of function studies coupled with genome wide analysis (ChIP-seq, RNA-seq, sc-RNA-seq). The scope of our research is to (i) identify basic rules in gene regulation, (ii) define the role of oncogenic transcription factors at the different stages of cancer progression and (iii) exploit reverse genetics to discover synthetic liabilities in preclinical animal models.
Required skills and experience
Selected candidates will be initially interviewed by Skype.
Application deadline: May 10, 2018
Fondazione Istituto Italiano di Tecnologia – IIT (www.iit.it) - was founded with the objective of promoting Italy’s technological development and further education in science and technology. In this sense IIT is committed to achieving its scientific program, which sees a major inspirational principle in the integration between basic scientific research and the development of technical applications. Research at IIT cover scientific areas of high innovative content, representing the most advanced frontiers of modern technology, with wide application possibilities in various fields from medicine to industry, from computer science to robotics, life sciences and nanobiotechnology.
The Center for Genomic Science of IIT@SEMM (http://genomics.iit.it ) is located in Milan, Italy and is one of IIT’s national nodes. The Center benefits from state-of-the-art facilities and advanced technologies. The successful candidate will be integrated in a lively community of experimental and computational scientists.
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Istituto Italiano di Tecnologia is an Equal Opportunity Employer that actively seeks diversity in the workforce.