POST DOC CALL in “Molecular processes relevant for Amyotrophic Lateral Sclerosis (ALS) initiation and progression” - [ Postdoc ]

Workplace: Roma, IIT@SAPIENZA
Added on: 03/11/2017 - Expires on: 30/11/2017

A postdoctoral position in “Molecular processes relevant for Amyotrophic Lateral Sclerosis (ALS) initiation and progression” will be available in the Center for Life Nanoscience  at Istituto Italiano di Tecnologia (CLNS@SAPIENZA, Rome, Italy).

The project will explore:

  • The molecular circuitries controlling normal and pathological neuronal differentiation and activity.
  • The molecular basis of neuromuscular diseases with specific interest in ALS pathogenesis.
  • The pathogenic mechanisms of ALS-associated proteins involved in RNA metabolism.
  • The role of long non coding RNAs (lncRNAs) and circular RNAs (circRNAs) in MN differentiation and in neuromuscular diseases with specific interest in the ALS pathology.
  • The use of in vitro motor neuron differentiation from mouse Embryonic Stem Cells (mESC) and from human induced Pluripotent Stem Cells (iPS, from controls and ALS patients).
  • The use of in vivo animal model systems for studying the activity of non coding RNAs with a relevant role in MN differentiation and function.
  • Candidates should have a PhD in Molecular Biology or Cell Biology or Biochemistry.

    The position requires experience in some of the indicated subjects:

  • Knowledge on basic mechanisms of gene expression control.
  • Techniques of advanced molecular, biochemical, cellular and imaging methodologies for the study of cell differentiation.
  • Characterization and function of non coding RNAs.
  • Expertise on cell cultures and on manipulation of mESCs and human iPS.
  • Computational skills for RNAseq data analysis
  • We value candidates with a proactive attitude and results-oriented mind-set, good interpersonal and communication skills and ability to work effectively within an interdisciplinary research team. An internationally competitive salary, dependent on experience, will be offered.

    Interested applicants should submite their CV, list of publications, a statement of research interests, and names of two referees to katia.broccoletti@iit.it

    Please quote “Molecular processes relevant for Amyotrophic Lateral Sclerosis (ALS) initiation and progression - BC 72946” as your application reference.

    Please apply before: November 30, 2017.

    Istituto Italiano di Tecnologia IIT (http://www.iit.it) is a private law Foundation, created with special Government Law no. 269 of September 30th 2003, with the objective of promoting Italy's technological development and higher education in science and technology. Research at IIT is carried out in highly innovative scientific fields with state-of-the-art technology.

    In order to comply with the Italian law (art. 23 of Privacy Law of the Italian Legislative Decree n. 196/03), we have to kindly ask the candidate to give his/her consent to allow IIT to process his/her personal data. We inform you that the information you provided will be used solely for the purpose of assessing your professional profile to meet the requirements of Istituto Italiano di Tecnologia.

    Your data will be processed by Istituto Italiano di Tecnologia, with headquarters in Genoa, Via Morego, 30, acting as the Data Holder, using computer and paper based means, observing the rules on protection of personal data, including those relating to the security of data.

    Please also note that, pursuant to art. 7 of Legislative Decree 196/2003, you may exercise your rights at any time as a party concerned by contacting the Data Manager.

    Istituto Italiano di Tecnologia is an Equal Opportunity Employer that actively seeks diversity in the workforce.

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