- 27 July 2004 -Degree in Biological Sciences achieved at the University of Genoa, with experimental thesis at the Department of Oncology, Biology and Genetics entitled: “Molecular effects of a combined radio-chemical therapy on experimental tumors”.
During her thesis she studied two different types of murine cancers: a line of murine embryonal teratocarcinoma called F9, and a line of transgenic breast cancer called MG 1361 (obtained by MMTV-neu transgenic mice). During her degree training she was involved in “in vitro” and “in vivo” studies focused on characterization of molecular effects of different kinds of treatment on molecular markers, i.e. p53, involved in apoptosis and necrosis of cancer cells.
- October 2004/February 2009 - Fellow at the “Laboratory of Immunoterapy” and at the “Laboratory of Therapeutic Recombinant Proteins”, directed by Prof. Luciano Zardi, at the Advanced Technology Centre of Genoa.
During these years she was involved in the production and characterization of recombinant proteins. Her studies were focused on the characterization of new proteins using molecular techniques as SDS-PAGE and FPLC (Fast Protein Liquid Chromatography). She was involved in experiments regarding the “in vivo” effects of these products on different types of tumors (the line F9 grown in 129J mice, and a line of human melanoma cancer called SKMel grown in Nude mice) and she also provided the support for biodistribution experiments.
- March 2009/present - Fellow at the "Department of Neuroscience and Brain Technologies" directed by Prof. Fabio Benfenati, at the Fondazione Istituto Italiano di Tecnologia of Genoa.
- 19 April 2013 - PhD on Life and Humanoid Technologies, Course in Neuroscience and Brain Technologies,at the Fondazione Istituto Italiano di Tecnologia, Department of Neuroscience and Brain Technologies, with experimental thesis entitled: “Characterization of the Octopus arm morphology and its regenerative capability”.
From March 2009 to now I am involved in a project whose purpose is the study of Octopus vulgaris arm regeneration. In particular I studied the expression of specific markers involved in cellular proliferation (AgNOR and PCNA) and the role of Acetylcholinesterase during the regenerative process. Using degenerate PCR I cloned Octopus AChE, characterized the sequence by phylogenetic analysis and molecular modeling and I performed an analysis of the Octopus AChE expression during the process of arm regeneration.
Astigiano S, Damonte P, Fossati S, Boni L, Barbieri O. (2005). Fate of embryonal carcinoma cells injected into postimplantation mouse embryos. Differentiation, 73(9-10):484-490.
Mortara L, Balza E, Sassi F, Castellani P, Carnemolla B, De Lerma Barbaro A, Fossati S, Tosi G, Accolla RS and Borsi L. (2007). Therapy-induced antitumor vaccination by targeting tumor necrosis factor-a to tumor vessels in combination with melphalan. Eur. J. Immunology, 37:1-12.
Ventura E, Sassi F, Fossati S, Parodi A, Blalock W, Balza E, Castellani P, Borsi L, Carnemolla B, Zardi L. (2009). Use of uteroglobin for the engineering of polyvalent, polyspecific fusion proteins. J. Biol. Chem., 284(39):26646-26654.
Balza E, Sassi F, Ventura E, Parodi A, Fossati S, Blalock W, Carnemolla B, Castellani P, Zardi L, Borsi L. (2009). A novel human fibronectin cryptic sequence unmasked by the insertion of the angiogenesis-associated extra type III domain B. Int. J. Cancer, 125(4):751-758.
Zullo L, Fossati SM, Hochner B and Benfenati F. (2009). Physiological characterization of octopus arm and sucker. J Mol Neurosci, 39 (Suppl 1):S131-132.
Fossati SM, Benfenati F, Hochner B and Zullo L. (2009). Morphological characterization of the octopus arm relevant to robotics. J Mol Neurosci, 39 (Suppl 1):S131-S132.
Fossati SM, Benfenati F, Zullo L. (2011). Morphological characterization of the Octopus arm. Vie et Milieu/Life & Environment, 61(4): 191-195.
Zullo L, Fossati SM, Benfenati F. (2011). Transmission of sensory responses in the peripheral nervous system of the arm of Octopus vulgaris. Vie et Milieu/Life & Environment, 61(4): 197-201.
Fossati SM, Carella F, De Vico G, Benfenati F, Zullo L. (2012). Octopus arm regeneration: role of Acetylcholinesterase during morphological modification. JEMBE, 447:93-99.
Fossati SM, Candiani S, Nödl MT, Maragliano L, Pennuto M, Domingues P, Benfenati F, Pestarino M, Zullo L. (2014). Identification and Expression of Acetylcholinesterase in Octopus vulgaris Arm Development and Regeneration: a Conserved Role for ACHE? Molecular Neurobiology, doi: 10.1007/s12035-014-8842-2.