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People ■ Fabio Benfenati
Fabio Benfenati's foto

Fabio Benfenati

NBT / Synaptic Neuroscience

Department Director
Address Via Morego 30
City Genova State/Region Genova
ZIP Code 16163
Country Italy
Phone +39 010 71781 434
Mobile Phone +39 348 4406832
Fax +39 010 720321
IM Address fabio.benfenati-54 (Skype)

Followers

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Bio

 Personal Data:

  • Date and Place of Birth:November 5, 1954, Bologna (Italy)
  • Nationality and Status:Italian citizen, married, two children

Current position:

  • Director, Department of Neuroscience and Brain Technologies, The Italian Institute of Technology
  • Full professor of Neurophysiology, University of Genova Medical School
  • Adjunct Professor, The Rockefeller University, New York, NY, USA
  • Head, Laboratory of Molecular and Cellular Neurophysiology, University of Genova
  • Coordinator, Ph.D. Course in Experimental Neuroscience, University of Genova

Education:

  • 1973:“Enrico Fermi” High School, Bologna (Italy) Degree: Baccalaureate (60/60)
  • 1979: University of Bologna, School of Medicine Degree: Doctor of Medicine (110/110 cum laude)
  • Field of Study: Neurochemistry 1983: University of Bologna, School of Medicine, Postdoctoral School of Neurology
  • Degree: Specialist in Neurology Field of Study: Neurophysiology

PROFESSIONAL CAREER:

  • 1980-1983:"Accademia Nazionale dei Lincei" fellow at the "Mario Negri" Institute (Milano)
  • 1983-1991:Assistant Professor at the Institute of Human Physiology, University of Modena
  • 1983-1984:Post-doctoral fellow at the Department of Histology and Neurobiology at the Karolinska Institutet, Stockholm (Sweden) directed by Professor Kjell Fuxe
  • 1986-1989Research Associate, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York (USA) directed by Professor Paul Greengard (Nobel Laureate in 2000)
  • 1990-1995:Guest Investigator, The Rockefeller University, New York (USA)
  • 1992-2000:Associate Professor of Human Physiology and Head of the Laboratory of Molecular Neuroscience at the Department of Neuroscience, University of Roma Tor Vergata (Italy)
  • 1996-present:Member of the Adjunct Faculty, TheRockefeller University, New York (USA)
  • 2000-present:Full Professor of Neurophysiology, University of Genova, School of Medicine (Italy); Head of the Laboratory of Molecular and Cellular Neurophysiology, Coordinator of the Section of Human Physiology, Department of Experimental Medicine, University of Genova (Italy)
  • 2006-present:Director, Department of Neuroscience and Brain Technologies, The Italian Institute of Technology, Genova (Italy)

Honors and Awards

  • 1979:"Thesis Prize" and thesis publication by the University of Bologna
  • 1980:"Giuseppe Levi" Foundation, Accademia Nazionale dei Lincei Prize for Neurobiology
  • 1981-1982:“Anna Villa Rusconi” Foundation Fellowship
  • 1986-1987:Fogarty International Center Fellowship from the US Public Health Service
  • 1988:“Italian Society for Neuroscience” Prize for young neuroscientists
  • 1992-1996:Board Member of the Italian Society for Neuroscience
  • 1997:Fullbright Advanced Research and University Lecturing Award
  • 1999-2003:Research Awards from the Foundation of the Fisher Center for Alzheimer’s Disease Research at The Rockefeller University, NY, USA
  • 2003-2005:President, Italian Society for Neuroscience
  • 2004-2006: Board Member of the Italian Federation for Life Sciences (FISV)
  • 2005-2008:Vice-President, National Institute for Neuroscience
  • 2007-present:Member, “Commissione Ministeriale Biosicurezza e Biotecnologie”
  • 2008-present: Chairman of the IBRO International Program Committee, 8th World Congress of the International Brain Research Organization, Florence (Italy) July 14-19, 2011.
  • 2009-2011:President, The Italian Physiological Society

Research Activity

Author of

  • 169 papers on refereed international journals (total impact factor: 854; including papers in Nature, Science, Neuron, Proc. Natl. Acad. Sci. USA, J. Cell Biol., EMBO J., J. Neurosci.),
  • 42 papers in international books
  • over 300 abstracts to international meetings.

