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People ■ Gian Filippo Ruda
Gian Filippo Ruda's foto

Gian Filippo Ruda

Post Doc

iit / Drug Discovery and Development


Phone +39 010 71781922

Bio

Gian Filippo Ruda graduated in Organic Chemistry at the University of Sassari in 2002. During his thesis project he worked on the synthesis of peptides supported on polyethylene glycol under the supervision of Prof. Maurizio Taddei (University of Siena).

In February 2002 he joined the group of Prof. Ian Gilbert at the Welsh School of Pharmacy in Cardiff (UK) where he worked on the synthesis of inhibitors of the enzyme dUTPase for the treatment of infectious diseases. During his PhD study he spent few months at the Pharmacy Department of the Brighton University under the supervision of Prof. Jean-Yves Maillard. In July 2005 he received his PhD in Medicinal Chemistry.

In August 2005 Dr. Ruda moved with Prof. Gilbert to the Division of Chemical Biology and Drug Discovery of the University of Dundee (UK) where he worked as postdoctoral medicinal chemist collaborating to several projects on the field of neglected diseases in particular Human African Trypanosomiasis, Malaria and Aspergillosis. He also collaborated with Prof. Andrew Hopkins (University of Dundee) to test the proof-of -concept of new computational methods for rationally design of multi-target drugs with polypharmacology.

Gian Filippo Ruda joined the Department of Drug Discovery and Development D3 at the IIT in June 2010 as Senior Postdoc.

 

Gian Filippo Ruda graduated in Organic Chemistry at the University of Sassari in 2002. During his thesis project he worked on the synthesis of peptides supported on polyethylene glycol under the supervision of Prof. Maurizio Taddei (University of Siena).

In February 2002 he joined the group of Prof. Ian Gilbert at the Welsh School of Pharmacy in Cardiff (UK) where he worked on the synthesis of inhibitors of the enzyme dUTPase for the treatment of infectious diseases. During his PhD study he spent few ...

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Selected Publications

  • Besnard J., Ruda G. F., Setola V., Abecassis K., Rodriguiz R. M., Xi-Ping Huang X., Norval S., Sassano M. F., Shin A. I.,. Webster, L. A., Simeons F. R. C., Stojanovski L., Prat A., Seidah N. G., Constam D. B., Bickerton G. R., Read K. D., Wetsel W. C., Gilbert I. H., Roth B. L., Hopkins A. L. Automated design of ligands to polypharmacological profiles. Nature 2012, 492, 215–22. doi:10.1038/nature11691
  • RecioE., Musso-Buendía A., Vidal A. E., Ruda G. F., Kasinathan G., Nguyen C., Ruiz-Pérez L. M., Gilbert I H., González-Pacanowska D. Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase. Eur. J. Med. Chem. 2011, 46, 8, 3309-3314.
  • Ruda G. F., Nguyen C., Ziemkowski P., Felczak K., Kasinathan G., Musso-Buendia A., Sund C.,  Zhou X., Kaiser M., Ruiz-Pérez L. M., Brun R.,  Kulikowski T., Johansson N. G., González-Pacanowska D., Gilbert I. H. Modified 5’-Trityl-nucleosides as Inhibitors of Plasmodium falciparum dUTPase, Chem. Med. Chem2011, 6, 2, 309-320.
  • Cui H., Ruda G. F., Carrero-Lérida J., Ruiz-Pérez L., Gilbert I. H., González-Pacanowska D., Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase,  Eur. J. Med. Chem. 2010, 45, 11, 5140-49, doi: 10.1016/j.ejmech.2010.08.026.
  • Ruda, G. F.; et al., Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent trypanocidal Compounds. J. Med. Chem. 2010, doi: 10.1021/jm1004754.
  • Ruda G.F., Campbell G., Alibu V.P., Barrett M.P, Brenk R., Gilbert I. H., Virtual Fragment Screening for Novel Inhibitors of 6-Phosphogluconate Dehydrogenase. Bioorg. Med. Chem. 2010, 18, 5056-62.
  • Ruda, G. F.; Alibu, V. P.; Mitsos, C.; Bidet O.; Kaiser, M.; Brun, R.; Barrett, M. P.; Gilbert, I. H.Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-d -erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase, Chem. Med. Chem. 2007, 2, 1169-1180.
  • Sundaramoorthy, R.; Iulek, J.; Barrett, M. P.; Bidet, O.; Ruda, G. F.; Gilbert, I. H.; Hunter, W. N. ‘Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates’ Febs J. 2007, 274, 275-286.
  • Nguyen, C.; Ruda, G. F.; Schipani, A.; Kasinathan, G.; Leal, I.; Musso-Buendia, A.; Kaiser, M.; Brun, R.; Ruiz-Perez, L. M.; Sahlberg, B. L.; Johansson, N. G.; Gonzalez-Pacanowska, D.; Gilbert, I. H. ‘Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase’. J. Med. Chem. 2006, 49, 4183-4195.
  • Gilbert, Ian; Nguyen, Corinne; Ruda, Gian Filippo; Schipani, Alessandro; Kasinathan, Ganasan; Johansson, Nils-Gunnar; Pacanowska, Dolores Gonzales.  Preparation of deoxyuridine nucleosides as dUTPase inhibitors.    PCT Int. 2005, 73 pp.  WO  2005066160
  • Gilbert, I. H.; Nguyen, C.; Ruda, G. F.; Schipani, A.; Kasinathan, G.; Johansson, N.; Pacanowska, D. G. Preparation of pyrimidinediones as deoxyuridine triphosphate nucleotidohydrolase (dUTPase) inhibitors for treatment of parasitic infections . PCT Int. 2005, WO2005065689A1
  • Porcheddu, A.; Ruda, G. F.; Sega, A.; Taddei, M. ‘A new, rapid, general procedure for the synthesis of organic molecules supported on methoxy-polyethylene glycol (MeOPEG) under microwave irradiation conditions’ Eur. J. Org. Chem. 2003, 907-912.
  • Besnard J., Ruda G. F., Setola V., Abecassis K., Rodriguiz R. M., Xi-Ping Huang X., Norval S., Sassano M. F., Shin A. I.,. Webster, L. A., Simeons F. R. C., Stojanovski L., Prat A., Seidah N. G., Constam D. B., Bickerton G. R., Read K. D., Wetsel W. C., Gilbert I. H., Roth B. L., Hopkins A. L. Automated design of ligands to polypharmacological profiles. Nature 2012, 492, 215–22. doi:10.1038/nature11691
  • RecioE., Musso-Buendía A., Vidal A. E., Ruda G. F., Kasinathan G., Nguyen C., Ruiz-Pérez ...

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