Olga Barca was born in 1978, in Santiago, Spain. She is a senior Post Doc at the Neurobiology of mIRNAS and IIT-NetS3 laboratories at the Dpt. of Neuroscience and Brain Technologies (Fondazione Istituto Italiano di Tecnologia (IIT, Genova, Italy)).
She pursued a PhD in Neuroendocrionology at the Department of Physiology at the University of Santiago de Compostela (Spain) and graduated Cum Laude (2008). After obtaining her PhD degree, she moved as post-doc to the Laboratory of Dr Roy Weiss and Dr Samuel Refetoff, at the Department of Medicine of the University of Chicago where she focused on endocrinology and metabolism in physiological and pathological conditions. The long-term interest in neuroscience and neurophysiology prompted her to pursue a second Post-doc experience and in (2011) she moved to the laboratory of Dr. Richard Lu at the Developmental Department in UTSW (Dallas, Texas) to investigate glia development and physiology.
In 2013, she moved to IIT (Genova) as senior postdoc and was awarded with two Marie Curie Fellowships (CIG and IEF) to explore the explore the contribution of astrocyte circadian rhythms ("astroclock") to the timekeeping system. Two years later, in 2015, she was awarded with a Cariplo Research Grant to explore the role of "astroclock" in diseases associated to alteration of circadian rhythms, such as metabolic and age associated neuropathology.
2016-2019 - Cariplo Research Grant. Role of the astrocyte-mediated circadian clock in neurodegeneration and brain aging.
2014-2016 - Marie Curie Intra-European fellowship ASTROCLOK (grant agreement PIEF-GA-2013-629867): Astrocyte regulation of circadian behavior.
The human brain contains more than 100 billion cells, the majority being non-excitable glial cells, remarkably coordinated by an intrinsic clock that produce a circadian rhythm in their physiology and behavior. Circadian alterations affect human performances, productivity and are associated to increased risk of human-error related accidents and to a variety of brain disorders (e.g. sleep disorders). However, neuropharmacological R&D faces the lack of knowledge on how this clock signaling is hierarchically orchestrated within so many brain cells to lead to the cycle-to-cycle precision of circadian rhythmicity.
Recent studies suggest that astrocytes (the most abundant cells of the brain) actively participate in the modulation of physiological and circadian behavioral processes in invertebrates. Although astrocytes are directly involved in the regulation of synaptic neuronal signaling (“tripartite synapse”), the role of astrocytes in controlling circadian behavior in mammals is largely unknown.
This projects converges an original multidisciplinary research program, spanning the fields of molecular neurobiology, neuroelectronics and circadian biology, to unravel the molecular and functional mechanisms by which neurons and astrocytes cooperate to influence circadian rhythmicity in mammals. To do so, innovative genetics, molecular profiling (deep sequencing), behavioral, imaging and electrophysiological approaches will be used. The results of this proposal will lead to a deeper understanding on circadian rhythms in the brain and to the potential identification of new cellular and signaling targets for neuropharmacology.
1.- O. Barca, S. Ferré, M. Seoane, JM. Prieto, M. Lema, RM. Señarís, VM. Arce. Interferon beta promotes survival in primary cultures of rat astrocytes trough PI-3K. J of Neuroimmunol. 2003, 139: 155-9.
2.- Barca O, Seoane M, Ferré S, Prieto JM, Lema M, Señarís R, Arce VM. Mechanisms of interferon-beta-induced survival in fetal and neonatal primary astrocytes. Neuroimmunomodulation. 2007, 14: 39-45.
3.- Barca O, Costoya JA, Señarís RM, Arce VM. Interferon beta protects astrocytes against tumour necrosis factor alpha-induced apoptosis via activation of p38-mitogen activated protein kinase. Exp Cell Res. 2008, 314: 2231-7.
4.- Palos-Paz F, Perez-Guerra O, Cameselle-Teijeiro J, Rueda-Chimeno C, Barreiro-Morandeira F, Lado-Abeal J; Galician Group for the Study of Toxic Multinodular Goitre, Araujo Vilar D, Argueso R, Barca O, Botana M, Cabezas-Agrícola JM, Catalina P, Dominguez Gerpe L, Fernandez T, Mato A, Nuño A, Penin M, Victoria B. Prevalence of mutations in TSHR, GNAS, PRKAR1A and RAS genes in a large series of toxic thyroid adenomas from Galicia, an iodine-deficient area in NW Spain. Eur J Endocrinol. 2008, 159: 623-31.
