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PeopleAlessandro Bosca
Alessandro Bosca's foto

Alessandro Bosca

Post-Doc

NBT / Neurotechnologies


Address Via Valtrebbia 43 / 5
City Genoa
ZIP Code 16141
Country Italy
Phone 390105737470
Mobile Phone 393206638859
Fax 390105737470
IM Address james81bong@ymail.com (Skype)

Bio

Alessandro Bosca graduated with full marks in Physics at the University of Genoa in 2006, studying viscoelasticity and adhesion of polymers on nanostructured surfaces on the micrometric scale by means of Atomic Force Microscopy (AFM). His research had taken place within a national PRIN 2004-2006 centered on “Nanotribology” and benefited of the collaboration of the S3 National Research Center of CNR-INFM in Modena. In his work colloidal AFM probes has been created and an experimental setup and methodology has been developed and implemented by commercial hardware and custom made software. Silicon substrates have been consciously nanostructured, using a modified algorithm for fractal surfaces generation, with a Focused Ion Beam (FIB). The precision of the milling process has been characterized and optimized.

Currently, he has a Ph.D student position at Italian Institute of Technology (IIT) on the developing and characterization of a new nanostructured device for measuring the electrophysiological activity of biological neuronal networks. In order to perform his tasks he is now concerning with topics just like alternative micro and nano-structuring techniques, biomaterials, biosensors, microfluidics and cell adhesion while deepening his knowledge in laboratory related subjects like cell cultures, electrophysiological techniques, electronics and object oriented programming.

Alessandro Bosca has a good experimental and theoretical background in the use of AFM, especially in force spectroscopy, and experience in the physics and use of polymers and Focused Ion Beam. Thanks to his academic preparation he has fundamental knowledge about the physics of mesoscopic systems and biophysics; also he can use analytical techniques like optical, confocal, two-photon and SEM microscopy.

Projects

 

Development of a Nanostructured Device for Measuring the Electrophysiological Activity of Biological Neural Networks


Tutor

 

Valbusa Ugo

Abstract

The final aim of this project is the development of a planar patch clamp device suited to measure simultaneously the ionic currents flowing in cultured neurons associated in a network. This will permit to study the molecular mechanism underlying information coding and propagation in biological neural systems and therefore investigate the physiological behavior of neuronal networks in their functioning and developing.

Other Publications

R.Buzio , A.Bosca , S.Krol , D.Marchetto , S.Valeri and U.Valbusa
Deformation and Adhesion of Elastomer Polydimethylsiloxane Colloidal AFM Probes.
Langmuir Vol. 23, No. 18 p.9293-9302

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