Main scientific contributions

  • The main subjects of investigation of Dr. Fabio Benfenati in the last 25 years have been the molecular mechanisms of information transfer among neurons and the role of signal transduction pathways and protein phosphorylation in these processes. He has begun working in the field of synaptic transmission in Paul Greengard’s laboratory in 1986, starting a collaboration with him that is still ongoing.
  • By using a combination of experimental techniques ranging from cell biology, biochemistry, biophysics, live imaging, electrophysiology and molecular biology, including the generation of genetically altered mice, dr. Benfenati has addressed the mechanisms of synaptic communication andthe problem of how neurons can change the efficiency of the information transfer at synapses to adapt to diverse environmental situations.

 Personal Data:

  • Date and Place of Birth:November 5, 1954, Bologna (Italy)
  • Nationality and Status:Italian citizen, married, two children

Current position:

  • Director, Department of Neuroscience and Brain Technologies, The Italian Institute of Technology
  • Full professor of Neurophysiology, University of Genova Medical School
  • Adjunct Professor, The Rockefeller University, New York, NY, USA
  • Head, Laboratory of Molecular and Cellular Neurophysiology, University of Genova
  • Coordinator, Ph.D. ...

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Selected Publications

SELECTED PUBLICATIONS IN REFEREED JOURNALS

1. Pang D.T., Wang J.K., Valtorta F., Benfenati F., Greengard P. Protein tyrosine phosphorylation in synaptic vesicles. Proc. Natl. Acad. Sci. USA 85: 762‑766, 1987.

2. Bähler M., Benfenati F., Valtorta F., Czernik A.J., Greengard P.

Characterization of synapsin I fragments by cysteine-specific cleavage: a study of their interactions with F-actin.

J. Cell Biol. 108: 1841-1849, 1989.

3. Benfenati F., Bähler M., Brunner J., Greengard P.

Electrostatic and hydrophobic interactions of synapsin I with phospholipid vesicles.

J. Cell Biol. 108:, 1851-1862, 1989.

4. Benfenati F., Bähler M., Jahn R., Greengard P.

Interaction of synapsin I with small synaptic vesicles: distinct sites in synapsin I bind to vesicle phospholipids and vesicle proteins.

J. Cell Biol. 108: 1863-1872, 1989.

 

5. Bähler M., Benfenati F., Valtorta F., Greengard P.

The synapsins and the regulation of synaptic function.

Bioessays 12: 259-263, 1990.

 

6. Benfenati F., Neyroz P., Bähler M., Masotti L., Greengard P.

Time-resolved fluorescence study of the neuron-specific phosphoprotein synapsin I. Evidence for phosphorylation-induced conformational changes.

J. Biol. Chem. 265: 12584-12595, 1990.

 

7. De Camilli P., Benfenati F., Valtorta F., Greengard P.

The synapsins.

Annu. Rev. Cell Biol. 6: 433-460, 1990.

 

8. Benfenati F., Valtorta F., Greengard P.

Computer modeling of synapsin I binding to synaptic vesicles and F-actin: implications for the regulation of neurotransmitter release.

Proc. Natl. Acad. Sci. USA 88: 575-579, 1991.

 

9. Benfenati F., Valtorta F., Chieregatti E., Greengard P.

Interaction of free and synaptic vesicle-bound synapsin I with F-actin.

Neuron, 8: 377-386, 1992.

 

10. Valtorta F., Benfenati F., Greengard P.

Structure and function of the synapsins.

