Director Alberto Diaspro
Alberto Diaspro is Director of the Department of Nanophysics at the Istituto Italiano di Tecnologia (IIT), Professor of Applied Physics at the Department of Physics of University of Genova, and scientific coordinator of the Ph.D. Course in Nanosciences at the University of Genova within an IIT program. He is President of OWLS (Optics with Life Sciences), past President of EBSA (European Biophysical Societies Association), Appointed Vice President of ICO (Interational Commission of Optics) and founder of the Nanoscale Biophysics Subgroup of the Biophysical Society.
During the 90’s he carried out part of his research activity at Drexel University (PA, USA), Universidad Autonoma de Madrid (Spain) and Czech Academy of Sciences (Czech Republic). He also coordinates a research program (2004-2012) at IFOM-IEO Campus in Milano on Biomedical Research and is associated with the Institute of Biophysics of the National Research Council (CNR) since 2006. He founded LAMBS (Laboratory for Advanced Microscopy, Bioimaging and Spectroscopy) in 2003. He realized a hybrid artificial “nanobiorobot” within EU and national Research Projects (2000-2005), and designed and realized the first Italian multiphoton microscope within a research grant of the National Institute of Physics of Matter (1999). He recently directed the design and realization of the first Italian nanoscopy architecture at the Neuroscience and Brain Technologies Department of IIT (2008).
At present, Alberto Diaspro coordinates two IIT applied research programs with Leica Microsystems and Nikon Instruments on multiphoton nanoscopy and super resolution microscopy of large 3D biological objects, respectively.
He is coordinator of several EU and national research programs, and published more than 230 international peer reviewed papers. He is active member of international editorial boards and societies (e.g. senior IEEE member).
His specific research experience is related to the design, realization and utilization of optical and biophysical instrumentation as far-field super resolution optical microscopy and nanoscopy, conventional and confocal microscopy, two-photon fluorescence microscopy and spectroscopy architecture, differential scanning calorimetry, scanning probe microscopy (STM, SNOM, AFM), polarized light scattering, signal and image digital processing. His main interests are molecular oncology (chromatin, endocytosis and adhesion mechanisms), neuroscience (brain mapping and neuronal network signaling) and smart materials (intelligent drug delivery and nanocomposite materials).
Diaspro’s selected publications
- F. Cella Zanacchi, Z. Lavagnino, M. Perrone Donnorso, A. Del Bue, L. Furia, M. Faretta, A. Diaspro, “Live-cell 3D super-resolution imaging in thick biological samples”, Nature Methods, in press (2011) DOI 10.1038/nmeth.1744.
- A. Palamidessi, E. Frittoli, M. Garré, M. Faretta, M. Mione, I. Testa, A. Diaspro, L. Lanzetti, G. Scita, P. P. D. Fiore, “Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration”, Cell, 134(1), 135-147 (2008) DOI 10.1016/j.cell.2008.05.034.
- S. Krol, S. del Guerra, M. Grupillo, A. Diaspro, A. Gliozzi, P. Marchetti, “Multilayer nanoencapsulation. New approach for immune protection of human pancreatic islets”, Nano Lett. 6(9), 1933–9 (2006) DOI 10.1021/nl061049r.
- A. Diaspro, G. Chirico, M. Collini, “Two-photon fluorescence excitation and related techniques in biological microscopy”, Q. Rev. Biophys 38(2), 97-166 (2005) DOI:10.1017/S0033583505004129.
- A. Diaspro, D. Silvano, S. Krol, O. Cavalleri, A. Gliozzi, “Single Living Cell Encapsulation in Nano-organized Polyelectrolyte Shells”, Langmuir 18(13), 5047-5050 (2002) DOI: 10.1021/la025646e.
He edited three international key books in the microscopy area: “Nanoscopy and Multidimensional Optical Fluorescence Microscopy”, Taylor &Francis Group, A Chapman & Hall Book Crc Press (2010), pp.448; “Optical Fluorescence Microscopy: from the spectral to the nano dimension”, Springer-Verlag, Berlin and Heidelberg GmbH & Co. K., (2010), pp. 256; “Confocal and Two-Photon Microscopy: Foundations, Applications and Advances”, Wiley-Liss (2001), pp. 580.