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Giovanni Signore Write a Message

Post Doc

Center

CNI@NEST Pisa

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Piazza san Silvestro,12

About

Education:
2007: PhD in Chemical Sciences University of Pisa, Pisa – Italy
2003: M.Sc. in Industrial Chemistry (Italian Laurea Degree) (110/110 cum laude) University of Pisa, Pisa - Italy

Research interests:

•Synthesis of photocleavable molecules for delivery in living cells.

•Design and enigineering of fluorescent probes (organic dyes or fluorescent proteins) for in vivo studies with single event/single molecule resolution.
•Detection of binding events using fluorescent solvatochromic biosensors.

Research Activity:

• 1st October 2009 to present: IIT Post-Doctoral Fellow at IIT@NEST- Center for Nanotechnology Innovation, Nanomedicine division. Project: development of fluorescent biosensors based on solvatochromic probes for in vivo imaging.

• 1st September 2008- 31th August 2009: Post-doctoral Fellow at NEST-CNR-INFM-Scuola Normale Superiore. Project title: "Intracellular probes of proteins in native state based on fluorescent solvatochromic dyes".
• 1st July 2007-2nd June 2008: Post-Doctoral Fellow at Scuola Normale Superiore. Project title: "Synthesis and characterization of new fluorescent biomarkers".
• 9th September 2006-16th March 2007: internship in the Process Research Laboratory at Boehringer Ingelheim Pharma, Biberach a.d. Riss, DE. Total synthesis of process impurities, development of synthetic sequences directed towards industrial scale-up.

Selected Publications

 

  1. Lorenzo Albertazzi; Marco Brondi; Giovanni Pavan; Sebatian Sulis Sato; Giovanni Signore; Barbara Storti; Gian michele Ratto; Fabio Beltram "Dendrimer-based Fluorescent Indicators: In Vitro and In Vivo Applications" PLoS ONE 2011 accepted
  2. Valerio Voliani, Fernanda Ricci, Giovanni Signore, Riccardo Nifosì, Stefano Luin, Fabio Beltram, "Multiphoton Molecular Photorelease in Click-Chemistry-Functionalized Gold Nanoparticles" Small 2011 doi:10.1002/smll.201101753
  3. Gerardo Abbandonato, Giovanni Signore, Riccardo Nifosì, Valerio Voliani, Ranieri Bizzarri and Fabio Beltram, "Cis–trans photoisomerization properties of GFP chromophore analogs" Eur. Biophys. J. 2011, 40, 1205-1214

  4. Signore Giovanni, Nifosì Riccardo, Albertazzi Lorenzo, Storti Barbara, Bizzarri Ranieri, “Polarity-sensitive coumarins tailored to live cell imaging” Journal of the American Chemical Society 2010, 132, 1276-1288.
  5. Signore Giovanni, Nifosì Riccardo, Albertazzi Lorenzo, Bizzarri Ranieri, “A novel coumarin fluorescent sensor to probe polarity around biomolecules” Journal of Biomedical Nanotechnology 2009, 5, 722-729
  6. Signore Giovanni, Malanga Corrado, Menicagli Rita, “Pyridine and Triphenylphosphine Oxide Activation of Sulfonyl Chlorides in the Syntheses of (E) Alk-1-enyl Sulfones” Tetrahedron, 2008, 64, 11218-11223
  7. Signore Giovanni, Malanga Corrado, Menicagli Rita, “Alkyl alk-1-enyl alanes in Reissert like reaction” Tetrahedron, 2008, 64, 197-203
  8. Signore Giovanni, Calderisi Marco, Malanga, Corrado, Menicagli Rita, “Alkenylalane-pyridine complexes in a new synthesis of aryl alk-1-enyl sulfoxides” Tetrahedron, 2007, 63, 177-182
  9. Signore Giovanni, Samaritani Simona, Malanga Corrado, Menicagli Rita, “Reinheckel Protocol Revisited: Synthesis of (E)-a,b -unsaturated Sulfoxides” Synthesis 2006, 762-764
  10. Dianzani Chiara, Collino Massimo, Gallicchio Margherita, Samaritani Simona, Signore Giovanni, Menicagli Rita, Fantozzi Roberto “Evaluation of in-vitro anti-inflammatory activity of some 2-alkyl-4,6-dimethoxy-1,3,5- triazines” Journal of Pharmacy and Pharmacology 2006, 58, 219-226
  11. Samaritani Simona, Signore Giovanni, Malanga Corrado and Menicagli Rita “Organometallic alkylation of 2-chloro-4,6-dimethoxy-1,3,5-triazine: a study” Tetrahedron 2005, 61, 4475-4483
  12. Menicagli Rita, Samaritani Simona, Signore Giovanni, Vaglini Francesca, Dalla Via Lisa “In Vitro Cytotoxic Activities of 2-Alkyl-4,6-diheteroalkyl- 1,3,5-triazines: New Molecules in Anticancer Research” Journal of Medicinal Chemistry 2004, 47, 4649-4652

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.