J. Biol. Chem., 267: 7195-7198, 1992.

 

11. Valtorta F., Greengard P., Fesce R., Chieregatti E., Benfenati F.

Effects of the neuronal phosphoprotein synapsin I on actin polymerization. I. Evidence for a phosphorylation-dependent nucleating effect.

J. Biol Chem., 267: 11281-11288, 1992.

 

12. Fesce R., Benfenati F., Greengard P., Valtorta F.

Effects of the neuronal phosphoprotein synapsin I on actin polymerization. II. Analytical interpretation of kinetic curves.

J. Biol Chem., 267: 11289-11299, 1992.

 

13. Schiavo G., Poulain B., Rossetto O., Benfenati F., Tauc L., Montecucco C.

Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.

EMBO J. 11: 3577-3583, 1992.

 

14. Benfenati F., Valtorta F., Rubenstein J.L., Gorelick F., Greengard P., Czernik A.J.

Synaptic vesicle-associated Ca2+/calmodulin-dependent protein kinase II is a binding protein for synapsin I.

Nature 359: 417-420, 1992.

 

15. Schiavo G., Benfenati F., Poulain B., Rossetto O., Polverino de Laurato P., DasGupta B. R., Montecucco C.

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin-2.

Nature, 359: 832-835, 1992.

 

16. Greengard P., Valtorta F., Czernik A. J., Benfenati F.

Synaptic vesicle phosphoproteins and regulation of synaptic function.

Science, 259: 780-785, 1993.

 

17. Facchiano F., Benfenati F., Valtorta F., Luini A.

Covalent modification of synapsin I by tetanus toxin-activated transglutaminase.

J. Biol. Chem., 268: 4588-4591, 1993.

 

18. Facchiano F., Valtorta F., Benfenati F., Luini A.

The transglutaminase hypothesis for the mechanisms of action of tetanus toxin.

Trends Biochem. Sci., 18: 327-329, 1993.

 

19. Schiavo G., Poulain B., Benfenati F., DasGupta B. R., Montecucco C.

Novel targets and catalytic activity for bacterial protein toxins.

Trends Microbiol., 1: 170-174, 1993.

 

20. Schiavo G., Rossetto O., Catsicas S., Polverino da Laureto P., DasGupta B.B., Benfenati F., Montecucco C.

Identification of the nerve terminal targets of Botulinum neurotoxin serotypes A, D, and E.

J. Biol. Chem., 268: 23784-23787, 1993.

 

21. Benfenati F., Valtorta F., Rossi M.C., Onofri F., Sihra T., Greengard P.

Interactions of synapsin I with phospholipids: possible role in synaptic vesicle clustering and in the maintenance of bilayer structures.

J. Cell Biol., 123: 1845-1855, 1993.

 

22. McPherson P.S., Czernik A.J., Chilcote T.J., Onofri F., Benfenati F., Greengard P., Schlessinger J., De Camilli P.

Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I.

Proc. Natl. Acad. Sci. USA, 91: 6486-6490, 1994.

 

23. Ceccaldi P., Grohovaz F., Benfenati F., Chieregatti E., Greengard P., Valtorta F.

Dephosphorylated synapsin I anchors synaptic vesicles to actin cytoskeleton: an analysis by videomicroscopy.

J. Cell Biol., 128: 905-912, 1995.

 

24. Nielander H.B., Onofri F., Valtorta F., Schavo G., Montecucco C., Greengard P., Benfenati F. Phosphorylation of VAMP/synaptobrevin in synaptic vesicles by endogenous protein kinases.

J. Neurochem., 65: 1712-1720, 1995.

 

25. Barrie A., Chieregatti E., Miloso M., Benfenati F., Valtorta F.

Epidermal growth factor-mediated inhibition of neurotransmitter release from rat forebrain synaptosomes.

Mol. Pharmacol., 49: 399-403, 1996.

 

26. Benfenati F., Onofri F., Czernik A.J., Valtorta F.

Biochemical and functional characterization of the synaptic vesicle-associated form of Ca2+/calmodulin-dependent protein kinase II.

