Velia Siciliano received her Bachelor degree in Health Biotechnology and her Master Degree in Medical Biotechnology from the University of Naples Federico II.
In 2012 she obtained the PhD in Human Genetics from Open University UK in a joint program with the Telethon Institute of Genetics and Medicine Naples (TIGEM), and she then moved to Massachusetts Institute of Technology where she worked as postdoctoral fellow at the Synthetic Biology Center of MIT.
She was awarded with the Junior Research Fellowship from Imperial College London in 2015 to conduct her independent research in the Department of Medicine. In 2017 she won the Proof of Concept grant from SynbiCITE London and she is part of a H2020 consortium grant led by Prof. diBernardo (TIGEM, Naples).
Velia joined IIT in September 2017 where she leads the System and Synthetic Biology lab for biomedicine. She is also Honorary Research Fellow at the Department of Medicine of Imperial College London.
Velia is a reviewer for a number of scientific journals, including Nature Communication, Nucleic Acid Research, BMC Systems Biology, etc.
Development of Systems and Synthetic Biology approaches for unravelling mechanisms underlying biological pathways and diseases.
Study of microRNA contribution to T-Cell exhaustion.
Design of genetically encoded sensor-actuator devices to counteract the T-Cell exhaustion emergency and to define critical parameters that lead to dysfunction in immunotherapies.
Study of impact of exogenous genetic loads on cellular burden.
1. MacDonald J.T., Siciliano V. Promoter design – selecting transcriptionally silent regions. Methods in Molecular Biology, 2017.
2. Wroblewska L, Endo K, Kitada T, Siciliano V, Saito H, Weiss R. Engineering mammalian cells with RNA-encoded synthetic translational circuits. Nat Biotechnol. 2015 Aug;33(8):839-41. doi: 10.1038/nbt.3301.
3. Stanton B, Siciliano V, Ghodasara A, Wroblewska L, Clancy K, Trefzer A, Chesnut J, Weiss R, Voigt C. Systematic transfer of prokaryotic sensors and circuits to mammalian cells. ACS Synth Biol. 2014 Dec 19;3(12):880-91. doi: 10.1021/sb5002856.
4. Siciliano V, Garzilli I, Fracassi C, Ventre S, Criscuolo S, di Bernardo D. miRNAs confer phenotypic robustness to gene networks by suppressing biological noise: a synthetic biology approach. Nat Commun. 2013;4:2364. doi: 10.1038/ncomms3364.
5. Menolascina F*, Siciliano V*, di Bernardo D. Engineering and Control of Biological Systems: A New Way to Tackle Complex Diseases and Biotechnological Innovation. FEBS Lett. 2012 Jul 16;586(15):2122-8. doi: 10.1016/j.febslet.2012.04.050.
6. di Bernardo D, Marucci L, Menolascina F, Siciliano V. Predicting synthetic gene networks. Methods Mol Biol. 2012;813:57-81. doi: 10.1007/978-1-61779-412-4_4.
7. Siciliano V., Menolascina F., Marucci L., Fracassi C., Garzilli I., Moretti M.N., diBernardo D. Construction and modelling of an inducible positive feedback loop stably integrated in a mammalian cell-line. PLoS Comput Biol. 2011 Jun;7(6):e1002074. doi: 10.1371/journal.pcbi.1002074
8. BelcastroV., Siciliano V., Gregoretti F., Pratibha M., Iorio F., Santoro M., D’Angelo G., Oliva G., Brunetti-Pierri N., diBernardo D., Transcriptional gene network inference from a massive dataset elucidates transcriptome organization and gene function. Nucleic Acids Res. 2011 Nov 1;39(20):8677-88. doi: 10.1093/nar/gkr593
9. BelcastroV., Gregoretti F., Siciliano V., Santoro M., D’Angelo G., diBernardo D. Reverse engineering and analysis of genome-wide gene regulatory networks from gene expression profiles using high-performance computing. IEEE/ACM Trans Comput Biol Bioinform. 2012 May-Jun;9(3):668-78. doi: 10.1109/TCBB.2011.60.
10. Cuccato, G.,Polynikis,A., Siciliano, V., Graziano, M., di Bernardo, M., diBernardo, D., Modeling RNA interference in mammalian cells. BMC Syst Biol. 2011 Jan 27;5:19. doi: 10.1186/1752-0509-5-19.
2015 Junior Research Fellowship, Imperial College London
2014 Honorable Mention Prize for cutting-edge research, Synberc
2006 Award from Universita’ degli studi di Napoli Federico II
2004 Award from Universita’ degli studi di Napoli Federico II