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Sara Maria Fossati

Post Doc

Former colleague

Center

NSYN@Unige Genova

Contacts

Via Morego 30

About

27 July 2004 -Degree in Biological Sciences achieved at the University of Genoa, with experimental thesis at the Department of Oncology, Biology and Genetics entitled: “Molecular effects of a combined radio-chemical therapy on experimental tumors”.
During her thesis she studied two different types of murine cancers: a line of murine embryonal teratocarcinoma called F9, and a line of transgenic breast cancer called MG 1361 (obtained by MMTV-neu transgenic mice). During her degree training she was involved in “in vitro” and “in vivo” studies focused on characterization of molecular effects of different kinds of treatment on molecular markers, i.e. p53, involved in apoptosis and necrosis of cancer cells.

October 2004/February 2009 - Fellow at the “Laboratory of Immunoterapy” and at the “Laboratory of Therapeutic Recombinant Proteins”, directed by Prof. Luciano Zardi, at the Advanced Technology Centre of Genoa.
During these years she was involved in the production and characterization of recombinant proteins. Her studies were focused on the characterization of new proteins using molecular techniques as SDS-PAGE and FPLC (Fast Protein Liquid Chromatography). She was involved in experiments regarding the “in vivo” effects of these products on different types of tumors (the line F9 grown in 129J mice, and a line of human melanoma cancer called SKMel grown in Nude mice) and she also provided the support for biodistribution experiments.

- March 2009/present - Fellow at the "Department of Neuroscience and Brain Technologies" directed by Prof. Fabio Benfenati, at the Fondazione Istituto Italiano di Tecnologia of Genoa.
19 April 2013 - PhD on Life and Humanoid Technologies, Course in Neuroscience and Brain Technologies,at the Fondazione Istituto Italiano di Tecnologia, Department of Neuroscience and Brain Technologies, with experimental thesis entitled: “Characterization of the Octopus arm morphology and its regenerative capability”.
From March 2009 to now I am involved in a project whose purpose is the study of Octopus vulgaris arm regeneration. In particular I studied the expression of specific markers involved in cellular proliferation (AgNOR and PCNA) and the role of Acetylcholinesterase during the regenerative process. Using degenerate PCR I cloned Octopus AChE, characterized the sequence by phylogenetic analysis and molecular modeling and I performed an analysis of the Octopus AChE expression during the process of arm regeneration. 










Selected Publications

Astigiano S, Damonte P, Fossati S, Boni L, Barbieri O. (2005). Fate of embryonal carcinoma cells injected into postimplantation mouse embryos. Differentiation, 73(9-10):484-490.

Mortara L, Balza E, Sassi F, Castellani P, Carnemolla B, De Lerma Barbaro A, Fossati S, Tosi G, Accolla RS and Borsi L. (2007). Therapy-induced antitumor vaccination by targeting tumor necrosis factor-a to tumor vessels in combination with melphalan. Eur. J. Immunology, 37:1-12.

Ventura E, Sassi F, Fossati S, Parodi A, Blalock W, Balza E, Castellani P, Borsi L, Carnemolla B, Zardi L. (2009). Use of uteroglobin for the engineering of polyvalent, polyspecific fusion proteins. J. Biol. Chem., 284(39):26646-26654.

Balza E, Sassi F, Ventura E, Parodi A, Fossati S, Blalock W, Carnemolla B, Castellani P, Zardi L, Borsi L. (2009). A novel human fibronectin cryptic sequence unmasked by the insertion of the angiogenesis-associated extra type III domain B. Int. J. Cancer, 125(4):751-758.

Zullo L, Fossati SM, Hochner B and Benfenati F. (2009). Physiological characterization of octopus arm and sucker. J Mol Neurosci, 39 (Suppl 1):S131-132.

Fossati SM, Benfenati F, Hochner B and Zullo L. (2009). Morphological characterization of the octopus arm relevant to robotics. J Mol Neurosci, 39 (Suppl 1):S131-S132.

Fossati SM, Benfenati F, Zullo L. (2011). Morphological characterization of the Octopus arm. Vie et Milieu/Life & Environment, 61(4): 191-195.

Zullo L, Fossati SM, Benfenati F. (2011). Transmission of sensory responses in the peripheral nervous system of the arm of Octopus vulgaris. Vie et Milieu/Life & Environment, 61(4): 197-201.

Fossati SM, Carella F, De Vico G, Benfenati F, Zullo L. (2012). Octopus arm regeneration: role of Acetylcholinesterase during morphological modification. JEMBE, 447:93-99.

Fossati SM, Candiani S, Nödl MT, Maragliano L, Pennuto M, Domingues P, Benfenati F, Pestarino M, Zullo L. (2014). Identification and Expression of Acetylcholinesterase in Octopus vulgaris Arm Development and Regeneration: a Conserved Role for ACHE? Molecular Neurobiology, doi: 10.1007/s12035-014-8842-2.

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.