Mol. Brain Res., 40: 297-309, 1996.

 

27. Jovanovic J., Benfenati F., Siow Y.L., Sihra T.S., Sanghera J.S., Pelech S.L., Greengard P., Czernik A.J.

Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions.

Proc. Natl. Acad. Sci. USA, 93: 3679-3683, 1996.

 

28. Stefani G., Onofri F., Valtorta F., Vaccaro P., Greengard P., Benfenati F.

Kinetic analysis of the phosphorylation-dependent interactions of synapsin I with synaptic vesicles: a study by fluorescence resonance energy transfer.

J. Physiol., 504: 501-515, 1997 .

 

29. Nielander H.B., Onofri F., Schaeffer E., Menegon A., Fesce R., Valtorta F., Greengard P., Benfenati F.

Phosphorylation-dependent effects of synapsin IIa on actin polymerization and network formation.

Eur. J. Neurosci., 9: 2712-2722, 1997 .

 

30. Onofri F., Giovedì S., Vaccaro P., Czernik A.J., Valtorta F., De Camilli P., Greengard P., Benfenati F.

Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity.

Proc. Natl. Acad. Sci. USA 94: 12168-12173, 1997.

 

31. Kao H-T., Porton B., Czernik A.J., Feng J., Yiu G., Haring M., Benfenati F., Greengard P.

A third member of the synapsin gene family.

Proc. Natl. Acad. Sci. USA 95: 4667-4672, 1998.

 

32. Benfenati F., Onofri F., Giovedì S.

Protein-protein interactions and protein modules in the control of neurotransmitter release.

Phil. Trans. R. Soc. Lond. B 354: 243-257, 1999.

 

33. Leoni C. Menegon A., Benfenati F., Toniolo D., Pennuto M., Valtorta F.

Neurite extension occurs in the absence of regulated exocytosis in PC12 subclones.

Mol. Biol. Cell, 10, 2919-2931, 1999.

 

34. Onofri F., Giovedì S., Kao H-T., Valtorta F., Bongiorno Borbone L., De Camilli P., Greengard P, Benfenati F.

Specificity of the binding of synapsin I to Src homology-3 domains.

J. Biol. Chem., 275, 29857-29867, 2000.

 

35. D’Arcangelo G., Tancredi V., Onofri F., D’Antuono M., Giovedì S., Benfenati F.

Interleukin-6 inhibits neurotransmitter release and the spread of excitation in the rat cerebral cortex.

Eur. J. Neurosci. 12, 1241-1252, 2000.

 

36. Tancredi V., D’Antuono M., Cafè C., Giovedì S., Buè M.C., D’Ancangelo G., Onofri F., Benfenati F..

The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of MAP kinase Erk.

J. Neurochem., 75, 634-643, 2000.

 

37. Fiumara F., Ghirardi M., Onofri F., Benfenati F., Montarolo P.G.

Intracellular injection of synapsin I induces neurotransmitter release in C1 neurons of Helix pomatia contacting a wrong target.

Neuroscience, 104: 271-280, 2001.

 

38. Humeau Y., Doussau F., Vitiello F.,Greengard P., Benfenati F., Poulain B.

Synapsin controls transition between multiple synaptic vesicle stores during short-term plasticity.

J. Neurosci., 21: 4195-4206, 2001.

 

39. Jaffrey S.R., Benfenati F., Snowman A.M., Czernik A.J., Snyder S.H.

Neuronal nitric oxide synthase localization mediated by a ternary complex with synapsin and CAPON.

Proc. Natl. Acad. Sci. USA, 99: 3199-3204, 2002.

 

40. Bongiorno-Borbone L., Onofri F., Giovedi S., Ferrari R., Girault J-A., Benfenati F.

The translocation of focal adhesion kinase in brain synaptosomes is regulated by phosphorylation and actin assembly.