5.- Olga Barca, Carmen Carneiro, José A. Costoya, Rosa Mª Señarís, Víctor M. Arce. Resistance of neonatal rat primary astrocytes against Fas-induced apoptosis depends on epigenetic silencing of caspase 8. Neurosci Lett. 2010, 479: 206-10.
6. Olga Barca, Pablo Devesa, Rosa Mª Señarís, Víctor M. Arce. Bimodal effect of interferon-β on astrocyte proliferation and survival: Importance of nuclear factor-kB. J Neuroimmunol. 2010, 226: 73-80.
7.- Lado Abeal J, Albero Gamboa R, Araujo Vilar D, Barca Mallo O, Bernabeú Moron I, Calvo MT, Castro Piedras I, Martin Calamata J, Palos Paz F, Peinó R, Peteiro D, Victoria B. Clinical and molecular study of five families with resistance to thyroid hormones. Med Clin (Barc). 2011 Nov 12;137(12):551-4. Research Article.
8. Olga Barca-Mayo, Xiao-Hui Liao, Manuela Alonso, Caterina Di Cosmo, Arturo Mynandez, Samuel Refetoff, Roy E. Weiss. Thyroid hormone receptor alpha and regulation of type 3 deiodinase. Mol Endo. 2011, 25: 575-583. Recommended F1000.
9. Barca-Mayo O, Liao XH, DiCosmo C, Dumitrescu A, Moreno-Vinasco L, Wade MS, Sammani S, Mirzapoiazova T, Garcia JG, Refetoff S, Weiss RE. Role of type 2 deiodinase in response to acute lung injury (ALI) in mice. Proc Natl Acad Sci U S A. 2011, 108: E1321-9.
10. Olga Barca Mayo; Xiao Hui Liao; Caterina DiCosmo; Liliana Moreno Vinasco; Michael S Wade; Saad
11.- Grasberger H, De Deken X, Mayo OB, Raad H, Weiss M, Liao XH, Refetoff S. Mice deficient in dual oxidase maturation factors are severely hypothyroid. Mol Endocrinol. 2012, 26:481-92.
12.- Barca-Mayo O, Lu QR. Fine-Tuning Oligodendrocyte Development by microRNAs. Front Neurosci. 2012;6: 13.
13.- Barca O, Seoane M, Señarís RM, Arce VM. Fas/CD95 Ligation Induces Proliferation of Primary Fetal Astrocytes Through a Mechanism Involving Caspase 8-Mediated ERK Activation. Cell Physiol Biochem. 2013 Jul 12; 32 (1): 111-120.
14.- Barca-Mayo O and De Pietri D. Convergent and divergent miRNA actions control neocortical development. Cellular and Molecular Life Sciences. 02/2014; DOI:10.1007/s00018-014-1576-5.
15.- Marta Liliana Trujillo and Olga Barca Mayo. Protein analysis. Laboratory techniques for research. Editorial Académica Española, 08/2016. ISBN 978-3-639-66598-7. Book chapter. 2016.
16.- Olga Barca-Mayo, Meritxell Pons-Espinal, Philipp Follert, Andrea Armirotti, Luca Berdondini and Davide De Pietri Tonelli. Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signaling. Nat Comm. 2017: 8:14336. doi:10.1038/ncomms14336.
Predoctoral Fellowship. Department of Physiology. School of Medicine. University of Santiago de Compostela. Xunta de Galicia
Award, Technology and Innovative Ideas.University of Santiago de Compostela.
Research Fellowship. Department of Physiology. School of Medicine. University of Santiago de Compostela. Diputación de A Coruña. Resignation in July 2003.
|2003-2006||Predoctoral Fellowship. Department of Physiology. School of Medicine. University of Santiago de Compostela. Xunta de Galicia.|
Grant CTSA-ITM Genomics Core at the University of Chicago
Tess travel grant. ENDO abstract award. The endocrine society.
CIG Marie Curie Fellowship. Resignation in December 2013
IEF Marie Curie Fellowship.
|2015||Award, Gordon Conference, Chronobiology|
|2015||Award, Japan Neuroscience Society|
|2015||Award, EMBO/EMBL, Biological Oscillators: Design, Mechanism, Function|
|2016-2019||Cariplo research grant|
|2016||Award, 21st Biennial Meeting of the International Society for Developmental Neuroscience (ISDN)|