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People ■ Oscar Sasso
Oscar Sasso's foto

Oscar Sasso

Post Doc

iit / Drug Discovery and Development

Phone +39 010 71781920

Bio

Oscar Sasso graduated in Pharmaceutical Chemestry in 2005 at the University of Naples Federico II with a thesis on the modulation of neurophatic and inflammatory pain by the endocannabinoid trasnsport inhibitor. His PhD program started in laboratories of Experimental Department of Pharmacology in Naples under the supervision of Prof. Calignano and in 2009 he obtained a PhD in pharmacology with a thesis on the role of palmitoylethanolamide in central nervous system, in neurosteroids de novo biosinthesis. Part of the studies was accomplished at the CARD Institute of King’s College of London (Prof. M. Malcangio). In 2010 he joined the Drug Discovery and Development group at the Italian Institute of Technology in Genova, where he was initially involved in new molecular targets of inflammation and pain process. He has received several awards and honors for research.

Oscar Sasso graduated in Pharmaceutical Chemestry in 2005 at the University of Naples Federico II with a thesis on the modulation of neurophatic and inflammatory pain by the endocannabinoid trasnsport inhibitor. His PhD program started in laboratories of Experimental Department of Pharmacology in Naples under the supervision of Prof. Calignano and in 2009 he obtained a PhD in pharmacology with a thesis on the role of palmitoylethanolamide in central nervous system, in neurosteroids de novo ...

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Selected Publications

 

1. Russo R, Lo Verme J, La Rana G, D'Agostino G, Sasso O, Calignano A, Piomelli D. Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647. Eur J Pharmacol. 2007; 566 (1-3): 117-9.

2. D'Agostino G, La Rana G, Russo R, Sasso O, Iacono A, Esposito E, Mattace Raso G, Cuzzocrea S, Lo Verme J, Piomelli D, Meli R, Calignano A. Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous PPAR-{alpha} agonist, modulates carrageenan-induced paw edema in mice. J Pharmacol Exp Ther. 2007; 322 (3): 1137-43.

3. G. La Rana, R. Russo, G. D'Agostino, O. Sasso, G. Mattace Raso, A. Iacono, R. Meli, D. Piomelli and A. Calignano. AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors. Neuropharmacology. 2008; 54 (3): 521-9

4. D'Agostino G, La Rana G, Russo R, Sasso O, Iacono A, Esposito E, Mattace Raso G, Cuzzocrea S, Loverme J, Piomelli D, Meli R, Calignano A. Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia. Eur J Pharmacol. 2009; 613 (1-3): 54-9.

5. Curcio A, Sasso O, Melisi D, Nieddu M, La Rana G, Russo R, Gavini E, Boatto G, Abignente E, Calignano A, Rimoli MG. Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations. J Med Chem. 2009; 52 (12): 3794-800.

6. O Sasso, G La Rana, S Vitiello, R Russo, G D'Agostino, A Iacono, E Russo, R Citraro, S Cuzzocrea, Pier Vincenzo Piazza, G De Sarro, R Meli, A Calignano. Palmitoylethanolamide modulates pentobarbital-evoked hypnotic effect in mice. Involvement of allopregnanolone biosynthesis. Eur Neuropsychopharmacol. 2010; 20 (3): 195-206.

7. Staniland AA, Clark AK, Wodarski R, Sasso O, Maione F, D'Acquisto F, Malcangio M. Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice. J Neurochem. 2010; 114 (4): 1143-57.

8. Clark AK, Wodarski R, Guida F, Sasso O, Malcangio M. Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor. Glia. 2010; 58 (14): 1710-26.

9. Raso GM, Esposito E, Vitiello S, Iacono A, Santoro A, D'Agostino G, Sasso O, Russo R, Piazza PV, Calignano A, Meli R. Palmitoylethanolamide stimulation induces allopregnanolone synthesis in C6 Cells and primary astrocytes: involvement of peroxisome-proliferator activated receptor-α. J Neuroendocrinol. 2011; 23 (7): 591-600.

10. Sasso O, Russo R, Vitiello S, Mattace Raso G, D'Agostino G, Iacono A, La Rana G, Vallée M, Cuzzocrea S, Piazza PV, Meli R, Calignano A. Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain. Pain. 2012; 153 (1): 33-41.

11. Fu j, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M, Guijarro A, Lodola A, Armirotti A, Garau G, Bandiera T, Reggiani A, Mor M, Cavalli A, Piomelli D. A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat Neurosci. 2011; 15 (1): 64-9

12. Sasso O, Bertorelli R, Bandiera T, Scarpelli R, Colombano G, Armirotti A, Moreno-Sanz G, Reggiani A, Piomelli D. Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacol Res. 2012; 65 (5): 553-63.

 

1. Russo R, Lo Verme J, La Rana G, D'Agostino G, Sasso O, Calignano A, Piomelli D. Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647. Eur J Pharmacol. 2007; 566 (1-3): 117-9.

2. D'Agostino G, La Rana G, Russo R, Sasso O, Iacono A, Esposito E, Mattace Raso G, Cuzzocrea S, Lo Verme J, Piomelli D, Meli R, Calignano A. Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous PPAR-{alpha} agonist, modulates ...

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