J. Neurochem., 81: 1212-1222, 2002.

 

41. Pennuto M., Dunlap D., Contestabile A., Benfenati F., Valtorta F.

Fluorescence resonance energy transfer detection of synaptophysin I and vesicle-associated membrane protein-2 interactions during exocytosis from single live synapses.

Mol. Biol. Cell, 13: 2706-2717, 2002 .

 

42. Menegon A., Verderio C., Leoni C., Benfenati F., Czernik A.J., Greengard P., Matteoli M., Valtorta F.

Spatial and temporal regulation of Ca2+/calmodulin-dependent protein kinase II activity in developing neurons.

J. Neurosci., 22:7016-7026, 2002.

 

43. Hsieh-Wilson L.C., Benfenati F., Snyder G.L., Allen P.B., Nairn A.C., Greengard P.

Phosphorylation of spinophilin modulates its interaction with actin filaments.

J. Biol. Chem. 278: 1186-1194, 2003.

 

44. Schenk U., Verderio C., Benfenati F., Matteoli M.

Regulated delivery of AMPA receptor subunits to the presynaptic membrane.

EMBO J., 22: 558-568, 2003.

 

45. Guo J., Wenk M.R., Pellegrini L., Onofri F., Benfenati F., De Camilli P.

Phosphatidylinositol 4-kinase type II? is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles.

Proc. Natl. Acad. Sci. USA, 100, 3995-4000, 2003.

 

46. Messina S., Onofri F., Bongiorno Borbone L., Giovedì S., Valtorta F., Girault J-A., Benfenati F.

Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin

J. Neurochem., 84: 253-265, 2003.

 

47. Raiteri L., Bonanno G., Giovedì S., Benfenati F., Raiteri M.

Cellular mechanisms of the acute increase of glutamate release induced by nerve growth factor in rat cerebral cortex.

Neuropharmacology, 44: 390-402, 2003.

 

48. Pennuto M., Bonanomi D., Benfenati F., Valtorta F.

Synaptophysin I controls the targeting of VAMP2/synaptobrevin II to synaptic vesicles.

Mol. Biol. Cell, 14: 4909-4919, 2003.

 

49. Ghirardi M., Benfenati F., Giovedì S., Fiumara F., Milanese C., Montarolo P.G.

Inhibition of neurotransmitter release by a nonphysiological target requires protein synthesis and involves cAMP-dependent and mitogen-activated protein kinases.

J. Neurosci. 24: 5054-5062, 2004.

 

50. Valtorta F., Pennuto M., Bonanomi D., Benfenati F.

Synaptophysin: leading actor or walk-on role in synaptic vesicle exocytosis?

Bioessays, 26: 445-453, 2004.

 

51. Benfenati F., Ferrari R., Onofri F., Arcuri C., Giambanco I., Donato R.

S100A1 codistributes with synapsin I in discrete brain areas and inhibits the F-actin-bundling activity of synapsin I.

J. Neurochem., 89: 1260-1270, 2004.

 

52. Fiumara F., Giovedì S., Menegon A., Milanese C., Merlo D., Montarolo P.G., Valtorta F., Benfenati F., Ghirardi M.

Phosphorylation by protein kinase A is required for the enhancement of neurotransmitter release induced by synapsin.

J. Cell Sci. 117: 5145-5154, 2004.

 

53. Pera I., Stark R., Kappl M., Butt H-J., Benfenati F.

Using the atomic force microscope to study the interaction between two solid supported lipid bilayers and the influence of synapsin I.

Biophys. J. 87: 2446-2455, 2004.

 

54. Giovedì S., Vaccaro P., Valtorta F., Darchen F., Greengard P., Cesareni G., Benfenati F.

Synapsin is a novel Rab3 effector protein on small synaptic vesicles. I. Identification and characterization of the synapsin I-Rab3 interactions in vitro and in intact nerve terminals.

J. Biol. Chem. 279: 43760-43768, 2004.

 

55. Giovedì S., Darchen F., Valtorta F., Greengard P., Benfenati F.

Synapsin is a novel Rab3 effector protein on small synaptic vesicles. II. Functional effects of the Rab3A-synapsin I interaction.

J. Biol. Chem. 279: 43769-43779, 2004.

 

56. Hilfiker S., Benfenati F., Doussau F., Nairn A.C., Czernik A.J., Augustine G.J., Greengard P.

Structural domains involved in the regulation of transmitter release by synapsins.

J. Neurosci. 25: 2658 - 2669, 2005.

 

57. Lane-Guermonprez L., Morot-Gaudry-Talarmain Y., Meunier F-M., O’Regan S., Onofri F., Le Caer J-P., Benfenati F.

Synapsin associates with cyclophilin B in an ATP- and cyclosporin A-dependent manner.

J. Neurochem., 93: 1401-1411, 2005.

 

58. Bonanomi D., Menegon A., Miccio A., Ferrari G., Corradi A., Kao H-T., Benfenati F., Valtorta F.

Phosphorylation of Synapsin I by cyclic AMP-dependent protein kinase controls synaptic vesicle dynamics in developing neurons.

J. Neurosci., 25: 7299-7308, 2005.

 

59. Bongiorno-Borbone L., Kadare G., Benfenati F., Girault J-A.

FAK and PYK2 interact with SAP90/PSD-95-Associated Protein-3.

Biochem. Biophys. Res. Commun. 337: 641-646, 2005.

 

60. Collo G., Goffi F., Merlo Pich E., Baldelli P., Benfenati F., Spano P.F.

Immature neuronal phenotype derived from mouse skin precursor cells differentiated in vitro.

Brain Res., 1109: 32-36, 2006.

 

61. Menegon A., Bonanomi D., Albertinazzi C., Lotti F., Ferrari G., Kao H-T., Benfenati F., Baldelli P., Valtorta F.

Protein kinase A-mediated synapsin I phosphorylation is a central modulator of Ca2+-dependent synaptic activity.

J. Neurosci., 26: 11670-11681, 2006

 

62. Fassio A., Merlo D., Mapelli J., Menegon A., Corradi A., Mete M., Zappettini S., Bonanno G., Valtorta F., D\\'Angelo E., Benfenati F.

The synapsin domain E accelerates the exo-endocytotic cycle of synaptic vesicles in cerebellar Purkinje cells.

J. Cell Sci., 119: 4257-4268, 2006.

 

63. Bonanomi D., Benfenati F., Valtorta F.

Protein sorting in the synaptic vesicle life cycle.

Prog Neurobiol., 80: 177-217, 2006.

 

64. Santillo M, Secondo A, Seru R, Damiano S, Garbi C, Taverna E, Rosa P, Giovedi S, Benfenati F, Mondola P.

Evidence of calcium- and SNARE-dependent release of CuZn superoxide dismutase

from rat pituitary GH3 cells and synaptosomes in response to depolarization.

J. Neurochem. 102:679-685, 2007

 

65. Bragina L., Candiracci C., Barbaresi P.,Giovedì S., Benfenati F., Conti F.

Heterogeneity of glutamatergic and GABAergic release machineries in cerebral cortex.

Neuroscience, 146: 1829-1840, 2007.

 

66. Onofri F, Messa M, Matafora V, Bonanno G, Corradi A, Bachi A, Valtorta F, Benfenati F.

Synapsin phosphorylation by SRC tyrosine kinase enhances SRC activity in synaptic vesicles.

J. Biol. Chem., 282: 15754-15767, 2007.

 

67. Bonanomi D, Rusconi L, Colombo CA, Benfenati F, Valtorta F.

Synaptophysin I selectively specifies the exocytic pathway of synaptobrevin

2/VAMP2.

Biochem J,. 404: 525-534, 2007.

 

68. Benfenati F.

Synaptic plasticity and the neurobiology of learning and memory.

Acta Biomed., 78: 58-66, 2007.

 

69. Awizio AK, Onofri F, Benfenati F, Bonaccurso E.

Influence of synapsin I on synaptic vesicles: an analysis by force-volume-mode of the atomic force microscope and dynamic light scattering.

Biophys J,. 93: 1051-1060, 2007

 

70. Evergren E., Benfenati F., Shupliakov O.

The synapsin cycle: a view from the synaptic endocytic zone.

J. Neurosci. Res. 85: 2648-2656, 2007.

 

71. Fiumara F., Milanese C., Corradi A. , Giovedì S., Leitinger G., Menegon A., Montarolo P.G., Benfenati F., Ghirardi M.

Synapsin domain A phosphorylation is required for post-tetanic potentiation.

J. Cell Sci. 120: 3228-3237, 2007.

 

72. Humeau Y., Doussau F., Popoff M.R., Benfenati F., Poulain B.

Fast changes in the functional status of release sites during short-term plasticity: involvement a frequency-dependent bypass of Rac at Aplysia synapses.

J. Physiol. (London) 583: 983-1004,2007.

 

73. Baldelli P., Fassio A., Valtorta F., Benfenati F.

Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.

J. Neurosci.27:13520-13531, 2007.

 

74. Corradi A., Zanardi A., Giacomini C., Onofri F., Valtorta F., Zoli M., Benfenati F.

Synapsin I and synapsin II null mice display an increased age-dependent cognitive impairment

J. Cell Sci., 121: 3042-3051, 2008.

 

75. Bonanomi D., Fornasiero E.F., Valdez G., Halegoua S., Benfenati F., Menegon A., Valtorta F.

Identification of a developmentally-regulated pathway of membrane retrieval in neuronal growth cones

J. Cell Sci., 121: 3757-3769, 2008.

 

76. Chiappalone M., Casagrande S. Tedesco M., Valtorta F., Baldelli P., Martinoia S., Benfenati F.

Opposite changes in glutamatergic and GABAergic transmission underlie the diffuse hyperexcitability of Synapsin I-deficient cortical networks.

Cerebral Cortex, Epub ahead of print10.1093/cercor/bhn182, 2008.

 

77. Bianchi V., Farisello P., Baldelli P., Meskenaite V., Vecellio M., Mühlemann S., Lipp H.P., Bonanno G., Benfenati F., Toniolo D., D’Adamo P.

Cognitive impairment in Gdi1 deficient mice is associated with altered synaptic vesicle pools and short-term synaptic plasticity, and can be corrected by appropriate learning training.

Hum. Mol. Genetics, 18: 105-117, 2009.

 

78. A. Blau, T. Neumann, C. Ziegler, F. Benfenati

Replica-molded polydimethylsiloxane culture vessel lids attenuate osmotic drift in long-term cell culturing

J. Biosciences, 2009, 34: 59-69, 2009.

 

79. Messa M., C. Canale, E. Marconi, R. Cingolani, M. Salerno, F. Benfenati

Growth cone three-dimensional morphology is modified by distinct micropatterned adhesion substrates.

IEEE Trans Nanobiosci., Epub ahead of print Apr 10, 2009.

 

80. Vara H., Onofri F., Benfenati F., Sassoè-Pognetto M., and Giustetto M.

ERK activation in presynaptic varicosities modulates post-tetanic potentiation in the CA3 region of the hippocampus through synapsin I.

Proc. Natl. Acad. Sci. USA, 2009, in press.

SELECTED PUBLICATIONS IN REFEREED JOURNALS

1. Pang D.T., Wang J.K., Valtorta F., Benfenati F., Greengard P. Protein tyrosine phosphorylation in synaptic vesicles. Proc. Natl. Acad. Sci. USA 85: 762‑766, 1987.

2. Bähler M., Benfenati F., Valtorta F., Czernik A.J., Greengard P.

Characterization of synapsin I fragments by cysteine-specific cleavage: a study of their interactions with F-actin.

J. Cell Biol. 108: 1841-1849, 1989.

3. Benfenati F., Bähler M., Brunner J., Greengard P.

Electrostatic ...

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